|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Recent large-scale clinical studies revealed a strong association between the NUDT15 p.Arg139Cys (NUDT15<sup>R139C</sup>) polymorphism and severe thiopurine-induced leukocytopenia.
|
31645647 |
2020 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our results indicate that careful monitoring of leukopenia and dose adjustment are necessary throughout treatment in IBD patients heterozygous for the NUDT15 R139C.
|
31045285 |
2019 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A significantly higher thiopurine-induced leukopenia risk was found for TPMT (OR 3.9, 95% [CI] 2.5-6.1) and for NUDT15 R139C (OR 6.9, 95% CI 5.2-9.1), G52A (OR 3.2, 95% CI 1.3-7.9) and 36_37ins/delGGAGTC variant carriers (OR 5.6, 95% CI 2.8-11.4).
|
31342537 |
2019 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We confirmed the association of NUDT15 p.Arg139Cys with leukopenia and alopecia (p = 2.20E-63, 1.32E-69, OR = 6.59, 12.1, respectively), and found a novel association with digestive symptoms (p = 6.39E-04, OR = 1.89).
|
29923122 |
2018 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
NUDT15 R139C Variants Increase the Risk of Azathioprine-Induced Leukopenia in Chinese Autoimmune Patients.
|
29867468 |
2018 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Results of meta-regression analysis showed that incidence of leukopenia (relative DOR: 0.96; 95%CI: 0.93-1.00, p = 0.037) and leukopenia onset (late vs early leukopenia, relative DOR: 0.41, 95% CI 0.20-0.85, p = 0.0189) significantly influenced diagnostic accuracy of rs116855232.
|
30048756 |
2018 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
CYP2D6 rs1135840 and NUDT15 rs116855232 increased the risks of hepatotoxicity and leukopenia with an odds ratio of 2.52 and 4.97, respectively.
|
29071720 |
2018 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The results of this meta-analysis confirm that NUDT15 c.415C>T may be an important predictor of thiopurine-induced leukocytopenia in Asians.
|
28470355 |
2018 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
NUDT15 intermediate activity variant, that is, heterozygous rs116855232 or rs186364861 variant, and the ABCC4 rs3765534 variant showed leukopenia more frequently than either variant alone.
|
28418010 |
2018 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
We confirmed the association of NUDT15 p.Arg139Cys with leukopenia and alopecia (p = 2.20E-63, 1.32E-69, OR = 6.59, 12.1, respectively), and found a novel association with digestive symptoms (p = 6.39E-04, OR = 1.89).
|
29923122 |
2018 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In this report, we first provide detailed clinical and laboratory characteristics of AZA-induced leukopenia in a patient with SS with a mutant NUDT15 R139C genotype (TT allele) and normal TPMT activity.
|
29702976 |
2018 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A genome-wide association approach to identify Asian-specific pharmacogenetic markers in Korean patients with Crohn's disease revealed that a non-synonymous single nucelotide polymorphism in nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) which causes p.Arg139Cys was strongly associated with thiopurine-induced early leukopenia.
|
29192347 |
2018 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
NUDT15 rs116855232 variants were strongly associated with a higher cumulative incidence of neutropenia (p < 0.01), and a lower median dose of tolerated MP throughout maintenance treatment (p < 0.01).
|
28882023 |
2018 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
NUDT15 variant (rs116855232) has been recently identified as a novel polymorphism related with thiopurine-induced leucopenia in inflammatory bowel disease and ALL.
|
28963908 |
2017 |
|
rs116855232
|
|
C |
0.800 |
GeneticVariation |
GWASCAT |
A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD.
|
27558924 |
2017 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Variant allele of rs116855232 contributes 7.86-fold (P < 0.00001, 95% CI: 6.13-10.08) higher risk to develop leucopenia with high specificity (91.74%) and sensitivity (43.19%), and lower thiopurines intolerance dose (P < 0.00001).
|
28088792 |
2017 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Therefore, the NUDT15 p.R139C variant is common and strongly associated with AZA-induced early leukopenia and severe alopecia in Korean patients with various neurological diseases.
|
28566182 |
2017 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Combined detection of the 3 variants could increase the predictive sensitivity of thiopurine-induced leukopenia and help to distinguish early leukopenia in heterozygote of c.415C>T in Chinese patients with IBD.
|
28570428 |
2017 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Recently, few studies reported on an inherited nucleoside diphosphate-linked moiety X motif 15 (NUDT15) c.415C>T low-function variant that is associated with decreased thiopurine metabolism and leukopenia in childhood acute lymphoblastic leukemia (ALL) and other diseases.
|
27577869 |
2017 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Three non-synonymous SNPs, which we previously reported association with thiopurine-induced leukopenia, NUDT15 (p.Arg139Cys), SUCLA2 (p.Ser199Thr), and TPMT *3C were selected for epistasis analysis with the XDH variants.
|
26863601 |
2016 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These results suggest that NUDT15 R139C-related thiopurine-induced leukocytopenia is mediated by a 6-TGN-independent mechanism.
|
26590936 |
2016 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In addition to the mutations of TPMT gene, the NUDT15 c.415C>T variant was recently identified to have a strong association with thiopurine-induced early leukopenia.
|
26735160 |
2016 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
NUDT15 R139C was strongly associated with the incidence of leukopenia (70.2% mutation vs. 12.8% wild type; P=8.61×10<sup>-19</sup> ; odds ratio, 10.80; 95% CI, 5.89-19.83).
|
27604507 |
2016 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
NUDT15 c.415C>T may be another predictor of AZA-induced leukocytopenia.
|
27381176 |
2016 |
|
rs116855232
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We also verified the previously reported association of R139C with early leukopenia in a different East Asian population.
|
26076924 |
2016 |