rs10065633
|
|
|
0.010 |
GeneticVariation |
BEFREE |
All three htSNPs showed correlation with blood infection levels in malaria patients, and the rs10065633 polymorphism was associated with severe disease (P=0.02).
|
18200030 |
2008 |
rs10251201
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The locus of rs974120 shows marks of transcriptional activity in leukemia according to ENCODE data. rs10251201 (7p21.3), rs9318227 (13q22.1), and rs10405859 (19q13.32) were associated with markers related to leukemogenesis and immune and inflammatory responses.
|
28375557 |
2017 |
rs10405859
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The locus of rs974120 shows marks of transcriptional activity in leukemia according to ENCODE data. rs10251201 (7p21.3), rs9318227 (13q22.1), and rs10405859 (19q13.32) were associated with markers related to leukemogenesis and immune and inflammatory responses.
|
28375557 |
2017 |
rs1042522
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Further studies showed no association between leukemia risk and p53 Arg72Pro polymorphism when stratified in subtypes of leukemias, ethnicities and sources of controls.
|
23029260 |
2012 |
rs1042522
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the results suggest that there is no association between TP53 Arg72Pro polymorphism and the risk of leukemia, but the CC genotype may increase the risk of ALL TP53 Arg72Pro polymorphism CC genotype may increase the risk of ALL but is not associated with AML.
|
27053289 |
2016 |
rs1045642
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These findings provide further evidence that the MDR1 C3435T variant may modify the susceptibility to leukemia.
|
22088099 |
2012 |
rs1045642
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that the MDR1 C3435T polymorphism associate with risk of leukaemia.
|
23731124 |
2013 |
rs104894230
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We successfully established a mouse model of human leukemia by transplanting bone marrow cells co-transfected with the K-ras (G12D) mutation and AML1/ETO fusion protein.
|
24480914 |
2014 |
rs104894421
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
rs1051266
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In genomic DNAs prepared from 105 leukemia (n = 54) and non-leukemia (n = 51) specimens, PCR amplifications and direct sequencing of exon 3 identified a high-frequency G to A single nucleotide polymorphism at position 80 that resulted in a change of arginine-27 to histidine-27.
|
11705857 |
2001 |
rs1057519753
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further analysis showed that JAK1 V658F cooperated in vivo with PML-RARA, causing a rapidly fatal leukemia in mice.
|
21436584 |
2011 |
rs1057519766
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia.
|
23878140 |
2013 |
rs1057519866
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we use a conditional-and-inducible leukaemia model to demonstrate that expression of NT5C2(R367Q), a highly prevalent relapsed-ALL NT5C2 mutation, induces resistance to chemotherapy with 6-mercaptopurine at the cost of impaired leukaemia cell growth and leukaemia-initiating cell activity.
|
29342136 |
2018 |
rs10740055
|
|
|
0.010 |
GeneticVariation |
BEFREE |
It was found that the variants rs10740055 of ARID5B and rs6964823 of IKZF1 act individually and additively as risk factors in the development of leukemia in the populations of Jammu and Kashmir in Northern India.
|
30810385 |
2019 |
rs10821936
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The heterozygous genotype in <i>ARID5B</i> (RefSNP: rs10821936) increased the risk for leukemia with <i>MLL</i>-rearrangement.
|
28781666 |
2017 |
rs10931910
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found a significant decrease in clearance (τ=-0.32, P=0.003) in solid tumor patients with rs10931910, although it failed to replicate in the leukemia cohort (τ=0.18, P=0.20).
|
24300566 |
2014 |
rs11079041
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Linkage disequilibrium existed between rs11079041 and rs2293157 in both leukemia and control groups (r(2) = 0.7).
|
22126101 |
2012 |
rs113017087
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The luciferase reporter assay showed that among the six SNPs tested, the rs75612255 C allele and rs113017087 C allele in promoter 1A as well as the rs138386816 T allele and rs115658307 T allele in promoter 1B significantly increased luciferase activity in the human erythromyeloblastoid leukaemia cell line K562.
|
28105931 |
2016 |
rs1130409
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Progression to secondary myelofibrosis/leukemia is influenced by exposure to cytoreductive agents, and caspase and BER polymorphisms {globally, CASP8 3'untranslated region [odds ratio (OR)=0.24; 95% confidence interval (CI), 0.08‑0.69], XRCC1 Arg194Trp [OR=3.58; 95% CI, 0.98‑13.01]; for essential thrombocythemia patients CASP9 Arg173His [OR=11.27; 95% CI, 1.13‑112.28], APEX1 Asp148Glu [OR=0.28; 95% CI, 0.74‑1.03], and XRCC1 Arg194Trp [OR=6.60; 95% CI, 1.60‑27.06]}.
|
30320340 |
2018 |
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the results suggest that there is no association between TP53 Arg72Pro polymorphism and the risk of leukemia, but the CC genotype may increase the risk of ALL TP53 Arg72Pro polymorphism CC genotype may increase the risk of ALL but is not associated with AML.
|
27053289 |
2016 |
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Further studies showed no association between leukemia risk and p53 Arg72Pro polymorphism when stratified in subtypes of leukemias, ethnicities and sources of controls.
|
23029260 |
2012 |
rs113488022
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Alternative BRAF mutations in BRAF V600E-negative hairy cell leukaemias.
|
24433452 |
2014 |
rs113488022
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We assessed phospho-ERK expression in 37 patients with hairy cell leukemia and 44 patients with neoplasms mimicking hairy cell leukemia (40 splenic marginal zone lymphoma, 2 hairy cell leukemia-variant and 2 splenic lymphoma/leukemia unclassifiable) using immunohistochemistry on routine biopsies and/or Western blotting on purified leukemic cells, and correlated the phospho-ERK status with the BRAF-V600E mutation status.
|
23349307 |
2013 |
rs113488022
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our results confirm that BRAF V600E-positive HCL is a relatively rare disorder in the Japanese leukemia patient population.
|
30043333 |
2018 |
rs113488022
|
|
|
0.040 |
GeneticVariation |
BEFREE |
None of the 195 patients with other peripheral B-cell lymphomas or leukemias who were evaluated carried the BRAF V600E variant, including 38 patients with splenic marginal-zone lymphomas or unclassifiable splenic lymphomas or leukemias.
|
21663470 |
2011 |