DisGeNET - a database of gene-disease associations

Leukemia, Myelocytic, Acute, C0023467

Variant: rs1057519762 ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs1057519762

FLT3

0.700

GeneticVariation

CLINVAR

Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies.

24619500

2014

dbSNP:

rs1057519762

FLT3

0.700

GeneticVariation

CLINVAR

Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD.

23430109

2013

dbSNP:

rs1057519762

FLT3

0.700

GeneticVariation

CLINVAR

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia.

22504184

2012