Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1217691063
rs1217691063
0.080 GeneticVariation BEFREE Our objective was to determine the association between the methylenetetrahydrofolate reductase polymorphisms (C677T and A1298C) and the risk of developing acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), acute myeloid leukemia (AML), and multiple myelomas (MM) in Latinos. 31188929

2019

dbSNP: rs1217691063
rs1217691063
0.080 GeneticVariation BEFREE Conversely, the overall data failed to indicate a significant association of C677T or A1298C polymorphisms with AML risk under any model. 25080853

2014

dbSNP: rs1217691063
rs1217691063
0.080 GeneticVariation BEFREE The aim of this study is to derive a more precise estimation of the association between MTHFR (C677T and A1298C) polymorphisms and acute myeloid leukemia risk. 24586405

2014

dbSNP: rs1217691063
rs1217691063
0.080 GeneticVariation BEFREE The aim of this case-control study was to evaluate the association of the C677T MTHFR gene polymorphism with acute myeloid leukaemia (AML), acute lymphoblastic leukaemia (ALL), chronic myeloid leukaemia (CML) and chronic lymphocytic leukaemia (CLL). 22441130

2012

dbSNP: rs1217691063
rs1217691063
0.080 GeneticVariation BEFREE We investigated the association between polymorphisms in key folate metabolism enzymes (MTHFR 677 C>T, MTHFR 1298 A>C, SHMT1 1420 C>T, MTR 2756 A>G, TS 1494del6, and TS 28bp repeat) in 939 cases of childhood acute lymphoblastic leukemia (ALL) and 89 cases of acute myeloid leukemia (AML) recruited into the United Kingdom Childhood Cancer Study. 20101025

2010

dbSNP: rs1217691063
rs1217691063
0.080 GeneticVariation BEFREE The authors have conducted a study to test whether 677C-->T and/or 1298A-->C polymorphisms of MTHFR would play an additional role in susceptibility of acute myeloid leukemia (AML) in DS children. 19065440

2008

dbSNP: rs1217691063
rs1217691063
0.080 GeneticVariation BEFREE A case control study was conducted on Brazilian children in different regions of the country with the aim of investigating the role of MTHFR C677T and A1298C polymorphisms as risk factors in the development of acute myeloid leukemia (AML). 17071478

2006

dbSNP: rs1217691063
rs1217691063
0.080 GeneticVariation BEFREE In this study we describe the genotyping of the MTHFR C677T polymorphism by melting curve analysis with the LightCycler in a case-controlled study of patients with acute lymphocytic leukemia (ALL), myelogenous leukemia (AML), and chronic myelogenous leukemia (CML), and assess the effect of this common polymorphism on the leukemia risk in adult patients in Turkey. 15068389

2003