|
rs747762300
|
|
|
0.010 |
GeneticVariation |
BEFREE |
343 subjects (Caucasian, African-American, Hispanic) presenting with a Major Depressive Episode were genotyped for polymorphisms A218C in intron 7 and A-6526G in the promoter region of TPH1, and monitored for suicide attempts for up to one year.
|
18977032 |
2009 |
|
rs6296
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Exploratory analyses indicated an association of the genotype and allele frequencies of the h5-HTR(1B) G861C locus with a history of substance abuse disorder (chi(2) = 9.51, df = 2, p = 0.009; chi(2) = 7.31, df = 1, p = 0.007, respectively) and with a diagnosis of a major depressive episode (chi(2) = 6.83, df = 2, p = 0.033; chi(2) = 5.81, df = 1, p = 0.016, respectively).
|
12496953 |
2003 |
|
rs334558
|
|
|
0.020 |
GeneticVariation |
BEFREE |
GSK3B rs334558 was associated with insomnia but not with MDE severity in depressed patients.
|
30081294 |
2018 |
|
rs1187352
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a naturalistic study, 569 patients with a major depressive episode requiring a new antidepressant treatment were genotyped for eight NTRK2 SNPs (rs1187352, rs1439050, rs1778933 rs2289656, rs2289657, rs2289658, rs3824519, rs56142442) and prospectively assessed for response and remission after 6 months of treatment.
|
28244805 |
2017 |
|
rs6295
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In order to further delineate the impact of 5-HT1A gene variation on pharmacoresponse in depression over 6 weeks of antidepressant treatment, the influence of the 5-HT1A-1019C/G (rs6295) polymorphism was investigated in 340 Caucasian patients with a Major Depressive Episode (DSM-IV) with particular attention to the subtype of depression (major depression and melancholic depression).
|
18387740 |
2008 |
|
rs6313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In patients, the C allele of rs6313 was more frequent in depressed patients (p=0.019) and was also associated with a more severe major depressive episode (p=0.03).
|
24801750 |
2014 |
|
rs12729558
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In sliding window analyses using PLINK of the haplotypes of KAT III, all windows which include the first SNP (rs12729558), the overall haplotype distribution (OMNIBUS) was significantly different between patients with a major depressive episode and control for all windows, with p-values ranging between 1.75 × 10=5 and 0.006.
|
21492941 |
2011 |
|
rs6265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
One hundred forty-eight Caucasian patients with a current unipolar major depressive episode (DSM IV-TR) were genotyped for the BDNF Val66Met polymorphism and assessed at baseline and after 3 and 6 months of antidepressant treatment for the 'Homoeostasis model assessment of insulin resistance' (HOMA-IR) index, a valid measure of insulin resistance based on fasting plasma insulinaemia and glycaemia.
|
30526722 |
2019 |
|
rs759834365
|
|
|
0.020 |
GeneticVariation |
BEFREE |
One hundred forty-eight Caucasian patients with a current unipolar major depressive episode (DSM IV-TR) were genotyped for the BDNF Val66Met polymorphism and assessed at baseline and after 3 and 6 months of antidepressant treatment for the 'Homoeostasis model assessment of insulin resistance' (HOMA-IR) index, a valid measure of insulin resistance based on fasting plasma insulinaemia and glycaemia.
|
30526722 |
2019 |
|
rs6265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results show a measurable, coherent, and functional BDNF pathway based on the BDNF Val66Met polymorphism and plasma BDNF levels in patients with a current MDE.
|
28848102 |
2017 |
|
rs759834365
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results show a measurable, coherent, and functional BDNF pathway based on the BDNF Val66Met polymorphism and plasma BDNF levels in patients with a current MDE.
|
28848102 |
2017 |
|
rs1801028
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The possible association of the dopamine receptor D(2) (Ser 311Cys) and D(4) exon 3 (48 base pair repeat) gene variants with the antidepressant activity of selective serotonin reuptake inhibitors (SSRIs) was investigated in a sample of 364 inpatients affected by a major depressive episode treated with fluvoxamine, 300 mg/day (n=266), or paroxetine, 20-40 mg/day (n=98).
|
11728608 |
2001 |
|
rs17710780
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The three top scoring SNPs (rs12248560, rs878567, rs17710780) were subsequently combined into an unweighted GRS, which was included in linear and logistic regression models using the CES-D score, occurrence of a major depressive episode (MDE) during follow-up and regular antidepressant treatment during the 6 months preceding follow-up assessment as outcomes.
|
31617956 |
2020 |
|
rs25531
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To further delineate the impact of 5-HTT gene variation on psychopathology in depression, in this analysis the influence of the 5-HTTLPR and the functionally closely related 5-HTT rs25531 was investigated in 340 Caucasian patients with a major depressive episode (DSM-IV) with particular attention to the subtype of depression (melancholic depression versus atypical depression) applying logistic regression models adjusted for age and gender.
|
18050262 |
2008 |
|
rs7997012
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two serotonin 2A receptor (HTR2A) SNPs recently reported to be associated with antidepressant treatment response in STARD (rs7997012; rs1928040) were analyzed for association with treatment response in two independent Caucasian samples of patients with a Major Depressive Episode.
|
19758789 |
2010 |
|
rs1928040
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two serotonin 2A receptor (HTR2A) SNPs recently reported to be associated with antidepressant treatment response in STARD (rs7997012; rs1928040) were analyzed for association with treatment response in two independent Caucasian samples of patients with a Major Depressive Episode.
|
19758789 |
2010 |
|
rs6295
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We studied the association of rs6295 with the amount of stress in early life and preceding hospitalization for a major depressive episode in course of bipolar disorder.
|
21397953 |
2011 |
|
rs334558
|
|
|
0.020 |
GeneticVariation |
BEFREE |
With a translational approach, we studied the effect of 5-HTTLPR and rs334558 on antidepressant response to sleep deprivation in a unique sample of 122 patients affected by a major depressive episode in course of bipolar disorder.
|
22119086 |
2012 |