Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2476601
rs2476601
0.030 GeneticVariation BEFREE To replicate a single nucleotide polymorphism (SNP) of known genes for lupus (IRF5 rs10488631, PTPN22 rs2476601, BLK rs2736340 and TNFAIP3 rs5029939) and other autoimmune diseases (CD28 rs1980422, IL2RA rs2104286 and KIF5A rs1678542) on a newly studied Egyptian cohort to investigate the genetic disparity with different studied ethnic groups in relation to lupus susceptibility. 26092158

2015

dbSNP: rs2476601
rs2476601
0.030 GeneticVariation BEFREE The protein tyrosine phosphatase LYP, a key regulator of TCR signaling, presents a single nucleotide polymorphism, C1858T, associated with several autoimmune diseases such as type I diabetes, rheumatoid arthritis, and lupus. 23359562

2013

dbSNP: rs2476601
rs2476601
0.030 GeneticVariation BEFREE The PTPN22 C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon-alpha activity and low tumor necrosis factor alpha levels in patients with lupus. 18759295

2008

dbSNP: rs1143679
rs1143679
0.020 GeneticVariation BEFREE For the first time, we have shown that the polymorphisms located in the <i>STAT4</i> (rs7574865), but not in the <i>ITGAM</i> (rs1143679) nor the <i>TNXB</i> (rs1150754) genes, might be associated with the development of DLE within the Polish population. 28670251

2017

dbSNP: rs7574865
rs7574865
0.020 GeneticVariation BEFREE For the first time, we have shown that the polymorphisms located in the <i>STAT4</i> (rs7574865), but not in the <i>ITGAM</i> (rs1143679) nor the <i>TNXB</i> (rs1150754) genes, might be associated with the development of DLE within the Polish population. 28670251

2017

dbSNP: rs1143679
rs1143679
0.020 GeneticVariation BEFREE The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes. 22586164

2012

dbSNP: rs3813946
rs3813946
CR2
0.020 GeneticVariation BEFREE These data confirm the effects of rs3813946 on CR2 transcription, identifying the 5' UTR to be a novel regulatory element for the CR2 gene in which variation may alter gene function and modify the development of lupus. 22673213

2012

dbSNP: rs3813946
rs3813946
CR2
0.020 GeneticVariation BEFREE Single-nucleotide polymorphism 1 (rs3813946), located in the 5' untranslated region of the CR2 gene, altered transcriptional activity, suggesting a potential mechanism by which CR2 could contribute to the development of lupus. 17360460

2007

dbSNP: rs7574865
rs7574865
0.020 GeneticVariation BEFREE The haplotype marked by rs7574865 was strongly associated with lupus, being present on 31% of chromosomes of case patients and 22% of those of controls (P=1.87x10(-9); odds ratio for having the risk allele in chromosomes of patients vs. those of controls, 1.55). 17804842

2007

dbSNP: rs1800625
rs1800625
0.010 GeneticVariation BEFREE The rs1800625 SNP may be associated with the development of diabetic retinopathy, cancer, and lupus but may be protective against cardiovascular risk. 30863465

2019

dbSNP: rs3810936
rs3810936
0.010 GeneticVariation BEFREE Our findings indicate that gene polymorphisms (rs3810936, rs7848647) of TL1A might correlate with lupus. 31081141

2019

dbSNP: rs7848647
rs7848647
0.010 GeneticVariation BEFREE Our findings indicate that gene polymorphisms (rs3810936, rs7848647) of TL1A might correlate with lupus. 31081141

2019

dbSNP: rs1050501
rs1050501
0.010 GeneticVariation BEFREE The Lupus-Associated Fcγ Receptor IIb-I232T Polymorphism Results in Impairment in the Negative Selection of Low-Affinity Germinal Center B Cells Via c-Abl in Mice. 29774664

2018

dbSNP: rs1130864
rs1130864
CRP
0.010 GeneticVariation BEFREE Four of the polymorphisms showed differences between patients and controls. rs3093061 polymorphism was associated with a lower risk of developing lupus principally in the codominant 2 (OR = 0.219, 95% CI 0.108-0.785, P = 0.015) model. rs1130864 was associated with decreased risk mainly under codominant 1 (OR = 0.288, 95% CI 0.143-0.581, P = 0.001) model. rs1205 was associated under the over-dominant model (OR = 0.504, 95% CI 0.270-0.942, P = 0.032). 29556849

2018

dbSNP: rs11889341
rs11889341
0.010 GeneticVariation BEFREE Consistent with expression quantitative trait locus (eQTL) analysis, the l</span>upus risk allele of rs11889341 decreased the activity of this putative repressor. 29912393

2018

dbSNP: rs1205
rs1205
CRP
0.010 GeneticVariation BEFREE Four of the polymorphisms showed differences between patients and controls. rs3093061 polymorphism was associated with a lower risk of developing lupus principally in the codominant 2 (OR = 0.219, 95% CI 0.108-0.785, P = 0.015) model. rs1130864 was associated with decreased risk mainly under codominant 1 (OR = 0.288, 95% CI 0.143-0.581, P = 0.001) model. rs1205 was associated under the over-dominant model (OR = 0.504, 95% CI 0.270-0.942, P = 0.032). 29556849

2018

dbSNP: rs12583006
rs12583006
0.010 GeneticVariation BEFREE Moreover, the presence of the AA genotype of the rs12583006 BAFF gene variant increased susceptibility for both lupus and lupus related plaque formation (ORs [95%CI]: 2.8 [1.1-7.1], and 4.4 [1.3-15.4] in the codominant model, respectively). 29859654

2018

dbSNP: rs1518110
rs1518110
0.010 GeneticVariation BEFREE Meanwhile, significant difference in genotype frequency at rs1518110 and rs1518111 were found in patients with and without lupus headache (P=0.025, P=0.038, respectively). 29199038

2018

dbSNP: rs1518111
rs1518111
0.010 GeneticVariation BEFREE Meanwhile, significant difference in genotype frequency at rs1518110 and rs1518111 were found in patients with and without lupus headache (P=0.025, P=0.038, respectively). 29199038

2018

dbSNP: rs1616583
rs1616583
0.010 GeneticVariation BEFREE To clarify the potential involvement of two novel single-nucleotide polymorphisms (SNPs) located in the <i>TLR7</i> gene (rs1634318 and rs1616583) in a variety of immune-related conditions, we studied the variability of these loci in patients from a Polish population with SLE and DLE, as well as in immunocompromised patients who were affected by invasive aspergillosis (IA) and those who were not affected. 29599669

2018

dbSNP: rs2004640
rs2004640
0.010 GeneticVariation BEFREE Although we could not demonstrate susceptibility toward lupus in the presence of IRF5 rs2004640 (G/T) polymorphism, further exploration of the genetic variability of IRF5 may help uncover its pathogenic role in Indian SLE patients. 30168487

2018

dbSNP: rs3093061
rs3093061
CRP
0.010 GeneticVariation BEFREE Four of the polymorphisms showed differences between patients and controls. rs3093061 polymorphism was associated with a lower risk of developing lupus principally in the codominant 2 (OR = 0.219, 95% CI 0.108-0.785, P = 0.015) model. rs1130864 was associated with decreased risk mainly under codominant 1 (OR = 0.288, 95% CI 0.143-0.581, P = 0.001) model. rs1205 was associated under the over-dominant model (OR = 0.504, 95% CI 0.270-0.942, P = 0.032). 29556849

2018

dbSNP: rs1150754
rs1150754
0.010 GeneticVariation BEFREE For the first time, we have shown that the polymorphisms located in the <i>STAT4</i> (rs7574865), but not in the <i>ITGAM</i> (rs1143679) nor the <i>TNXB</i> (rs1150754) genes, might be associated with the development of DLE within the Polish population. 28670251

2017

dbSNP: rs1876453
rs1876453
CR2
0.010 GeneticVariation BEFREE These data suggest that rs1876453 in CR2 has long-range effects on gene regulation that decrease susceptibility to lupus. 25180293

2016

dbSNP: rs2275913
rs2275913
0.010 GeneticVariation BEFREE Interleukin-17A rs2275913, Interleukin-17F rs763780 and rs2397084 gene polymorphisms as possible risk factors in Juvenile lupus and lupus related nephritis. 26515887

2016