rs1157200929
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significantly enriched variants, causing p.Lys469Ter in a splice variant of POLK and p.Pro588His in PRKCB, are intriguing candidates as Polk deficient mice display a spontaneous mutator phenotype, whereas PRKCB was recently shown to be somatically mutated in 33% of another peripheral T-cell lymphoma, adult T-cell lymphoma.
|
30097855 |
2019 |
rs12979860
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In an attempt to examine this hypothesis, we assessed the association of the rs12979860 genotypes with HTLV-1 PvL levels and clinical status in 112 unrelated Brazilian subjects (81 HTLV-1 asymptomatic carriers, 24 individuals with HAM/TSP and 7 with Adult T cell Leukemia/Lymphoma (ATLL)).
|
23259930 |
2012 |
rs1800682
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have previously shown that an IFN-responsive <i>FAS</i> promoter polymorphism in a STAT1 binding site (rs1800682) is associated to ATL susceptibility and survival.
|
29721391 |
2018 |
rs28934576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One patient had no p53 mutation in his leukemic cells during chronic phase of ATL, but had a homozygous point mutation at codon 273 (Arg to His) when he progressed to acute ATL.
|
1730092 |
1992 |
rs35631544
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significantly enriched variants, causing p.Lys469Ter in a splice variant of POLK and p.Pro588His in PRKCB, are intriguing candidates as Polk deficient mice display a spontaneous mutator phenotype, whereas PRKCB was recently shown to be somatically mutated in 33% of another peripheral T-cell lymphoma, adult T-cell lymphoma.
|
30097855 |
2019 |
rs572432356
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significantly enriched variants, causing p.Lys469Ter in a splice variant of POLK and p.Pro588His in PRKCB, are intriguing candidates as Polk deficient mice display a spontaneous mutator phenotype, whereas PRKCB was recently shown to be somatically mutated in 33% of another peripheral T-cell lymphoma, adult T-cell lymphoma.
|
30097855 |
2019 |
rs587781386
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Double transversion mutations comprising of a missense mutation at codon 167 (Gln to His) in exon 5 and a nonsense mutation at codon 183 (Ser to stop codon) in exon 5 were detected in one DLBL that had apparently transformed from follicular lymphoma and in one advanced adult T-cell lymphoma (ATL).
|
17609875 |
2007 |
rs72963007
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Strikingly, 9 of the 14 patients showed the same variation (SNP rs72963007), whose frequency in ATLL patients was significantly higher than that of an ethnically matched control population (13% vs. 5%).
|
28881727 |
2017 |
rs752626029
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significantly enriched variants, causing p.Lys469Ter in a splice variant of POLK and p.Pro588His in PRKCB, are intriguing candidates as Polk deficient mice display a spontaneous mutator phenotype, whereas PRKCB was recently shown to be somatically mutated in 33% of another peripheral T-cell lymphoma, adult T-cell lymphoma.
|
30097855 |
2019 |
rs759834538
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Transforming activity was further demonstrated by the ability of the FBXW7 D510E mutant to provide IL-2-independent growth of Tax-immortalized human T cells and increase the tumor formation in a xenograft mouse model of ATL.
|
27247421 |
2016 |
rs764562217
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Double transversion mutations comprising of a missense mutation at codon 167 (Gln to His) in exon 5 and a nonsense mutation at codon 183 (Ser to stop codon) in exon 5 were detected in one DLBL that had apparently transformed from follicular lymphoma and in one advanced adult T-cell lymphoma (ATL).
|
17609875 |
2007 |