| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
A | 0.700 | GeneticVariation | CLINVAR | Prospective enterprise-level molecular genotyping of a cohort of cancer patients. | 25157968 | 2014 |
|||
|
A | 0.700 | GeneticVariation | CLINVAR | Detection of BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia on imatinib. | 23676790 | 2013 |
|||
|
A | 0.700 | GeneticVariation | CLINVAR | Early detection and quantification of mutations in the tyrosine kinase domain of chimerical BCR-ABL1 gene combining high-resolution melting analysis and mutant-allele specific quantitative polymerase chain reaction. | 22870928 | 2013 |
|||
|
A | 0.700 | GeneticVariation | CLINVAR | The ABL switch control inhibitor DCC-2036 is active against the chronic myeloid leukemia mutant BCR-ABLT315I and exhibits a narrow resistance profile. | 21505103 | 2011 |
|||
|
A | 0.700 | GeneticVariation | CLINVAR | Use of direct sequencing for detection of mutations in the BCR-ABL kinase domain in Slovak patients with chronic myeloid leukemia. | 21895409 | 2011 |
|||
|
A | 0.700 | GeneticVariation | CLINVAR | Mutations in ABL kinase domain are associated with inferior progression-free survival. | 20367437 | 2010 |
|||
|
A | 0.700 | GeneticVariation | CLINVAR | Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. | 12623848 | 2003 |
|||
|
A | 0.700 | GeneticVariation | CLINVAR | High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. | 11964322 | 2002 |