rs2476601
|
|
|
0.030 |
GeneticVariation |
BEFREE |
To replicate a single nucleotide polymorphism (SNP) of known genes for lupus (IRF5 rs10488631, PTPN22 rs2476601, BLK rs2736340 and TNFAIP3 rs5029939) and other autoimmune diseases (CD28 rs1980422, IL2RA rs2104286 and KIF5A rs1678542) on a newly studied Egyptian cohort to investigate the genetic disparity with different studied ethnic groups in relation to lupus susceptibility.
|
26092158 |
2015 |
rs2476601
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The protein tyrosine phosphatase LYP, a key regulator of TCR signaling, presents a single nucleotide polymorphism, C1858T, associated with several autoimmune diseases such as type I diabetes, rheumatoid arthritis, and lupus.
|
23359562 |
2013 |
rs2476601
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The PTPN22 C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon-alpha activity and low tumor necrosis factor alpha levels in patients with lupus.
|
18759295 |
2008 |
rs1143679
|
|
|
0.020 |
GeneticVariation |
BEFREE |
For the first time, we have shown that the polymorphisms located in the <i>STAT4</i> (rs7574865), but not in the <i>ITGAM</i> (rs1143679) nor the <i>TNXB</i> (rs1150754) genes, might be associated with the development of DLE within the Polish population.
|
28670251 |
2017 |
rs7574865
|
|
|
0.020 |
GeneticVariation |
BEFREE |
For the first time, we have shown that the polymorphisms located in the <i>STAT4</i> (rs7574865), but not in the <i>ITGAM</i> (rs1143679) nor the <i>TNXB</i> (rs1150754) genes, might be associated with the development of DLE within the Polish population.
|
28670251 |
2017 |
rs1143679
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes.
|
22586164 |
2012 |
rs3813946
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These data confirm the effects of rs3813946 on CR2 transcription, identifying the 5' UTR to be a novel regulatory element for the CR2 gene in which variation may alter gene function and modify the development of lupus.
|
22673213 |
2012 |
rs3813946
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Single-nucleotide polymorphism 1 (rs3813946), located in the 5' untranslated region of the CR2 gene, altered transcriptional activity, suggesting a potential mechanism by which CR2 could contribute to the development of lupus.
|
17360460 |
2007 |
rs7574865
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The haplotype marked by rs7574865 was strongly associated with lupus, being present on 31% of chromosomes of case patients and 22% of those of controls (P=1.87x10(-9); odds ratio for having the risk allele in chromosomes of patients vs. those of controls, 1.55).
|
17804842 |
2007 |
rs1800625
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1800625 SNP may be associated with the development of diabetic retinopathy, cancer, and lupus but may be protective against cardiovascular risk.
|
30863465 |
2019 |
rs3810936
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings indicate that gene polymorphisms (rs3810936, rs7848647) of TL1A might correlate with lupus.
|
31081141 |
2019 |
rs7848647
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings indicate that gene polymorphisms (rs3810936, rs7848647) of TL1A might correlate with lupus.
|
31081141 |
2019 |
rs1050501
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Lupus-Associated Fcγ Receptor IIb-I232T Polymorphism Results in Impairment in the Negative Selection of Low-Affinity Germinal Center B Cells Via c-Abl in Mice.
|
29774664 |
2018 |
rs1130864
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four of the polymorphisms showed differences between patients and controls. rs3093061 polymorphism was associated with a lower risk of developing lupus principally in the codominant 2 (OR = 0.219, 95% CI 0.108-0.785, P = 0.015) model. rs1130864 was associated with decreased risk mainly under codominant 1 (OR = 0.288, 95% CI 0.143-0.581, P = 0.001) model. rs1205 was associated under the over-dominant model (OR = 0.504, 95% CI 0.270-0.942, P = 0.032).
|
29556849 |
2018 |
rs11889341
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Consistent with expression quantitative trait locus (eQTL) analysis, the l</span>upus risk allele of rs11889341 decreased the activity of this putative repressor.
|
29912393 |
2018 |
rs1205
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four of the polymorphisms showed differences between patients and controls. rs3093061 polymorphism was associated with a lower risk of developing lupus principally in the codominant 2 (OR = 0.219, 95% CI 0.108-0.785, P = 0.015) model. rs1130864 was associated with decreased risk mainly under codominant 1 (OR = 0.288, 95% CI 0.143-0.581, P = 0.001) model. rs1205 was associated under the over-dominant model (OR = 0.504, 95% CI 0.270-0.942, P = 0.032).
|
29556849 |
2018 |
rs12583006
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the presence of the AA genotype of the rs12583006 BAFF gene variant increased susceptibility for both lupus and lupus related plaque formation (ORs [95%CI]: 2.8 [1.1-7.1], and 4.4 [1.3-15.4] in the codominant model, respectively).
|
29859654 |
2018 |
rs1518110
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, significant difference in genotype frequency at rs1518110 and rs1518111 were found in patients with and without lupus headache (P=0.025, P=0.038, respectively).
|
29199038 |
2018 |
rs1518111
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, significant difference in genotype frequency at rs1518110 and rs1518111 were found in patients with and without lupus headache (P=0.025, P=0.038, respectively).
|
29199038 |
2018 |
rs1616583
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To clarify the potential involvement of two novel single-nucleotide polymorphisms (SNPs) located in the <i>TLR7</i> gene (rs1634318 and rs1616583) in a variety of immune-related conditions, we studied the variability of these loci in patients from a Polish population with SLE and DLE, as well as in immunocompromised patients who were affected by invasive aspergillosis (IA) and those who were not affected.
|
29599669 |
2018 |
rs2004640
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although we could not demonstrate susceptibility toward lupus in the presence of IRF5 rs2004640 (G/T) polymorphism, further exploration of the genetic variability of IRF5 may help uncover its pathogenic role in Indian SLE patients.
|
30168487 |
2018 |
rs3093061
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four of the polymorphisms showed differences between patients and controls. rs3093061 polymorphism was associated with a lower risk of developing lupus principally in the codominant 2 (OR = 0.219, 95% CI 0.108-0.785, P = 0.015) model. rs1130864 was associated with decreased risk mainly under codominant 1 (OR = 0.288, 95% CI 0.143-0.581, P = 0.001) model. rs1205 was associated under the over-dominant model (OR = 0.504, 95% CI 0.270-0.942, P = 0.032).
|
29556849 |
2018 |
rs1150754
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the first time, we have shown that the polymorphisms located in the <i>STAT4</i> (rs7574865), but not in the <i>ITGAM</i> (rs1143679) nor the <i>TNXB</i> (rs1150754) genes, might be associated with the development of DLE within the Polish population.
|
28670251 |
2017 |
rs1876453
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These data suggest that rs1876453 in CR2 has long-range effects on gene regulation that decrease susceptibility to lupus.
|
25180293 |
2016 |
rs2275913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interleukin-17A rs2275913, Interleukin-17F rs763780 and rs2397084 gene polymorphisms as possible risk factors in Juvenile lupus and lupus related nephritis.
|
26515887 |
2016 |