rs121913487
|
|
|
0.800 |
GeneticVariation |
UNIPROT |
|
|
|
rs121913487
|
|
T |
0.800 |
CausalMutation |
CLINVAR |
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies.
|
11290608 |
2001 |
rs121913487
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies.
|
11290608 |
2001 |
rs121913487
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518.
|
15256420 |
2004 |
rs121913487
|
|
T |
0.800 |
CausalMutation |
CLINVAR |
Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518.
|
15256420 |
2004 |
rs121913487
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression.
|
15374878 |
2005 |
rs121913487
|
|
T |
0.800 |
CausalMutation |
CLINVAR |
FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression.
|
15374878 |
2005 |
rs121913487
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy.
|
16857985 |
2006 |
rs121913487
|
|
T |
0.800 |
CausalMutation |
CLINVAR |
A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy.
|
16857985 |
2006 |
rs121913487
|
|
T |
0.800 |
CausalMutation |
CLINVAR |
Recurring mutations found by sequencing an acute myeloid leukemia genome.
|
19657110 |
2009 |
rs121913487
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
Recurring mutations found by sequencing an acute myeloid leukemia genome.
|
19657110 |
2009 |
rs121913487
|
|
T |
0.800 |
CausalMutation |
CLINVAR |
Phase IIB trial of oral Midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3.
|
20733134 |
2010 |
rs121913487
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
Phase IIB trial of oral Midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3.
|
20733134 |
2010 |
rs121913487
|
|
T |
0.800 |
CausalMutation |
CLINVAR |
Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation.
|
22368270 |
2012 |
rs121913487
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation.
|
22368270 |
2012 |
rs121913487
|
|
T |
0.800 |
CausalMutation |
CLINVAR |
Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia.
|
22504183 |
2012 |
rs121913487
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia.
|
22504183 |
2012 |
rs121913487
|
|
T |
0.800 |
CausalMutation |
CLINVAR |
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia.
|
22504184 |
2012 |
rs121913487
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia.
|
22504184 |
2012 |
rs121913487
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
Mutational landscape of AML with normal cytogenetics: biological and clinical implications.
|
23261068 |
2013 |
rs121913487
|
|
T |
0.800 |
CausalMutation |
CLINVAR |
Mutational landscape of AML with normal cytogenetics: biological and clinical implications.
|
23261068 |
2013 |
rs121913487
|
|
T |
0.800 |
CausalMutation |
CLINVAR |
Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia.
|
23321257 |
2013 |
rs121913487
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia.
|
23321257 |
2013 |
rs121913487
|
|
T |
0.800 |
CausalMutation |
CLINVAR |
Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD.
|
23430109 |
2013 |
rs121913487
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD.
|
23430109 |
2013 |