We did not observe any association between TLR9 polymorphisms (rs187084, rs352140, rs5743836 and rs352139) and SLE under any model, after excluding the data that were inconsistent with Hardy-Weinberg equilibrium (HWE).
No association was found between SLE and the 2 alleles of the rs5743836 (TLR9) polymorphism in all overall subjects or in Europeans, but one study showed a significant association in Asians (OR 4.243; 95% CI 1.487, 12.10; p=0.007).
We performed a case-control association study and genotyped 409 Caucasian women with SLE and 509 Caucasian healthy female controls using TaqMan allelic discrimination (rs5744168) or polymerase chain reaction-restriction fragment length polymorphism analysis (rs5743836).