Gene: FLT3 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057519726
rs1057519726
FLT3
A 0.700 GeneticVariation CLINVAR Novel observation of three FLT3 codons mutated in tandem in an elderly acute myeloid leukaemia patient. 16371029

2006
dbSNP: rs1057519726
rs1057519726
FLT3
C 0.700 GeneticVariation CLINVAR Prospective study of 174 de novo acute myelogenous leukemias according to the WHO classification: subtypes, cytogenetic features and FLT3 mutations. 16573742

2006
dbSNP: rs1057519726
rs1057519726
FLT3
G 0.700 CausalMutation CLINVAR Mutational landscape of AML with normal cytogenetics: biological and clinical implications. 23261068

2013
dbSNP: rs1057519726
rs1057519726
FLT3
G 0.700 CausalMutation CLINVAR Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation. 22368270

2012
dbSNP: rs1057519726
rs1057519726
FLT3
G 0.700 CausalMutation CLINVAR Prognostic significance of FLT3 mutations in pediatric non-promyelocytic acute myeloid leukemia. 15863200

2005
dbSNP: rs1057519726
rs1057519726
FLT3
G 0.700 CausalMutation CLINVAR Continuing aspirin in the perioperative patient. 22504186

2012
dbSNP: rs1057519726
rs1057519726
FLT3
G 0.700 CausalMutation CLINVAR The importance of relative mutant level for evaluating impact on outcome of KIT, FLT3 and CBL mutations in core-binding factor acute myeloid leukemia. 23783394

2013
dbSNP: rs1057519726
rs1057519726
FLT3
G 0.700 CausalMutation CLINVAR Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia. 23321257

2013
dbSNP: rs1057519726
rs1057519726
FLT3
G 0.700 CausalMutation CLINVAR The role of kinase inhibitors in the treatment of patients with acute myeloid leukemia. 23714533

2013
dbSNP: rs1057519762
rs1057519762
FLT3
G 0.700 GeneticVariation CLINVAR Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. 23430109

2013
dbSNP: rs1057519762
rs1057519762
FLT3
G 0.700 GeneticVariation CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184

2012
dbSNP: rs1057519762
rs1057519762
FLT3
G 0.700 GeneticVariation CLINVAR Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies. 24619500

2014
dbSNP: rs1057519763
rs1057519763
FLT3
AA 0.700 GeneticVariation CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184

2012
dbSNP: rs1057519764
rs1057519764
FLT3
0.710 GeneticVariation BEFREE Targeted next-generation sequencing at the time of AML progression on gilteritinib identified treatment-emergent mutations that activate RAS/MAPK pathway signaling, most commonly in <i>NRAS</i> or <i>KRAS.</i> Less frequently, secondary <i>FLT3</i>-F691L gatekeeper mutations or <i>BCR-ABL1</i> fusions were identified at progression. 31088841

2019
dbSNP: rs1057519764
rs1057519764
FLT3
T 0.710 GeneticVariation CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184

2012
dbSNP: rs1057519764
rs1057519764
FLT3
C 0.710 GeneticVariation CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184

2012
dbSNP: rs1057519765
rs1057519765
FLT3
A 0.700 GeneticVariation CLINVAR Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies. 24619500

2014
dbSNP: rs1057519765
rs1057519765
FLT3
A 0.700 GeneticVariation CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184

2012
dbSNP: rs1057519765
rs1057519765
FLT3
A 0.700 GeneticVariation CLINVAR Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. 23430109

2013
dbSNP: rs1057519766
rs1057519766
FLT3
0.720 GeneticVariation BEFREE Gene expression analysis of AML patients with CBFB/MYH11 rearrangement and FLT3 N676K mutation showed a trend toward a specific expression profile. 23878140

2013
dbSNP: rs1057519766
rs1057519766
FLT3
0.720 GeneticVariation BEFREE Moreover, further experiments investigating molecular mechanisms for leukemogenesis induced by FLT3-N676K mutation and clinical evaluation of FLT3 inhibitors in FLT3-N676K-positive AML seem warranted. 26891877

2016
dbSNP: rs1057519766
rs1057519766
FLT3
C 0.720 GeneticVariation CLINVAR Gene expression analysis of AML patients with CBFB/MYH11 rearrangement and FLT3 N676K mutation showed a trend toward a specific expression profile. 23878140

2013
dbSNP: rs1057519766
rs1057519766
FLT3
T 0.720 GeneticVariation CLINVAR Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies. 24619500

2014
dbSNP: rs1057519766
rs1057519766
FLT3
T 0.720 GeneticVariation CLINVAR Gene expression analysis of AML patients with CBFB/MYH11 rearrangement and FLT3 N676K mutation showed a trend toward a specific expression profile. 23878140

2013
dbSNP: rs1057519766
rs1057519766
FLT3
C 0.720 GeneticVariation CLINVAR Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies. 24619500

2014