Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1426488816
rs1426488816
PLAA
T 0.700 GeneticVariation CLINVAR

dbSNP: rs387907272
rs387907272
MYD88
0.060 GeneticVariation BEFREE To sum up, ASO-RQ-PCR is an inexpensive, robust, and optimized method for the detection of MYD88 L265P mutation, which could be considered as a useful molecular tool during the diagnostic work-up of B-cell lymphoproliferative disorders. 24992174

2015
dbSNP: rs387907272
rs387907272
MYD88
0.060 GeneticVariation BEFREE An oncogenic gain-of-function mutation (L265P) in the human MYD88 gene has been found to be present in most cases of WM/LPL, yet is absent in most other cases of B-cell chronic lymphoproliferative disorders (LPD), including SMZL. 24842316

2014
dbSNP: rs387907272
rs387907272
MYD88
0.060 GeneticVariation BEFREE The absence of plasmacytoid cells, the presence of plasma cells predominantly outside the nodular lymphoid infiltrates, IGHV4-34 restriction and absence of MYD88 L265P mutation strongly suggest that cold agglutinin-associated lymphoproliferative disease is a distinct entity that is different from lymphoplasmacytic lymphoma. 24143001

2014
dbSNP: rs387907272
rs387907272
MYD88
0.060 GeneticVariation BEFREE This has fueled major interest in the field and as newer evidence accumulates, it is clear that that discovery of MYD88 L265P mutation may represent an important breakthrough in understanding the pathogenesis of WM and lymphoproliferative disorders. 24573383

2014
dbSNP: rs387907272
rs387907272
MYD88
0.060 GeneticVariation BEFREE MYD88 L265P somatic mutation: its usefulness in the differential diagnosis of bone marrow involvement by B-cell lymphoproliferative disorders. 23955458

2013
dbSNP: rs387907272
rs387907272
MYD88
0.060 GeneticVariation BEFREE We evaluated the MYD88 L265P mutation in Waldenström's macroglobulinemia (WM) and B-cell lymphoproliferative disorders by specific polymerase chain reaction (PCR) (sensitivity ∼10(-3)). 23446312

2013
dbSNP: rs113488022
rs113488022
BRAF
0.020 GeneticVariation BEFREE Hairy cell leukemia (HCL) is an uncommon B-cell chronic lymphoproliferative disorder whose pathogenesis and recurrence are strictly dependent on the presence of the BRAF V600E mutant. 31354304

2019
dbSNP: rs121913377
rs121913377
BRAF
0.020 GeneticVariation BEFREE Hairy cell leukemia (HCL) is an uncommon B-cell chronic lymphoproliferative disorder whose pathogenesis and recurrence are strictly dependent on the presence of the BRAF V600E mutant. 31354304

2019
dbSNP: rs113488022
rs113488022
BRAF
0.020 GeneticVariation BEFREE Investigation of the BRAF V600E mutation by pyrosequencing in lymphoproliferative disorders. 23161722

2012
dbSNP: rs121913377
rs121913377
BRAF
0.020 GeneticVariation BEFREE Investigation of the BRAF V600E mutation by pyrosequencing in lymphoproliferative disorders. 23161722

2012
dbSNP: rs77375493
rs77375493
JAK2 ; INSL6
0.020 GeneticVariation BEFREE In this patient and in 2 relatives with lymphoproliferative disorders, we searched for JAK2(V617F) mutation in lymphocytes. 19816006

2009
dbSNP: rs77375493
rs77375493
JAK2 ; INSL6
0.020 GeneticVariation BEFREE The JAK2(V617F) mutation, which has been found in patients with myeloproliferative disorders (MPD), has not yet been evaluated in lymphoproliferative disorders by any adequately sensitive techniques. 18032883

2007
dbSNP: rs1217691063
rs1217691063
MTHFR
0.020 GeneticVariation BEFREE As a conclusion, MTHFR C677T polymorphism does not increase the risk of lymphoproliferative disease, and it does not have an effect on chemotherapy response significantly; however, the patients with TT genotype have a slightly increased risk for ALL, and they also respond worse than CC genotype. 16944145

2006
dbSNP: rs1217691063
rs1217691063
MTHFR
0.020 GeneticVariation BEFREE We analysed the genotype frequencies of C677T-MTHFR in a group of 143 patients with lymphoproliferative disorders (REAL classification) and 200 controls. 11342344

2000
dbSNP: rs2071286
rs2071286
NOTCH4
0.010 GeneticVariation BEFREE We analyzed NOTCH4 rs2071286 and HLA-II rs9461776 in 3 HCV-related LPD groups (asymptomatic MC, MCS, NHL) with HCV infection without lymphoproliferative disorders. 29069725

2017
dbSNP: rs9461776
rs9461776
HLA-DRB1
0.010 GeneticVariation BEFREE We analyzed NOTCH4 rs2071286 and HLA-II rs9461776 in 3 HCV-related LPD groups (asymptomatic MC, MCS, NHL) with HCV infection without lymphoproliferative disorders. 29069725

2017
dbSNP: rs104893626
rs104893626
CXCR4 ; LOC112268426
0.010 GeneticVariation BEFREE We screened 418 patients with B-cell lymphoproliferative disorders and described the presence of the C1013G/CXCR4 warts, hypogammaglobulinemia, infections, and myelokathexis-associated mutation in 28.2% (37/131) of patients with lymphoplasmacytic lymphoma (Waldenström macroglobulinemia [WM]), being either absent or present in only 7% of other B-cell lymphomas. 24711662

2014
dbSNP: rs1472503583
rs1472503583
PWWP3A
0.010 GeneticVariation BEFREE The absence of plasmacytoid cells, the presence of plasma cells predominantly outside the nodular lymphoid infiltrates, IGHV4-34 restriction and absence of MYD88 L265P mutation strongly suggest that cold agglutinin-associated lymphoproliferative disease is a distinct entity that is different from lymphoplasmacytic lymphoma. 24143001

2014
dbSNP: rs757085537
rs757085537
PRDM1 ; ATG5
0.010 GeneticVariation BEFREE The absence of plasmacytoid cells, the presence of plasma cells predominantly outside the nodular lymphoid infiltrates, IGHV4-34 restriction and absence of MYD88 L265P mutation strongly suggest that cold agglutinin-associated lymphoproliferative disease is a distinct entity that is different from lymphoplasmacytic lymphoma. 24143001

2014
dbSNP: rs773862672
rs773862672
MTOR
0.010 GeneticVariation BEFREE We screened 418 patients with B-cell lymphoproliferative disorders and described the presence of the C1013G/CXCR4 warts, hypogammaglobulinemia, infections, and myelokathexis-associated mutation in 28.2% (37/131) of patients with lymphoplasmacytic lymphoma (Waldenström macroglobulinemia [WM]), being either absent or present in only 7% of other B-cell lymphomas. 24711662

2014
dbSNP: rs75002266
rs75002266
ORC4
0.010 GeneticVariation BEFREE Here, we describe 3 patients with B-cell lymphoproliferative disorders (2 with non-Hodgkin lymphoma and 1 with nonsecretory multiple myeloma) carrying a novel A286V mutation within ORC4L gene. 20010161

2009
dbSNP: rs201478192
rs201478192
KIDINS220
0.010 GeneticVariation BEFREE The JAK2(V617F) mutation, which has been found in patients with myeloproliferative disorders (MPD), has not yet been evaluated in lymphoproliferative disorders by any adequately sensitive techniques. 18032883

2007