Gene: FLT3 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913487
rs121913487
FLT3
0.800 GeneticVariation UNIPROT

dbSNP: rs121913486
rs121913486
FLT3
T 0.700 CausalMutation CLINVAR

dbSNP: rs398122514
rs398122514
FLT3
TGGATCC 0.700 CausalMutation CLINVAR

dbSNP: rs121913487
rs121913487
FLT3
T 0.800 CausalMutation CLINVAR Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. 11290608

2001
dbSNP: rs121913487
rs121913487
FLT3
C 0.800 CausalMutation CLINVAR Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. 11290608

2001
dbSNP: rs121913488
rs121913488
FLT3
T 0.740 CausalMutation CLINVAR Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. 11290608

2001
dbSNP: rs121913488
rs121913488
FLT3
G 0.740 CausalMutation CLINVAR Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. 11290608

2001
dbSNP: rs121913488
rs121913488
FLT3
A 0.740 CausalMutation CLINVAR Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. 11290608

2001
dbSNP: rs121909646
rs121909646
FLT3
A 0.700 CausalMutation CLINVAR Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. 11290608

2001
dbSNP: rs121913232
rs121913232
FLT3
0.710 GeneticVariation BEFREE Recently, novel mutations within the activation loop were identified in patients with AML: deletion of isoleucine 836 (Ile836del) and an exchange of isoleucine 836 to methionine plus an arginine insertion (Ile836Met+Arg). 12663439

2003
dbSNP: rs121913488
rs121913488
FLT3
G 0.740 CausalMutation CLINVAR Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells. 14604974

2004
dbSNP: rs121909646
rs121909646
FLT3
A 0.700 CausalMutation CLINVAR Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells. 14604974

2004
dbSNP: rs1057520023
rs1057520023
FLT3
C 0.700 GeneticVariation CLINVAR Acquisition of FLT3 or N-ras mutations is frequently associated with progression of myelodysplastic syndrome to acute myeloid leukemia. 14737077

2004
dbSNP: rs121913487
rs121913487
FLT3
C 0.800 CausalMutation CLINVAR Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518. 15256420

2004
dbSNP: rs121913487
rs121913487
FLT3
T 0.800 CausalMutation CLINVAR Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518. 15256420

2004
dbSNP: rs121913488
rs121913488
FLT3
G 0.740 CausalMutation CLINVAR Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518. 15256420

2004
dbSNP: rs121913488
rs121913488
FLT3
T 0.740 CausalMutation CLINVAR Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518. 15256420

2004
dbSNP: rs121913488
rs121913488
FLT3
A 0.740 CausalMutation CLINVAR Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518. 15256420

2004
dbSNP: rs121909646
rs121909646
FLT3
A 0.700 CausalMutation CLINVAR Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518. 15256420

2004
dbSNP: rs376588714
rs376588714
FLT3
0.710 GeneticVariation BEFREE Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML). 15345593

2005
dbSNP: rs121913487
rs121913487
FLT3
C 0.800 CausalMutation CLINVAR FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression. 15374878

2005
dbSNP: rs121913487
rs121913487
FLT3
T 0.800 CausalMutation CLINVAR FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression. 15374878

2005
dbSNP: rs749281035
rs749281035
FLT3
T 0.700 GeneticVariation CLINVAR A novel FLT3 activation loop mutation N841K in acute myeloblastic leukemia. 15625552

2005
dbSNP: rs991132188
rs991132188
FLT3
C 0.700 GeneticVariation CLINVAR Development of a human acute myeloid leukaemia screening panel and consequent identification of novel gene mutation in FLT3 and CCND3. 15667533

2005
dbSNP: rs1057519726
rs1057519726
FLT3
G 0.700 CausalMutation CLINVAR Prognostic significance of FLT3 mutations in pediatric non-promyelocytic acute myeloid leukemia. 15863200

2005