Previously studies found contribution of functional p53 Arg72Pro polymorphism (TP53 rs1042522G/C polymorphism) in the development of systemic lupus erythematosus (SLE) remains controversial.
TP53 rs1042522G/C polymorphism would be promising as an indicator of SLE as w</span>ell as the therapeuti</span>c target if its functions and mechanisms could be further investigated.
It is concluded that neither the TP53 Arg72Pro</span> polymorphism nor the MDM2 SNP309 contributes significantly to either susceptibility or disease severity in SLE.