Gene: FLT3 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913487
rs121913487
FLT3
0.800 GeneticVariation UNIPROT

dbSNP: rs121913486
rs121913486
FLT3
T 0.700 CausalMutation CLINVAR

dbSNP: rs398122514
rs398122514
FLT3
TGGATCC 0.700 CausalMutation CLINVAR

dbSNP: rs749281035
rs749281035
FLT3
T 0.700 GeneticVariation CLINVAR A novel FLT3 activation loop mutation N841K in acute myeloblastic leukemia. 15625552

2005
dbSNP: rs121913487
rs121913487
FLT3
C 0.800 CausalMutation CLINVAR A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. 16857985

2006
dbSNP: rs121913487
rs121913487
FLT3
T 0.800 CausalMutation CLINVAR A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. 16857985

2006
dbSNP: rs121913488
rs121913488
FLT3
G 0.740 CausalMutation CLINVAR A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. 16857985

2006
dbSNP: rs121913488
rs121913488
FLT3
T 0.740 CausalMutation CLINVAR A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. 16857985

2006
dbSNP: rs121913488
rs121913488
FLT3
A 0.740 CausalMutation CLINVAR A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. 16857985

2006
dbSNP: rs121909646
rs121909646
FLT3
G 0.700 CausalMutation CLINVAR A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. 16857985

2006
dbSNP: rs121909646
rs121909646
FLT3
A 0.700 CausalMutation CLINVAR A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. 16857985

2006
dbSNP: rs1057520023
rs1057520023
FLT3
C 0.700 GeneticVariation CLINVAR Acquisition of FLT3 or N-ras mutations is frequently associated with progression of myelodysplastic syndrome to acute myeloid leukemia. 14737077

2004
dbSNP: rs121913487
rs121913487
FLT3
T 0.800 CausalMutation CLINVAR Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. 11290608

2001
dbSNP: rs121913487
rs121913487
FLT3
C 0.800 CausalMutation CLINVAR Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. 11290608

2001
dbSNP: rs121913488
rs121913488
FLT3
T 0.740 CausalMutation CLINVAR Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. 11290608

2001
dbSNP: rs121913488
rs121913488
FLT3
G 0.740 CausalMutation CLINVAR Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. 11290608

2001
dbSNP: rs121913488
rs121913488
FLT3
A 0.740 CausalMutation CLINVAR Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. 11290608

2001
dbSNP: rs121909646
rs121909646
FLT3
A 0.700 CausalMutation CLINVAR Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. 11290608

2001
dbSNP: rs121913487
rs121913487
FLT3
T 0.800 CausalMutation CLINVAR Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. 23430109

2013
dbSNP: rs121913487
rs121913487
FLT3
C 0.800 CausalMutation CLINVAR Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. 23430109

2013
dbSNP: rs121913488
rs121913488
FLT3
G 0.740 CausalMutation CLINVAR Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. 23430109

2013
dbSNP: rs121913488
rs121913488
FLT3
T 0.740 CausalMutation CLINVAR Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. 23430109

2013
dbSNP: rs121913488
rs121913488
FLT3
A 0.740 CausalMutation CLINVAR Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. 23430109

2013
dbSNP: rs376588714
rs376588714
FLT3
C 0.710 GeneticVariation CLINVAR Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. 23430109

2013
dbSNP: rs1057519762
rs1057519762
FLT3
G 0.700 GeneticVariation CLINVAR Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. 23430109

2013