Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs104894421
rs104894421
0.700 GeneticVariation UNIPROT

dbSNP: rs121434629
rs121434629
A 0.700 GeneticVariation CLINVAR

dbSNP: rs121913250
rs121913250
0.700 GeneticVariation UNIPROT

dbSNP: rs61753793
rs61753793
0.700 GeneticVariation UNIPROT

dbSNP: rs6413463
rs6413463
0.700 GeneticVariation UNIPROT

dbSNP: rs947141826
rs947141826
0.010 GeneticVariation BEFREE Up-regulation of small GTP-binding proteins smg P21A and ras P21S during TPA-induced differentiation of human leukemia cell lines. 8429689

1993

dbSNP: rs1217691063
rs1217691063
0.070 GeneticVariation BEFREE In contrast, associations for A1298C homozygotes (CC; OR = 0.26 with a 95% CI of 0.07--0.81) and C677T homozygotes (TT; OR = 0.49 with a 95% CI of 0.20--1.17) were observed for hyperdiploid leukemias (n = 138). 11274424

2001

dbSNP: rs397507444
rs397507444
0.020 GeneticVariation BEFREE In contrast, associations for A1298C homozygotes (CC; OR = 0.26 with a 95% CI of 0.07--0.81) and C677T homozygotes (TT; OR = 0.49 with a 95% CI of 0.20--1.17) were observed for hyperdiploid leukemias (n = 138). 11274424

2001

dbSNP: rs1051266
rs1051266
0.010 GeneticVariation BEFREE In genomic DNAs prepared from 105 leukemia (n = 54) and non-leukemia (n = 51) specimens, PCR amplifications and direct sequencing of exon 3 identified a high-frequency G to A single nucleotide polymorphism at position 80 that resulted in a change of arginine-27 to histidine-27. 11705857

2001

dbSNP: rs1258094111
rs1258094111
0.010 GeneticVariation BEFREE The allelic frequencies of G/A80 were nearly identical for the non-leukemia (42.2% CGC and 57.8% CAC) and leukemia (40.7% CGC and 59.3% CAC) genomic DNAs. 11705857

2001

dbSNP: rs765669662
rs765669662
0.010 GeneticVariation BEFREE In genomic DNAs prepared from 105 leukemia (n = 54) and non-leukemia (n = 51) specimens, PCR amplifications and direct sequencing of exon 3 identified a high-frequency G to A single nucleotide polymorphism at position 80 that resulted in a change of arginine-27 to histidine-27. 11705857

2001

dbSNP: rs765669662
rs765669662
0.010 GeneticVariation BEFREE The allelic frequencies of G/A80 were nearly identical for the non-leukemia (42.2% CGC and 57.8% CAC) and leukemia (40.7% CGC and 59.3% CAC) genomic DNAs. 11705857

2001

dbSNP: rs775144154
rs775144154
0.010 GeneticVariation BEFREE The allelic frequencies of G/A80 were nearly identical for the non-leukemia (42.2% CGC and 57.8% CAC) and leukemia (40.7% CGC and 59.3% CAC) genomic DNAs. 11705857

2001

dbSNP: rs1217691063
rs1217691063
0.070 GeneticVariation BEFREE Preponderance of methylenetetrahydrofolate reductase C677T homozygosity among leukemia patients intolerant to methotrexate. 12453860

2002

dbSNP: rs1800562
rs1800562
0.030 GeneticVariation BEFREE Its male-specificity, occurrence in childhood and the lack of a gene-dosage effect suggest that the C282Y association in childhood ALL may reflect the involvement of another HLA-linked gene in leukemia susceptibility. 12002748

2002

dbSNP: rs1275561861
rs1275561861
0.010 GeneticVariation BEFREE Its male-specificity, occurrence in childhood and the lack of a gene-dosage effect suggest that the C282Y association in childhood ALL may reflect the involvement of another HLA-linked gene in leukemia susceptibility. 12002748

2002

dbSNP: rs387906553
rs387906553
0.010 GeneticVariation BEFREE Collectively, these data suggest that expression of V72M NE is not sufficient to induce an SCN phenotype or leukemia in mice. 12384420

2002

dbSNP: rs1217691063
rs1217691063
0.070 GeneticVariation BEFREE Our results suggest that the MTHFR C677T polymorphism displays a similar distribution pattern in lymphoid and myeloid leukemias and that the frequency of the homozygote variant genotype (677TT) is lower in all leukemia types. 15068389

2003

dbSNP: rs11547328
rs11547328
0.010 GeneticVariation BEFREE Absence of R24C mutation of the CDK4 gene in leukemias and solid tumors. 12731669

2003

dbSNP: rs762613037
rs762613037
0.010 GeneticVariation BEFREE The bone marrow and/or peripheral blood from 126 patients with acute myeloid leukemia (AML), 57 with chronic myeloid leukemia (CML), 91 with acute lymphocytic leukemia (ALL), and 178 normal controls were analyzed using a polymerase chain reaction-restriction fragment length polymorphism (RFLP) assay to evaluate the association of the endostatin polymorphisms D104N (nucleotide 4349G --> A) with leukemia. 12693719

2003

dbSNP: rs771138120
rs771138120
0.010 GeneticVariation BEFREE Absence of R24C mutation of the CDK4 gene in leukemias and solid tumors. 12731669

2003

dbSNP: rs121913459
rs121913459
0.100 GeneticVariation BEFREE The resistance to the tyrosine kinase inhibitor imatinib in BCR/ABL-positive leukemias is mostly associated with mutations in the kinase domain of BCR/ABL, which include the most prevalent mutations E255K and T315I. 15194504

2004

dbSNP: rs1360131632
rs1360131632
0.030 GeneticVariation BEFREE The resistance to the tyrosine kinase inhibitor imatinib in BCR/ABL-positive leukemias is mostly associated with mutations in the kinase domain of BCR/ABL, which include the most prevalent mutations E255K and T315I. 15194504

2004

dbSNP: rs11545078
rs11545078
GGH
0.010 GeneticVariation BEFREE These studies demonstrate a substrate specific functional SNP (452C>T) in the human GGH gene that is associated with lower catalytic activity and higher accumulation of long-chain MTX-PG in leukaemia cells of patients treated with HDMTX. 15284538

2004

dbSNP: rs121912438
rs121912438
0.010 GeneticVariation BEFREE The effect of leukaemia inhibitory factor on SOD1 G93A murine amyotrophic lateral sclerosis. 12967646

2004