|
rs587782329
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Lung tumors of 50 uranium miners in Germany were screened by restriction fragment length analysis for the putative hotspot mutation at codon 249 (Arg-->Met) previously detected in a significant fraction of miners from the Colorado Plateau, USA.
|
9067550 |
1997 |
|
rs1052559
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Functional polymorphisms in XPD (Asp312Asn, rs1799793 and Lys751Gln, rs1052559), a protein required for nucleotide excision repair and with roles in p53-mediated apoptosis, were modestly associated with G:C-->T:A mutations in TP53 in lung tumors [Asp/Asn312 + Asn/Asn312 and/or Lys/Gln751 + Gln/Gln751 versus Asp/Asp312 + Lys/Lys751; odds ratio (OR) 2.73, 95% confidence interval (CI) 0.98-7.61], consistent with the role of this protein in repair of bulky carcinogen-DNA adducts.
|
15564288 |
2005 |
|
rs13181
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Functional polymorphisms in XPD (Asp312Asn, rs1799793 and Lys751Gln, rs1052559), a protein required for nucleotide excision repair and with roles in p53-mediated apoptosis, were modestly associated with G:C-->T:A mutations in TP53 in lung tumors [Asp/Asn312 + Asn/Asn312 and/or Lys/Gln751 + Gln/Gln751 versus Asp/Asp312 + Lys/Lys751; odds ratio (OR) 2.73, 95% confidence interval (CI) 0.98-7.61], consistent with the role of this protein in repair of bulky carcinogen-DNA adducts.
|
15564288 |
2005 |
|
rs1799793
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Functional polymorphisms in XPD (Asp312Asn, rs1799793 and Lys751Gln, rs1052559), a protein required for nucleotide excision repair and with roles in p53-mediated apoptosis, were modestly associated with G:C-->T:A mutations in TP53 in lung tumors [Asp/Asn312 + Asn/Asn312 and/or Lys/Gln751 + Gln/Gln751 versus Asp/Asp312 + Lys/Lys751; odds ratio (OR) 2.73, 95% confidence interval (CI) 0.98-7.61], consistent with the role of this protein in repair of bulky carcinogen-DNA adducts.
|
15564288 |
2005 |
|
rs1174029586
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mutant Ki-ras(G12C) expression was sufficient for initial lung tumor transformation, required for maintenance of tumor phenotype, and induced transformation of lung epithelial cells by the activation of multiple effector pathways.
|
16051643 |
2005 |
|
rs1242640031
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mutant Ki-ras(G12C) expression was sufficient for initial lung tumor transformation, required for maintenance of tumor phenotype, and induced transformation of lung epithelial cells by the activation of multiple effector pathways.
|
16051643 |
2005 |
|
rs947996134
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mutant Ki-ras(G12C) expression was sufficient for initial lung tumor transformation, required for maintenance of tumor phenotype, and induced transformation of lung epithelial cells by the activation of multiple effector pathways.
|
16051643 |
2005 |
|
rs121434569
|
|
|
0.060 |
GeneticVariation |
BEFREE |
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib.
|
18093943 |
2007 |
|
rs121913529
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Importantly, the combined inactivation of both MYC and K-ras(G12D) resulted more frequently in complete lung tumor regression.
|
18461184 |
2008 |
|
rs121434569
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Nevertheless, several lines of evidence indicate that the T790M mutation confers growth advantage to cancer cells, and it was shown that mice expressing tetracycline-inducible EGFR transgenes harboring the T790M mutation develop lung tumors.
|
19096299 |
2009 |
|
rs762846821
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Conversely, in lung tumour cell lines expressing Kras(G12D) and lacking p53, p53 restoration led to NF-kappaB inhibition.
|
19847165 |
2009 |
|
rs1458974438
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In mice, Lkb1 deletion and activation of Kras(G12D) results in lung tumors with a high penetrance of lymph node and distant metastases.
|
20541700 |
2010 |
|
rs752021744
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In mice, Lkb1 deletion and activation of Kras(G12D) results in lung tumors with a high penetrance of lymph node and distant metastases.
|
20541700 |
2010 |
|
rs121913529
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Moreover, Klf5 is not required for lung tumor formation in an inducible oncogenic K-Ras(G12D) mouse model of lung tumorigenesis, and non-small cell lung cancer patients expressing high levels of KLF5 (21/258) have a significantly better disease-specific survival than those with intermediate to no KLF5 expression.
|
20639455 |
2010 |
|
rs199976573
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, Klf5 is not required for lung tumor formation in an inducible oncogenic K-Ras(G12D) mouse model of lung tumorigenesis, and non-small cell lung cancer patients expressing high levels of KLF5 (21/258) have a significantly better disease-specific survival than those with intermediate to no KLF5 expression.
|
20639455 |
2010 |
|
rs16906252
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A allele was selectively methylated in primary lung tumors and cell lines heterozygous for rs16906252.
|
21355081 |
2011 |
|
rs12072037
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs12072037 modulates MFSD2A promoter activity and thus might affect MFSD2A levels in normal lung and in lung tumors, representing a candidate ethnically specific genetic factor underlying the association between the MYCL1 locus and lung cancer patients' survival.
|
21736709 |
2011 |
|
rs121913529
|
|
|
0.080 |
GeneticVariation |
BEFREE |
However, a more rigorous test of the requirement for Notch signaling in lung oncogenesis, crossing the LSL-KRAS(G12D) mouse model with a transgenic with a similarly inducible global dominant-negative suppressor of Notch activity, LSL-DNMAML (dominant-negative mastermind-like), reveals no evidence of Notch pathway requirement for lung tumor initiation or growth in vivo.
|
21994468 |
2011 |
|
rs775514340
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, a more rigorous test of the requirement for Notch signaling in lung oncogenesis, crossing the LSL-KRAS(G12D) mouse model with a transgenic with a similarly inducible global dominant-negative suppressor of Notch activity, LSL-DNMAML (dominant-negative mastermind-like), reveals no evidence of Notch pathway requirement for lung tumor initiation or growth in vivo.
|
21994468 |
2011 |
|
rs1057519847
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Using specific and sensitive IHC assays, we analyzed the expression of anaplastic lymphoma kinase (ALK), EGFR L858R, and EGFR E746-A750del mutations in a subset of lung tumors, including those expressing ROS1.
|
22661537 |
2012 |
|
rs1057519848
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Using specific and sensitive IHC assays, we analyzed the expression of anaplastic lymphoma kinase (ALK), EGFR L858R, and EGFR E746-A750del mutations in a subset of lung tumors, including those expressing ROS1.
|
22661537 |
2012 |
|
rs121434568
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Using specific and sensitive IHC assays, we analyzed the expression of anaplastic lymphoma kinase (ALK), EGFR L858R, and EGFR E746-A750del mutations in a subset of lung tumors, including those expressing ROS1.
|
22661537 |
2012 |
|
rs113488022
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We combined (L597V)Braf with (G12D)Kras and found that (L597V)Braf modified (G12D)Kras oncogenesis such that fibroblast transformation and lung tumor development were more reminiscent of that driven by the high-activity (V600E)Braf mutant.
|
22892241 |
2012 |
|
rs121913377
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We combined (L597V)Braf with (G12D)Kras and found that (L597V)Braf modified (G12D)Kras oncogenesis such that fibroblast transformation and lung tumor development were more reminiscent of that driven by the high-activity (V600E)Braf mutant.
|
22892241 |
2012 |
|
rs1018379423
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We combined (L597V)Braf with (G12D)Kras and found that (L597V)Braf modified (G12D)Kras oncogenesis such that fibroblast transformation and lung tumor development were more reminiscent of that driven by the high-activity (V600E)Braf mutant.
|
22892241 |
2012 |