rs104894421
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
rs121434629
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs121913250
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
rs61753793
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
rs6413463
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
rs77375493
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Leukaemia</span> arising in a JAK2 V617F</span>-negative clone is TP53 independent and shows better survival.
|
28542718 |
2017 |
rs121913507
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Asp816Val mutation was found in 3.5% of cases of AML and Val560Gly mutation in 1 sample with acute biclonal leukemia.
|
25247397 |
2015 |
rs121913682
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Asp816Val mutation was found in 3.5% of cases of AML and Val560Gly mutation in 1 sample with acute biclonal leukemia.
|
25247397 |
2015 |
rs121913459
|
|
|
0.100 |
GeneticVariation |
BEFREE |
T315I mutation of BCR-ABL1 into human Philadelphia chromosome-positive leukemia cell lines by homologous recombination using the CRISPR/Cas9 system.
|
29967475 |
2018 |
rs121913514
|
|
|
0.030 |
GeneticVariation |
BEFREE |
N822K- or V560G-mutated KIT activation preferentially occurs in lipid rafts of the Golgi apparatus in leukemia cells.
|
31484543 |
2019 |
rs11547328
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Absence of R24C mutation of the CDK4 gene in leukemias and solid tumors.
|
12731669 |
2003 |
rs771138120
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Absence of R24C mutation of the CDK4 gene in leukemias and solid tumors.
|
12731669 |
2003 |
rs61754966
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Additionally we confirmed the higher incidence of the p.I171V mutation in the leukemia group (7/220) than among controls (12/2400) (p<0.0001).
|
24093751 |
2013 |
rs25489
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, Arg399Gln, Arg194Trp, and Arg280His may influence the susceptibilities of some leukemia type and race populations.
|
24363792 |
2013 |
rs10065633
|
|
|
0.010 |
GeneticVariation |
BEFREE |
All three htSNPs showed correlation with blood infection levels in malaria patients, and the rs10065633 polymorphism was associated with severe disease (P=0.02).
|
18200030 |
2008 |
rs121913459
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Allogeneic stem cell transplantation for patients harboring T315I BCR-ABL mutated leukemias.
|
21926354 |
2011 |
rs113488022
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Alternative BRAF mutations in BRAF V600E-negative hairy cell leukaemias.
|
24433452 |
2014 |
rs121913377
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Alternative BRAF mutations in BRAF V600E-negative hairy cell leukaemias.
|
24433452 |
2014 |
rs138817062
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although HIPK2 mutations (R861W and N951I) were found in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients, little is known about the underlying mechanisms by which HIPK2 mutations are associated with the pathogenesis of leukemia.
|
30755814 |
2019 |
rs121913459
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although many imatinib-resistant mutations respond well to second-generation TKIs, the threonine-to-isoleucine mutation at codon 315 of the breakpoint cluster region/v-abl Abelson murine leukemia viral oncogene protein fusion Bcr-Abl (T315I) is insensitive to all currently available TKIs.
|
20564073 |
2010 |
rs121913459
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although strategies to overcome resistance-mediated T315I mutation may improve the survival of BCR-ABL-positive leukemia patients, there is little information on cell-based studies.
|
20471447 |
2010 |
rs77375493
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among the patients with myelofibrosis, those with ASXL1 lesions were not distinguished from their wild-type counterparts with regard to JAK2 V617F status, exposure to chemotherapy or evolution to leukemia.
|
21712540 |
2011 |
rs2736098
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the probands, a significantly increased frequency of leukemia was found in the carriers of SNP rs2736098 (5p15, P = .03) and melanoma in the carriers of either SNP rs1512268 (8p21, P = .006) or SNP rs5759167 (22q13, P = .02).
|
21820706 |
2011 |
rs61754966
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Among these, an association with cancer was found most frequently for 657del5 (in leukemia/lymphoma and breast cancer) and I171V (in leukemia, breast, head and neck and colorectal cancers); however, other studies gave contradictory results.
|
18606567 |
2008 |
rs121913459
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Antitumor Effects of Blocking Protein Neddylation in T315I-BCR-ABL Leukemia Cells and Leukemia Stem Cells.
|
29321163 |
2018 |