Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913458
rs121913458
T 0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014

dbSNP: rs121913458
rs121913458
C 0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014

dbSNP: rs121913458
rs121913458
C 0.700 GeneticVariation CLINVAR This scenario of Q252H-associated TKI resistance with rapid BC transformation has not been previously documented in e19a2 BCR-ABL1 CML. 24109527

2013

dbSNP: rs121913458
rs121913458
C 0.700 GeneticVariation CLINVAR Mutations in ABL kinase domain are associated with inferior progression-free survival. 20367437

2010

dbSNP: rs121913458
rs121913458
C 0.700 GeneticVariation CLINVAR Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML. 15256422

2004

dbSNP: rs121913458
rs121913458
T 0.700 GeneticVariation CLINVAR Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML. 15256422

2004

dbSNP: rs121913458
rs121913458
C 0.700 GeneticVariation CLINVAR Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. 12623848

2003

dbSNP: rs121913458
rs121913458
T 0.700 GeneticVariation CLINVAR Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. 12623848

2003

dbSNP: rs121913458
rs121913458
C 0.700 GeneticVariation CLINVAR Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. 12399961

2002