DisGeNET - a database of gene-disease associations

Myeloid Leukemia, Chronic, C0023473

Variant: rs121913461 ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs121913461

ABL1

0.700

GeneticVariation

CLINVAR

BCR-ABL kinase domain mutations, including 2 novel mutations in imatinib resistant Malaysian chronic myeloid leukemia patients-Frequency and clinical outcome.

24456693

2014

dbSNP:

rs121913461

ABL1

0.700

GeneticVariation

CLINVAR

Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

25157968

2014

dbSNP:

rs121913461

ABL1

0.700

GeneticVariation

CLINVAR

Detection of BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia on imatinib.

23676790

2013

dbSNP:

rs121913461

ABL1

0.700

GeneticVariation

CLINVAR

Use of direct sequencing for detection of mutations in the BCR-ABL kinase domain in Slovak patients with chronic myeloid leukemia.

21895409

2011

dbSNP:

rs121913461

ABL1

0.700

GeneticVariation

CLINVAR

Characteristics of BCR-ABL kinase domain point mutations in Chinese imatinib-resistant chronic myeloid leukemia patients.

20697894

2011

dbSNP:

rs121913461

ABL1

0.700

GeneticVariation

CLINVAR

The ABL switch control inhibitor DCC-2036 is active against the chronic myeloid leukemia mutant BCR-ABLT315I and exhibits a narrow resistance profile.

21505103

2011

dbSNP:

rs121913461

ABL1

0.700

GeneticVariation

CLINVAR

BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet.

21562040

2011

dbSNP:

rs121913461

ABL1

0.700

GeneticVariation

CLINVAR

Mutations in ABL kinase domain are associated with inferior progression-free survival.

20367437

2010

dbSNP:

rs121913461

ABL1

0.700

GeneticVariation

CLINVAR

High-resolution melting analysis for a reliable and two-step scanning of mutations in the tyrosine kinase domain of the chimerical bcr-abl gene.

19466505

2009

dbSNP:

rs121913461

ABL1

0.700

GeneticVariation

CLINVAR

Impact of baseline BCR-ABL mutations on response to nilotinib in patients with chronic myeloid leukemia in chronic phase.

19652056

2009

dbSNP:

rs121913461

ABL1

0.700

GeneticVariation

CLINVAR

Evidence of ABL-kinase domain mutations in highly purified primitive stem cell populations of patients with chronic myelogenous leukemia.

15381060

2004

dbSNP:

rs121913461

ABL1

0.700

GeneticVariation

CLINVAR

Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML.

15256422

2004

dbSNP:

rs121913461

ABL1

0.700

GeneticVariation

CLINVAR

High incidence of BCR-ABL kinase domain mutations and absence of mutations of the PDGFR and KIT activation loops in CML patients with secondary resistance to imatinib.

14745431

2004

dbSNP:

rs121913461

ABL1

0.700

GeneticVariation

CLINVAR

Inhibition of wild-type and mutant Bcr-Abl by pyrido-pyrimidine-type small molecule kinase inhibitors.

14559829

2003

dbSNP:

rs121913461

ABL1

0.700

GeneticVariation

CLINVAR

Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy.

12399961

2002

dbSNP:

rs121913461

ABL1

0.700

GeneticVariation

CLINVAR

High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance.

11964322

2002