Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10065633
rs10065633
0.010 GeneticVariation BEFREE All three htSNPs showed correlation with blood infection levels in malaria patients, and the rs10065633 polymorphism was associated with severe disease (P=0.02). 18200030

2008

dbSNP: rs10251201
rs10251201
0.010 GeneticVariation BEFREE The locus of rs974120 shows marks of transcriptional activity in leukemia according to ENCODE data. rs10251201 (7p21.3), rs9318227 (13q22.1), and rs10405859 (19q13.32) were associated with markers related to leukemogenesis and immune and inflammatory responses. 28375557

2017

dbSNP: rs10405859
rs10405859
0.010 GeneticVariation BEFREE The locus of rs974120 shows marks of transcriptional activity in leukemia according to ENCODE data. rs10251201 (7p21.3), rs9318227 (13q22.1), and rs10405859 (19q13.32) were associated with markers related to leukemogenesis and immune and inflammatory responses. 28375557

2017

dbSNP: rs1042522
rs1042522
0.020 GeneticVariation BEFREE Further studies showed no association between leukemia risk and p53 Arg72Pro polymorphism when stratified in subtypes of leukemias, ethnicities and sources of controls. 23029260

2012

dbSNP: rs1042522
rs1042522
0.020 GeneticVariation BEFREE In conclusion, the results suggest that there is no association between TP53 Arg72Pro polymorphism and the risk of leukemia, but the CC genotype may increase the risk of ALL TP53 Arg72Pro polymorphism CC genotype may increase the risk of ALL but is not associated with AML. 27053289

2016

dbSNP: rs1045642
rs1045642
0.020 GeneticVariation BEFREE These findings provide further evidence that the MDR1 C3435T variant may modify the susceptibility to leukemia. 22088099

2012

dbSNP: rs1045642
rs1045642
0.020 GeneticVariation BEFREE This meta-analysis suggests that the MDR1 C3435T polymorphism associate with risk of leukaemia. 23731124

2013

dbSNP: rs104894230
rs104894230
0.010 GeneticVariation BEFREE We successfully established a mouse model of human leukemia by transplanting bone marrow cells co-transfected with the K-ras (G12D) mutation and AML1/ETO fusion protein. 24480914

2014

dbSNP: rs104894421
rs104894421
0.700 GeneticVariation UNIPROT

dbSNP: rs1051266
rs1051266
0.010 GeneticVariation BEFREE In genomic DNAs prepared from 105 leukemia (n = 54) and non-leukemia (n = 51) specimens, PCR amplifications and direct sequencing of exon 3 identified a high-frequency G to A single nucleotide polymorphism at position 80 that resulted in a change of arginine-27 to histidine-27. 11705857

2001

dbSNP: rs1057519753
rs1057519753
0.010 GeneticVariation BEFREE Further analysis showed that JAK1 V658F cooperated in vivo with PML-RARA, causing a rapidly fatal leukemia in mice. 21436584

2011

dbSNP: rs1057519766
rs1057519766
0.010 GeneticVariation BEFREE Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia. 23878140

2013

dbSNP: rs1057519866
rs1057519866
0.010 GeneticVariation BEFREE Here we use a conditional-and-inducible leukaemia model to demonstrate that expression of NT5C2(R367Q), a highly prevalent relapsed-ALL NT5C2 mutation, induces resistance to chemotherapy with 6-mercaptopurine at the cost of impaired leukaemia cell growth and leukaemia-initiating cell activity. 29342136

2018

dbSNP: rs10740055
rs10740055
0.010 GeneticVariation BEFREE It was found that the variants rs10740055 of ARID5B and rs6964823 of IKZF1 act individually and additively as risk factors in the development of leukemia in the populations of Jammu and Kashmir in Northern India. 30810385

2019

dbSNP: rs10821936
rs10821936
0.010 GeneticVariation BEFREE The heterozygous genotype in <i>ARID5B</i> (RefSNP: rs10821936) increased the risk for leukemia with <i>MLL</i>-rearrangement. 28781666

2017

dbSNP: rs10931910
rs10931910
0.010 GeneticVariation BEFREE We found a significant decrease in clearance (τ=-0.32, P=0.003) in solid tumor patients with rs10931910, although it failed to replicate in the leukemia cohort (τ=0.18, P=0.20). 24300566

2014

dbSNP: rs11079041
rs11079041
0.010 GeneticVariation BEFREE Linkage disequilibrium existed between rs11079041 and rs2293157 in both leukemia and control groups (r(2) = 0.7). 22126101

2012

dbSNP: rs113017087
rs113017087
APC
0.010 GeneticVariation BEFREE The luciferase reporter assay showed that among the six SNPs tested, the rs75612255 C allele and rs113017087 C allele in promoter 1A as well as the rs138386816 T allele and rs115658307 T allele in promoter 1B significantly increased luciferase activity in the human erythromyeloblastoid leukaemia cell line K562. 28105931

2016

dbSNP: rs1130409
rs1130409
0.010 GeneticVariation BEFREE Progression to secondary myelofibrosis/leukemia is influenced by exposure to cytoreductive agents, and caspase and BER polymorphisms {globally, CASP8 3'untranslated region [odds ratio (OR)=0.24; 95% confidence interval (CI), 0.08‑0.69], XRCC1 Arg194Trp [OR=3.58; 95% CI, 0.98‑13.01]; for essential thrombocythemia patients CASP9 Arg173His [OR=11.27; 95% CI, 1.13‑112.28], APEX1 Asp148Glu [OR=0.28; 95% CI, 0.74‑1.03], and XRCC1 Arg194Trp [OR=6.60; 95% CI, 1.60‑27.06]}. 30320340

2018

dbSNP: rs1131691014
rs1131691014
0.020 GeneticVariation BEFREE In conclusion, the results suggest that there is no association between TP53 Arg72Pro polymorphism and the risk of leukemia, but the CC genotype may increase the risk of ALL TP53 Arg72Pro polymorphism CC genotype may increase the risk of ALL but is not associated with AML. 27053289

2016

dbSNP: rs1131691014
rs1131691014
0.020 GeneticVariation BEFREE Further studies showed no association between leukemia risk and p53 Arg72Pro polymorphism when stratified in subtypes of leukemias, ethnicities and sources of controls. 23029260

2012

dbSNP: rs113488022
rs113488022
0.040 GeneticVariation BEFREE Alternative BRAF mutations in BRAF V600E-negative hairy cell leukaemias. 24433452

2014

dbSNP: rs113488022
rs113488022
0.040 GeneticVariation BEFREE We assessed phospho-ERK expression in 37 patients with hairy cell leukemia and 44 patients with neoplasms mimicking hairy cell leukemia (40 splenic marginal zone lymphoma, 2 hairy cell leukemia-variant and 2 splenic lymphoma/leukemia unclassifiable) using immunohistochemistry on routine biopsies and/or Western blotting on purified leukemic cells, and correlated the phospho-ERK status with the BRAF-V600E mutation status. 23349307

2013

dbSNP: rs113488022
rs113488022
0.040 GeneticVariation BEFREE Our results confirm that BRAF V600E-positive HCL is a relatively rare disorder in the Japanese leukemia patient population. 30043333

2018

dbSNP: rs113488022
rs113488022
0.040 GeneticVariation BEFREE None of the 195 patients with other peripheral B-cell lymphomas or leukemias who were evaluated carried the BRAF V600E variant, including 38 patients with splenic marginal-zone lymphomas or unclassifiable splenic lymphomas or leukemias. 21663470

2011