|
rs7089424
|
|
|
0.090 |
GeneticVariation |
BEFREE |
ARID5B rs7089424 and rs10994982 might serve as genetic susceptibility markers for B-ALL in Chinese pediatric population.
|
31274788 |
2019 |
|
rs7089424
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The CAG haplotype (rs10821936, rs10994982, rs7089424) was strongly associated with ALL risk in our population (p < 0.00001).
|
31227872 |
2019 |
|
rs7089424
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The current case-control study evaluated variants in ARID5B (rs7089424, rs10821936), IKZF1 (rs4132601) and CEBPE (rs2239633) genes, which appear most significantly associated with risk of developing childhood B-lineage ALL.
|
27644650 |
2016 |
|
rs7089424
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Our results, which are consistent with findings in European populations, show that 3 SNPs, i.e., rs4132601 (P = .00116, odds ratio [OR] = 2.78, 95% confidence interval [CI] = [1.42, 5.87]), rs7089424 (P = .0022, OR = 0.49, 95% CI = [0.31, 0.79]), and rs2239633 (P = .0010, OR = 0.47, 95% CI = [0.29, 0.75]) are significantly associated with a higher risk of developing pediatric ALL (P < .05).
|
27184773 |
2016 |
|
rs7089424
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The distribution of genotype rs7073837 in ARID5B significantly differed between ALL and controls (P=0.046), while those of IKZF1 (rs6964823, rs4132601, and rs6944602) and ARID5B (rs10740055 and rs7089424) did not.
|
24200646 |
2014 |
|
rs7089424
|
|
|
0.090 |
GeneticVariation |
BEFREE |
These results indicate that SNPs rs10994982 and rs7089424 are indeed significantly associated with increased risk of childhood ALL.
|
25124600 |
2014 |
|
rs7089424
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In an attempt to replicate the findings of 2 recent genome-wide association studies in a French-Canadian cohort, we confirmed the association of 5 SNPs [rs7073837 (P=4.2 x 10(-4)), rs10994982 (P=3.8 x 10(-4)), rs10740055 (P=1.6 x 10(-5)), rs10821936 (P=1.7 x 10(-7)) and rs7089424 (P=3.6 x 10(-7))] in the ARID5B gene with childhood acute lymphoblastic leukemia.
|
20460642 |
2010 |
|
rs7089424
|
|
|
0.090 |
GeneticVariation |
BEFREE |
To explore the impact of these variants on ALL risk in the Thai population, we genotyped 190 cases of ALL and 182 controls for SNPs rs4132601 (7p12.2), rs3731217 (9p21.3), rs7089424 and rs10821938 (10q21.2), and rs2239633 (14q11.2).
|
20919861 |
2010 |
|
rs7089424
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We identified risk loci for ALL at 7p12.2 (IKZF1, rs4132601, odds ratio (OR) = 1.69, P = 1.20 x 10(-19)), 10q21.2 (ARID5B, rs7089424, OR = 1.65, P = 6.69 x 10(-19)) and 14q11.2 (CEBPE, rs2239633, OR = 1.34, P = 2.88 x 10(-7)).
|
19684604 |
2009 |