Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs28934576
rs28934576
0.010 GeneticVariation BEFREE One patient had no p53 mutation in his leukemic cells during chronic phase of ATL, but had a homozygous point mutation at codon 273 (Arg to His) when he progressed to acute ATL. 1730092

1992

dbSNP: rs587781386
rs587781386
0.010 GeneticVariation BEFREE Double transversion mutations comprising of a missense mutation at codon 167 (Gln to His) in exon 5 and a nonsense mutation at codon 183 (Ser to stop codon) in exon 5 were detected in one DLBL that had apparently transformed from follicular lymphoma and in one advanced adult T-cell lymphoma (ATL). 17609875

2007

dbSNP: rs764562217
rs764562217
0.010 GeneticVariation BEFREE Double transversion mutations comprising of a missense mutation at codon 167 (Gln to His) in exon 5 and a nonsense mutation at codon 183 (Ser to stop codon) in exon 5 were detected in one DLBL that had apparently transformed from follicular lymphoma and in one advanced adult T-cell lymphoma (ATL). 17609875

2007

dbSNP: rs12979860
rs12979860
0.010 GeneticVariation BEFREE In an attempt to examine this hypothesis, we assessed the association of the rs12979860 genotypes with HTLV-1 PvL levels and clinical status in 112 unrelated Brazilian subjects (81 HTLV-1 asymptomatic carriers, 24 individuals with HAM/TSP and 7 with Adult T cell Leukemia/Lymphoma (ATLL)). 23259930

2012

dbSNP: rs759834538
rs759834538
0.010 GeneticVariation BEFREE Transforming activity was further demonstrated by the ability of the FBXW7 D510E mutant to provide IL-2-independent growth of Tax-immortalized human T cells and increase the tumor formation in a xenograft mouse model of ATL. 27247421

2016

dbSNP: rs72963007
rs72963007
0.010 GeneticVariation BEFREE Strikingly, 9 of the 14 patients showed the same variation (SNP rs72963007), whose frequency in ATLL patients was significantly higher than that of an ethnically matched control population (13% vs. 5%). 28881727

2017

dbSNP: rs1800682
rs1800682
0.010 GeneticVariation BEFREE We have previously shown that an IFN-responsive <i>FAS</i> promoter polymorphism in a STAT1 binding site (rs1800682) is associated to ATL susceptibility and survival. 29721391

2018

dbSNP: rs1157200929
rs1157200929
0.010 GeneticVariation BEFREE The most significantly enriched variants, causing p.Lys469Ter in a splice variant of POLK and p.Pro588His in PRKCB, are intriguing candidates as Polk deficient mice display a spontaneous mutator phenotype, whereas PRKCB was recently shown to be somatically mutated in 33% of another peripheral T-cell lymphoma, adult T-cell lymphoma. 30097855

2019

dbSNP: rs35631544
rs35631544
0.010 GeneticVariation BEFREE The most significantly enriched variants, causing p.Lys469Ter in a splice variant of POLK and p.Pro588His in PRKCB, are intriguing candidates as Polk deficient mice display a spontaneous mutator phenotype, whereas PRKCB was recently shown to be somatically mutated in 33% of another peripheral T-cell lymphoma, adult T-cell lymphoma. 30097855

2019

dbSNP: rs572432356
rs572432356
0.010 GeneticVariation BEFREE The most significantly enriched variants, causing p.Lys469Ter in a splice variant of POLK and p.Pro588His in PRKCB, are intriguing candidates as Polk deficient mice display a spontaneous mutator phenotype, whereas PRKCB was recently shown to be somatically mutated in 33% of another peripheral T-cell lymphoma, adult T-cell lymphoma. 30097855

2019

dbSNP: rs752626029
rs752626029
0.010 GeneticVariation BEFREE The most significantly enriched variants, causing p.Lys469Ter in a splice variant of POLK and p.Pro588His in PRKCB, are intriguing candidates as Polk deficient mice display a spontaneous mutator phenotype, whereas PRKCB was recently shown to be somatically mutated in 33% of another peripheral T-cell lymphoma, adult T-cell lymphoma. 30097855

2019