|
rs2205960
|
|
|
0.880 |
GeneticVariation |
BEFREE |
In TNFSF4, rs2205960 was associated with SLE independently from the effect of rs844648 (P=6.26 x 10(-3)), but not vice versa (P=0.55).
|
19357697 |
2009 |
|
rs2205960
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Single-marker analysis validated the association of BLK rs2736340 (P=4.25×10(-6)) as well as TNFSF4 rs2205960 (P=2.82×10(-5)) and TNFAIP3 rs5029939 (P=1.92×10(-3)) with SLE susceptibility in Chinese.
|
21905002 |
2012 |
|
rs2205960
|
|
|
0.880 |
GeneticVariation |
BEFREE |
The SNPs of TNFSF4 were associated with renal involvement in lupus patients from the Chinese population (P values for rs2205960 and rs10489265 were 0.014 and 0.005 in additive model, resp.).
|
23936824 |
2013 |
|
rs2205960
|
|
|
0.880 |
GeneticVariation |
BEFREE |
The results of our meta-analysis suggest that the TNFSF4 rs2205960 polymorphism may confer susceptibility to SLE in different populations and that the TNFSF4 rs1234315 polymorphism is associated with susceptibility to SLE in Asians.
|
22850862 |
2013 |
|
rs2205960
|
|
|
0.880 |
GeneticVariation |
BEFREE |
The present study suggested that TNFSF4 rs1234315 and rs2205960 polymorphisms were associated with SLE susceptibility.
|
31299880 |
2019 |
|
rs2205960
|
|
|
0.880 |
GeneticVariation |
BEFREE |
The frequency of minor T allele of TNFSF4 rs2205960 was significant in Chinese and Indian patients with SLE, with P values of 0.05 (OR = 1.27, 95% CI: 1.00-1.61) and 0.004 (OR = 3.16, 95% CI: 1.41-7.05), respectively.
|
27519474 |
2016 |
|
rs2205960
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Known SLE and SSc TNFSF4 susceptibility variants (rs2205960, rs1234317, rs12039904, rs10912580, and rs844648) were genotyped in 1031 patients with SSc and 1014 controls of French white ancestry.
|
22422496 |
2012 |
|
rs2205960
|
|
|
0.880 |
GeneticVariation |
BEFREE |
A total of 21 comparative studies were included in this meta-analysis; meta-analysis showed an association between the minor allele of rs2205960 of TNFSF4 and SLE in all study subjects (odds ratio [OR]=1.356, 95% confidence interval [CI]=1.275-1.442, p<1.0×10(-9)).
|
22820624 |
2012 |
|
rs10798269
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Aside from the expected strong association between SLE and the HLA region on chromosome 6p21 and the previously confirmed non-HLA locus IRF5 on chromosome 7q32, we found evidence of association with replication (1.1 x 10(-7) < P(overall) < 1.6 x 10(-23); odds ratio = 0.82-1.62) in four regions: 16p11.2 (ITGAM), 11p15.5 (KIAA1542), 3p14.3 (PXK) and 1q25.1 (rs10798269).
|
18204446 |
2008 |
|
rs704840
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Significant association of m</span>inor G allele of rs704840</span> with SLE was also observed in Chinese (P = 0.03, OR = 1.26, 95% CI: 1.02-1.56).
|
27519474 |
2016 |
|
rs10489265
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The SNPs of TNFSF4 were associated with renal involvement in lupus patients from the Chinese population (P values for rs2205960 and rs10489265 were 0.014 and 0.005 in additive model, resp.).
|
23936824 |
2013 |
|
rs10489265
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Meta-analysis revealed an association between the minor alleles of rs1234315 and rs10489265 of TNFSF4 and SLE in Asians (OR=1.366, 95% CI=1.295-1.440, p<1.0×10(-9); OR=1.463, 95% CI=1.208-1.771, p=9.7×10(-5)).
|
22820624 |
2012 |
|
rs844648
|
|
|
0.720 |
GeneticVariation |
BEFREE |
No association was found between the rs844644 and rs844648 polymorphisms and SLE.
|
22850862 |
2013 |
|
rs844648
|
|
|
0.720 |
GeneticVariation |
BEFREE |
In TNFSF4, rs2205960 was associated with SLE independently from the effect of rs844648 (P=6.26 x 10(-3)), but not vice versa (P=0.55).
|
19357697 |
2009 |
|
rs1234315
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Meta-analysis revealed an association between the minor alleles of rs1234315 and rs10489265 of TNFSF4 and SLE in Asians (OR=1.366, 95% CI=1.295-1.440, p<1.0×10(-9); OR=1.463, 95% CI=1.208-1.771, p=9.7×10(-5)).
|
22820624 |
2012 |
|
rs1234315
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The stratification analyses showed that rs1234315 was more strongly associated with SLE patients with arthritis.
|
20012871 |
2011 |
|
rs1234315
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The present study suggested that TNFSF4 rs1234315 and rs2205960 polymorphisms were associated with SLE susceptibility.
|
31299880 |
2019 |
|
rs1234315
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Statistically significant associations with SLE and RA were detected at rs1234315, both by allele analysis (odds ratio 1.47, 95% confidence interval 1.17-1.86, p = 0.001; odds ratio 1.49, 95% confidence interval 1.15-1.92, p = 0.002; respectively), and genotype analysis (p = 0.003 and p = 7.000 × 10<sup>-5</sup>, respectively).
|
30468820 |
2019 |
|
rs1234315
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The results of our meta-analysis suggest that the TNFSF4 rs2205960 polymorphism may confer susceptibility to SLE in different populations and that the TNFSF4 rs1234315 polymorphism is associated with susceptibility to SLE in Asians.
|
22850862 |
2013 |
|
rs1234315
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The purpose of this study was to investigate the association of TNFSF4 rs2205960, rs1234315, rs8446748 and rs704840 with SLE in the Malaysian population.
|
27519474 |
2016 |
|
rs1418190
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This replication effort confirmed five reported SLE susceptibility loci reaching genome-wide levels of significance (P(meta) <5.00 × 10(-08)): TNFSF4 (rs1418190, odds ratio (OR) = 0.81, P(meta) = 1.08 × 10(-08); rs4916219, OR = 0.80, P(meta )= 7.77 × 10(-09)), IRF8 (rs2934498, OR = 1.25, P(meta) = 4.97 × 10(-09)), miR-146a (rs2431697, OR = 0.69, P(meta) = 1.15 × 10(-22)), CD44 (rs2732547, OR = 0.82, P(meta) = 1.55 × 10(-11)), and TMEM39A (rs12494314, OR = 0.84, P(meta) = 1.01 × 10(-09)).
|
25890262 |
2015 |
|
rs4916219
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This replication effort confirmed five reported SLE susceptibility loci reaching genome-wide levels of significance (P(meta) <5.00 × 10(-08)): TNFSF4 (rs1418190, odds ratio (OR) = 0.81, P(meta) = 1.08 × 10(-08); rs4916219, OR = 0.80, P(meta )= 7.77 × 10(-09)), IRF8 (rs2934498, OR = 1.25, P(meta) = 4.97 × 10(-09)), miR-146a (rs2431697, OR = 0.69, P(meta) = 1.15 × 10(-22)), CD44 (rs2732547, OR = 0.82, P(meta) = 1.55 × 10(-11)), and TMEM39A (rs12494314, OR = 0.84, P(meta) = 1.01 × 10(-09)).
|
25890262 |
2015 |
|
rs844644
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No association was found between the rs844644 and rs844648 polymorphisms and SLE.
|
22850862 |
2013 |
|
rs2205960
|
|
T |
0.880 |
GeneticVariation |
GWASCAT |
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
|
23273568 |
2013 |
|
rs2205960
|
|
T |
0.880 |
GeneticVariation |
GWASCAT |
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
|
19838195 |
2009 |