Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs104894421
rs104894421
0.700 GeneticVariation UNIPROT

dbSNP: rs121434629
rs121434629
A 0.700 GeneticVariation CLINVAR

dbSNP: rs121913250
rs121913250
0.700 GeneticVariation UNIPROT

dbSNP: rs61753793
rs61753793
0.700 GeneticVariation UNIPROT

dbSNP: rs6413463
rs6413463
0.700 GeneticVariation UNIPROT

dbSNP: rs77375493
rs77375493
0.100 GeneticVariation BEFREE Leukaemia</span> arising in a JAK2 V617F</span>-negative clone is TP53 independent and shows better survival. 28542718

2017

dbSNP: rs121913507
rs121913507
KIT
0.040 GeneticVariation BEFREE Asp816Val mutation was found in 3.5% of cases of AML and Val560Gly mutation in 1 sample with acute biclonal leukemia. 25247397

2015

dbSNP: rs121913682
rs121913682
KIT
0.040 GeneticVariation BEFREE Asp816Val mutation was found in 3.5% of cases of AML and Val560Gly mutation in 1 sample with acute biclonal leukemia. 25247397

2015

dbSNP: rs121913459
rs121913459
0.100 GeneticVariation BEFREE T315I mutation of BCR-ABL1 into human Philadelphia chromosome-positive leukemia cell lines by homologous recombination using the CRISPR/Cas9 system. 29967475

2018

dbSNP: rs121913514
rs121913514
KIT
0.030 GeneticVariation BEFREE N822K- or V560G-mutated KIT activation preferentially occurs in lipid rafts of the Golgi apparatus in leukemia cells. 31484543

2019

dbSNP: rs11547328
rs11547328
0.010 GeneticVariation BEFREE Absence of R24C mutation of the CDK4 gene in leukemias and solid tumors. 12731669

2003

dbSNP: rs771138120
rs771138120
0.010 GeneticVariation BEFREE Absence of R24C mutation of the CDK4 gene in leukemias and solid tumors. 12731669

2003

dbSNP: rs61754966
rs61754966
NBN
0.030 GeneticVariation BEFREE Additionally we confirmed the higher incidence of the p.I171V mutation in the leukemia group (7/220) than among controls (12/2400) (p<0.0001). 24093751

2013

dbSNP: rs25489
rs25489
0.010 GeneticVariation BEFREE Additionally, Arg399Gln, Arg194Trp, and Arg280His may influence the susceptibilities of some leukemia type and race populations. 24363792

2013

dbSNP: rs10065633
rs10065633
0.010 GeneticVariation BEFREE All three htSNPs showed correlation with blood infection levels in malaria patients, and the rs10065633 polymorphism was associated with severe disease (P=0.02). 18200030

2008

dbSNP: rs121913459
rs121913459
0.100 GeneticVariation BEFREE Allogeneic stem cell transplantation for patients harboring T315I BCR-ABL mutated leukemias. 21926354

2011

dbSNP: rs113488022
rs113488022
0.040 GeneticVariation BEFREE Alternative BRAF mutations in BRAF V600E-negative hairy cell leukaemias. 24433452

2014

dbSNP: rs121913377
rs121913377
0.040 GeneticVariation BEFREE Alternative BRAF mutations in BRAF V600E-negative hairy cell leukaemias. 24433452

2014

dbSNP: rs138817062
rs138817062
PML
0.010 GeneticVariation BEFREE Although HIPK2 mutations (R861W and N951I) were found in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients, little is known about the underlying mechanisms by which HIPK2 mutations are associated with the pathogenesis of leukemia. 30755814

2019

dbSNP: rs121913459
rs121913459
0.100 GeneticVariation BEFREE Although many imatinib-resistant mutations respond well to second-generation TKIs, the threonine-to-isoleucine mutation at codon 315 of the breakpoint cluster region/v-abl Abelson murine leukemia viral oncogene protein fusion Bcr-Abl (T315I) is insensitive to all currently available TKIs. 20564073

2010

dbSNP: rs121913459
rs121913459
0.100 GeneticVariation BEFREE Although strategies to overcome resistance-mediated T315I mutation may improve the survival of BCR-ABL-positive leukemia patients, there is little information on cell-based studies. 20471447

2010

dbSNP: rs77375493
rs77375493
0.100 GeneticVariation BEFREE Among the patients with myelofibrosis, those with ASXL1 lesions were not distinguished from their wild-type counterparts with regard to JAK2 V617F status, exposure to chemotherapy or evolution to leukemia. 21712540

2011

dbSNP: rs2736098
rs2736098
0.010 GeneticVariation BEFREE Among the probands, a significantly increased frequency of leukemia was found in the carriers of SNP rs2736098 (5p15, P = .03) and melanoma in the carriers of either SNP rs1512268 (8p21, P = .006) or SNP rs5759167 (22q13, P = .02). 21820706

2011

dbSNP: rs61754966
rs61754966
NBN
0.030 GeneticVariation BEFREE Among these, an association with cancer was found most frequently for 657del5 (in leukemia/lymphoma and breast cancer) and I171V (in leukemia, breast, head and neck and colorectal cancers); however, other studies gave contradictory results. 18606567

2008

dbSNP: rs121913459
rs121913459
0.100 GeneticVariation BEFREE Antitumor Effects of Blocking Protein Neddylation in T315I-BCR-ABL Leukemia Cells and Leukemia Stem Cells. 29321163

2018