|
rs10020432
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, we identified two SNPs in AFP intron 7 and 3'UTR, rs2298839 and rs10020432, which are associated with increased risk of cirrhosis.
|
19968979 |
2010 |
|
rs10053538
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study simultaneously examined PD-1 and TIM-3 expression in liver tissues and PD1 and TIM3 polymorphisms and analyzed their correlations in 171 patients with HBV-related HCC and 34 patients with HBV-related cirrhosis.PD-1 and TIM-3 expression in liver tissues were examined by immunohistochemistry and the genotypes of PD1 rs10204525 and TIM3 rs10053538 polymorphisms were determined using genomic DNA extracted from peripheral blood as template.Both PD-1 and TIM-3 expressions in liver infiltrating lymphocytes of HCC tumor tissues were significantly higher than those in tumor adjacent tissues or cirrhotic tissues.
|
28033288 |
2016 |
|
rs1012068
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, DEPDC5 rs1012068 was independently associated with cirrhosis (n = 300; P = 0.049).
|
26517016 |
2016 |
|
rs1012068
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Also, our results revealed that GT for SNP rs1012068 (OR =1.715; 95% CI 1.132-2.597; p = 0.0104) and CT for SNP rs5998152 (OR = 1.932; 9</span>5% CI 1.276-2.925; p = 0.0017) showed significant association with development of cirrhosis compared with the GG and CC genotypes, respectively.
|
25551790 |
2014 |
|
rs10146249
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found three differentially distributed SNPs (rs8021276, rs7158733, and rs10146249) via the screening analysis; however, only rs8021276 polymorphism was further identified to modify the risk of LC.
|
29937988 |
2018 |
|
rs10204525
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study simultaneously examined PD-1 and TIM-3 expression in liver tissues and PD1 and TIM3 polymorphisms and analyzed their correlations in 171 patients with HBV-related HCC and 34 patients with HBV-related cirrhosis.PD-1 and TIM-3 expression in liver tissues were examined by immunohistochemistry and the genotypes of PD1 rs10204525 and TIM3 rs10053538 polymorphisms were determined using genomic DNA extracted from peripheral blood as template.Both PD-1 and TIM-3 expressions in liver infiltrating lymphocytes of HCC tumor tissues were significantly higher than those in tumor adjacent tissues or cirrhotic tissues.
|
28033288 |
2016 |
|
rs1041740
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These data suggest a complex role of SOD1 in different processes leading to complications of liver cirrhosis. rs1041740 might be associated with the development of ascites and possibly plays a role in SBP once ascites has developed.
|
28403123 |
2017 |
|
rs10433937
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that SERPINA1 Pi*S variant conferred an increased risk of developing liver fibrosis, while SERPINA1 Pi*Z and HSD17B13 rs10433937 were not associated with liver fibrosis or cirrhosis of different aetiology.
|
31517326 |
2019 |
|
rs1049305
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that the rs1049305 (C/G, UTR3) AQP1 polymorphism could be involved in the genetic susceptibility to develop water retention in patients with liver cirrhosis.
|
21793635 |
2011 |
|
rs1054690270
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The S267F variant on the NTCP gene is inversely associated with the chronicity of HBV infection, progression to cirrhosis and hepatocellular carcinoma in East Asian populations.
|
28635613 |
2018 |
|
rs1056836
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, high risk for liver cirrhosis-positive clinical status was exhibited in HCC patients with rs1056836 CG and GG genotypes as compared with CC homozygotes.
|
25796598 |
2015 |
|
rs1059122
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression analyses revealed that the risk of liver cirrhosis was significantly higher in subjects with the G/A-G/G genotype of rs3017895 than those with A/A genotype under the dominant model and log additive model, and the T/A-A/A genotype of rs1059122 was positively associated with higher liver cirrhosis than T/T genotype based on dominant model respectively.
|
30604588 |
2019 |
|
rs10932029
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs10932029 genotype "TC" might be an LC-protective factor for HBV genotype C infection.
|
30600290 |
2018 |
|
rs10945859
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among these SNPs, CT genotype of rs10945859 was found to have a significant association towards the clinical progression of chronic HCV infection to cirrhosis alone (OR = 1.850; 95% C. I.
|
27740515 |
2017 |
|
rs11003123
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MBL2 rs11003123 polymorphism may be a marker for the risk of HCC occurrence in patients with HBV-related cirrhosis in the Chinese population.
|
27298104 |
2016 |
|
rs1127354
|
|
|
0.010 |
GeneticVariation |
BEFREE |
69 consecutive HCV-1 patients (mean age 57 years) with F3-F4 who received PR and TVR were genotyped for ITPA polymorphisms rs1127354 and rs7270101.
|
24760000 |
2014 |
|
rs1140409
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We recently identified a missense single nucleotide polymorphism (SNP) in DDX5 (rs1140409, p.S480A) that enhances the risk of developing cirrhosis.
|
20022962 |
2010 |
|
rs11554495
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In summary, the cytokeratin 8 mutation G61C, which has been found to be associated with cryptogenic liver cirrhosis, was also found in the present patient population.
|
16911694 |
2006 |
|
rs11554495
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Of the 349 blood bank control samples, only one contained the Tyr-53 --> His and one the Gly-61 --> Cys K8 mutations (P < 0.004 when comparing cirrhosis versus control groups).
|
12724528 |
2003 |
|
rs1161457931
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PCSK7 variant rs236918 is a risk factor for cirrhosis in HH patients homozygous for the HFE C282Y mutation.
|
24556216 |
2014 |
|
rs11614913
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In addition, we found that rs2292832 and rs11614913 were associated with risk of HBV infection, viral clearance and cirrhosis+HCC, whereas rs2910164 was associated with proneness to HBV infection, and ability to clear the virus.
|
28685993 |
2017 |
|
rs11614913
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The MIR196A2 rs11614913 C > T polymorphism may contribute to an increased risk of HPS in liver cirrhosis patients.
|
27509319 |
2017 |
|
rs11977021
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we genotyped two potentially functional single nucleotide polymorphisms (SNPs) in the visfatin promoter region, -1535C>T (rs61330082) and -3187G>A (rs11977021), in 120 HBV-related chronic hepatitis B (CHB) patients, 140 HBV-related liver cirrhosis (HBV-LC) patients, 243 HBV-related hepatocellular carcinoma (HBV-HCC) patients, and 224 asymptomatic HBV carriers.
|
27792999 |
2016 |
|
rs1201810520
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Z variant (Glu342Lys) of α(1)-antitrypsin (AT) polymerizes and accumulates in the hepatocyte endoplasmic reticulum (ER) predisposing to neonatal hepatitis and liver cirrhosis.
|
22425623 |
2012 |
|
rs12075
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Specifically, patients with the <i>DARC</i> rs12075 AG/GG genotype had a lower risk of liver fibrosis progression and development of cirrhosis.
|
30970632 |
2019 |