|
rs4132601
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We demonstrated the association of IKZF1 polymorphism rs4132601 T/G with increased risk of ALL among Tunisian pediatric cohort, with altered phenotypic changes among ALL patients.
|
31604453 |
2019 |
|
rs4132601
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, a borderline association was found between IKZF1 rs4132601 T>G variant and ALL risk.
|
28768142 |
2017 |
|
rs4132601
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings provide the rst evidence that SNPs ARID5B- rs10821936 and IKZF1-rs4132601 are associated with decreased B-lineage ALL susceptibility in Indian children.
|
27644650 |
2016 |
|
rs4132601
|
|
|
0.100 |
GeneticVariation |
BEFREE |
On the other hand, the rs4132601 G allele increased the risk of ALL (OR = 1.86, 95 % CI = 1.28-2.96; p = 0.0011) in comparison with the T allele.
|
26790447 |
2016 |
|
rs4132601
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results, which are consistent with findings in European populations, show that 3 SNPs, i.e., rs4132601 (P = .00116, odds ratio [OR] = 2.78, 95% confidence interval [CI] = [1.42, 5.87]), rs7089424 (P = .0022, OR = 0.49, 95% CI = [0.31, 0.79]), and rs2239633 (P = .0010, OR = 0.47, 95% CI = [0.29, 0.75]) are significantly associated with a higher risk of developing pediatric ALL (P < .05).
|
27184773 |
2016 |
|
rs4132601
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These SNPs are located at CDKN2A (rs3731217) and IKZF1 (rs4132601), genes frequently lost in ALL, and at CEBPE (rs2239633), ARID5B (rs7089424), PIP4K2A (rs10764338), and GATA3 (rs3824662), genes located on chromosomes gained in high-hyperdiploid ALL.
|
26575185 |
2015 |
|
rs4132601
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results suggested that rs4132601 was associated with an increased ALL risk.
|
25012940 |
2015 |
|
rs4132601
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results of the analysis provide statistically significant support for an association between the rs4132601 polymorphic site and age at diagnosis of childhood ALL (p = 0.04).
|
24597983 |
2014 |
|
rs4132601
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Consistent with findings in European populations, rs4132601 genotype was significantly associated with risk of ALL (odds ratio [OR] = 1.57, 95% confidence interval [CI]: 1.01-2.44; p = 0.04), and rs10821938 genotype was significantly associated with B-cell precursor ALL (OR = 0.73, 95% CI: 0.55-0.97; p = 0.03).
|
20919861 |
2010 |
|
rs4132601
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We identified risk loci for ALL at 7p12.2 (IKZF1, rs4132601, odds ratio (OR) = 1.69, P = 1.20 x 10(-19)), 10q21.2 (ARID5B, rs7089424, OR = 1.65, P = 6.69 x 10(-19)) and 14q11.2 (CEBPE, rs2239633, OR = 1.34, P = 2.88 x 10(-7)).
|
19684604 |
2009 |