|
rs3853839
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Genetic studies support a link between the <i>TLR7 rs3853839 C/G</i> polymorphism, which affects <i>TLR7</i> mRNA turnover, and SLE susceptibility; however, the effects of this polymorphism on B cells have not been studied.
|
31231380 |
2019 |
|
rs3853839
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Furthermore, our meta-analysis indicated a significant association between rs3853839 (TLR7) and SLE in the Asian population (OR = 0.773, 95% CI = 0.735, 0.823, P < 1.0 × 10(-9)).
|
26762473 |
2016 |
|
rs3853839
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In summary, a previously shown association between the rs3853839 SNP of TLR7 and SLE in Asian patients was also found in Danish patients.
|
24919757 |
2014 |
|
rs3853839
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The "G-G" haplotype of TLR7 rs3853839 and TLR8 rs3764880 increased risk of SLE in females (age adjusted p = 0.0032).
|
24445780 |
2014 |
|
rs3853839
|
|
|
0.080 |
GeneticVariation |
BEFREE |
These data establish rs3853839 of TLR7 as a shared risk variant of SLE in 22,613 subjects of Asian, EA, AA, and Amerindian/Hispanic ancestries (Pmeta = 2.0×10(-19), OR = 1.25 [1.20-1.32]), which confers allelic effect on transcript turnover via differential binding to the epigenetic factor miR-3148.
|
23468661 |
2013 |
|
rs3853839
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Metaanalysis showed an association between the 2 allele of rs3853839 (TLR7) and SLE in Asian subjects (OR 1.246; 95% CI 1.160, 1.388; p=2×10-9).
|
22325161 |
2012 |
|
rs3853839
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The TLR7 intronic SNPs rs179019 and rs179010 are associated with SLE independently of the 3' UTR SNP rs3853839 in Japanese women.
|
21396113 |
2011 |
|
rs3853839
|
|
|
0.080 |
GeneticVariation |
BEFREE |
By using a candidate gene approach, we identified and replicated association of a TLR7 3'UTR SNP, rs3853839 (G/C), with SLE in 9,274 Eastern Asians (P(combined) = 6.5 x 10(-10)), with a stronger effect in male than female subjects [odds ratio, male vs. female = 2.33 (95% CI = 1.64-3.30) vs. 1.24 (95% CI = 1.14-1.34); P = 4.1 x 10(-4)].
|
20733074 |
2010 |