rs121912651
|
|
A |
0.710 |
CausalMutation |
CLINVAR |
|
|
|
rs1057519975
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We previously identified a case of human acute myelogenous leukemia (AML) in which both alleles of the p53 gene had undergone independent missense mutations (at codons 135 cys to ser and 246 met to val).
|
1918170 |
1991 |
rs483352695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We previously identified a case of human acute myelogenous leukemia (AML) in which both alleles of the p53 gene had undergone independent missense mutations (at codons 135 cys to ser and 246 met to val).
|
1918170 |
1991 |
rs587782529
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The novel somatic mutation, R337G (16900C>G), was discovered in myelodysplastic syndrome with transformation to acute myeloblastic leukemia, developing as the third primary in the LFS child.
|
19714490 |
2009 |
rs121912651
|
|
A |
0.710 |
GeneticVariation |
CLINVAR |
p53 is critical for the Aurora B kinase inhibitor-mediated apoptosis in acute myelogenous leukemia cells.
|
20013323 |
2010 |
rs121912651
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We have recently established the MV4-11 acute myelogenous leukemia (AML) subline, designated as MV4-11 TP53 R248W, which possesses a missense mutation (CGG→TGG; R248W) in the TP53 gene, leading to inactivation of this transcription factor.
|
21550660 |
2011 |
rs886039484
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We suggest that SNPs in the P53 pathway, especially the P21 ser31arg polymorphism and combined polymorphisms especially the P21/ MDM2 might be genetic susceptibility factors in the pathogenesis of AML.
|
23167335 |
2012 |
rs1042522
|
|
|
0.020 |
GeneticVariation |
BEFREE |
There is no significant association of P53 arg72pro polymorphism on the risk of AML.
|
23167335 |
2012 |
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
There is no significant association of P53 arg72pro polymorphism on the risk of AML.
|
23167335 |
2012 |
rs878854066
|
|
|
0.020 |
GeneticVariation |
BEFREE |
There is no significant association of P53 arg72pro polymorphism on the risk of AML.
|
23167335 |
2012 |
rs1057520001
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We suggest that SNPs in the P53 pathway, especially the P21 ser31arg polymorphism and combined polymorphisms especially the P21/ MDM2 might be genetic susceptibility factors in the pathogenesis of AML.
|
23167335 |
2012 |
rs11540652
|
|
T |
0.710 |
GeneticVariation |
CLINVAR |
Prognostic significance of TP53 mutations and single nucleotide polymorphisms in acute myeloid leukemia: a case series and literature review.
|
24641375 |
2014 |
rs11540652
|
|
T |
0.710 |
GeneticVariation |
CLINVAR |
Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients.
|
24487413 |
2014 |
rs11540652
|
|
T |
0.710 |
GeneticVariation |
CLINVAR |
Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice.
|
24381225 |
2014 |
rs121912651
|
|
A |
0.710 |
GeneticVariation |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
rs1057519747
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice.
|
24381225 |
2014 |
rs1057519747
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients.
|
24487413 |
2014 |
rs1057519747
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
Prognostic significance of TP53 mutations and single nucleotide polymorphisms in acute myeloid leukemia: a case series and literature review.
|
24641375 |
2014 |
rs121912666
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice.
|
24381225 |
2014 |
rs121912666
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients.
|
24487413 |
2014 |
rs121912666
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
Prognostic significance of TP53 mutations and single nucleotide polymorphisms in acute myeloid leukemia: a case series and literature review.
|
24641375 |
2014 |
rs121913343
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients.
|
24487413 |
2014 |
rs121913343
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
Prognostic significance of TP53 mutations and single nucleotide polymorphisms in acute myeloid leukemia: a case series and literature review.
|
24641375 |
2014 |
rs121913343
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice.
|
24381225 |
2014 |
rs28934576
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients.
|
24487413 |
2014 |