| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
T | 0.700 | GeneticVariation | CLINVAR | Prospective enterprise-level molecular genotyping of a cohort of cancer patients. | 25157968 | 2014 |
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|
T | 0.700 | GeneticVariation | CLINVAR | Detection of BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia on imatinib. | 23676790 | 2013 |
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|
T | 0.700 | GeneticVariation | CLINVAR | Ponatinib is a pan-BCR-ABL kinase inhibitor: MD simulations and SIE study. | 24236021 | 2013 |
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|
T | 0.700 | GeneticVariation | CLINVAR | Concomitant t(3;3)(q21;q26), trisomy 19, and E255V mutation associated with imatinib mesylate resistance in chronic myelogenous leukemia. | 19264234 | 2009 |
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|
T | 0.700 | GeneticVariation | CLINVAR | Conformational disturbance in Abl kinase upon mutation and deregulation. | 19164531 | 2009 |
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|
T | 0.700 | GeneticVariation | CLINVAR | High incidence of BCR-ABL kinase domain mutations and absence of mutations of the PDGFR and KIT activation loops in CML patients with secondary resistance to imatinib. | 14745431 | 2004 |
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|
T | 0.700 | GeneticVariation | CLINVAR | Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. | 12623848 | 2003 |
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|
T | 0.700 | GeneticVariation | CLINVAR | BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: a prospective study. | 11853795 | 2002 |
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|
T | 0.700 | GeneticVariation | CLINVAR | Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. | 12399961 | 2002 |
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|
T | 0.700 | GeneticVariation | CLINVAR | Roots of clinical resistance to STI-571 cancer therapy. | 11569495 | 2001 |