Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs920778
rs920778
0.040 GeneticVariation BEFREE A single nucleotide polymorphism (SNP) rs920778 in the HOTAIR gene, has been recurrently studied for susceptibility to many cancers including oesophageal cancer, gastric cancer, lung cancer, and hepatocellular carcinoma. 31759985

2020

dbSNP: rs2758339
rs2758339
0.010 GeneticVariation BEFREE This study indicates that the SOD2 polymorphism (rs2758339, rs5746136) is associated with increased risk of gastric cancer, especially in smoker individuals. 30242560

2020

dbSNP: rs5746136
rs5746136
0.010 GeneticVariation BEFREE This study indicates that the SOD2 polymorphism (rs2758339, rs5746136) is associated with increased risk of gastric cancer, especially in smoker individuals. 30242560

2020

dbSNP: rs8193
rs8193
0.010 GeneticVariation BEFREE rs8193 is statistically associated with the risk of malignancy, lymph node spread and stage of gastric cancer in Iranian population. 31376327

2020

dbSNP: rs2274223
rs2274223
0.100 GeneticVariation BEFREE Collectively, this meta-analysis demonstrated that <i>CTLA-4</i> rs5742909 and <i>PLCE1</i> rs2274223 polymorphisms may confer susceptibility to GC, especially for East Asians. 31767616

2019

dbSNP: rs2274223
rs2274223
0.100 GeneticVariation BEFREE Results showed that the minor alleles of rs3765524, rs2274223, and rs10509670 were associated with increased risk of EC and GC. 30931333

2019

dbSNP: rs2274223
rs2274223
0.100 GeneticVariation BEFREE Our findings indicated that the PLCE1 rs2274223 variant might serve as a promising genetic biomarker of esophageal and gastric cancer in East Asians. 30784231

2019

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.100 GeneticVariation BEFREE Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU). 31839644

2019

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.100 GeneticVariation BEFREE We found that both rs2294008 (CT vs. CC, OR = 1.55, 95% CI = 1.20-1.99, <i>P</i><0.001 and CT+TT vs. CC, OR = 1.38, 95% CI = 1.09-1.74, <i>P</i>=0.008) and rs2976392 (GA vs. GG, OR = 1.61, 95% CI = 1.25-2.07, <i>P</i><0.001 and GA+AA vs. GG, OR = 1.52, 95% CI = 1.20-1.92, <i>P</i><0.001) were associated with an increased gastric cancer. 31416884

2019

dbSNP: rs2976392
rs2976392
PSCA ; JRK
0.100 GeneticVariation BEFREE We found that both rs2294008 (CT vs. CC, OR = 1.55, 95% CI = 1.20-1.99, <i>P</i><0.001 and CT+TT vs. CC, OR = 1.38, 95% CI = 1.09-1.74, <i>P</i>=0.008) and rs2976392</span> (GA vs. GG, OR = 1.61, 95% CI = 1.25-2.07, <i>P</i><0.001 and GA+AA vs. GG, OR = 1.52, 95% CI = 1.20-1.92, <i>P</i><0.001) were associated with an increased gastric cancer. 31416884

2019

dbSNP: rs4986790
rs4986790
0.100 GeneticVariation BEFREE Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129). 31516756

2019

dbSNP: rs751402
rs751402
0.100 GeneticVariation BEFREE Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129). 31516756

2019

dbSNP: rs763780
rs763780
0.100 GeneticVariation BEFREE Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129). 31516756

2019

dbSNP: rs1801282
rs1801282
0.080 GeneticVariation BEFREE Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129). 31516756

2019

dbSNP: rs2094258
rs2094258
0.060 GeneticVariation BEFREE The increase in C alleles of rs2094258 [hazard ratio (HR) = 1.19, 95% confidence interval (CI): 1.02-1.45, <i>P</i> = 0.037] were associated with the long-term survival of GC cases. 31558863

2019

dbSNP: rs895819
rs895819
0.060 GeneticVariation BEFREE Our results find that rs895819 contributed to occurrence of gastric cancer in co-dominant model in Chinese population. 31054359

2019

dbSNP: rs1800796
rs1800796
0.040 GeneticVariation BEFREE The stratified analysis showed that rs1</span>800796</span> G allele carriers (GG/CG) were associated with an increased risk of gastri</span>c cancer in the following subgroups: age >64 years old (OR<sub>adjusted</sub> = 1.67, 95% CI = 1.17-2.39), female (OR<sub>adjusted</sub> = 1.82, 95% CI = 1.09-3.05), positive for <i>H. pylori</i> infection (OR<sub>adjusted</sub> = 1.54, 95% CI = 1.07-2.22), non-cardiac gastric cancer (OR<sub>adjusted</sub> = 1.53, 95% CI = 1.15-2.04), stage T3-T4 tumor (OR<sub>adjusted</sub> = 1.41, 95% CI = 1.06-1.88), and gastric cancer with median to high differentiation (OR<sub>adjusted</sub> = 1.45, 95% CI = 1.08-1.96). 31312381

2019

dbSNP: rs1800871
rs1800871
0.040 GeneticVariation BEFREE SNPs in TGFβ (- 509 C/T, rs1800469) and IL-10 (- 819 C/T, rs1800871) promoters were associated with a lower risk for GC in a Mexican population. 31092242

2019

dbSNP: rs4938723
rs4938723
0.040 GeneticVariation BEFREE The findings did not support an association between rs4938723 variant and digestive tract as well as gastric cancer. 30203457

2019

dbSNP: rs1047972
rs1047972
0.030 GeneticVariation BEFREE Our results revealed that AURKA (rs1047972 and rs911160), AURKB (rs2241909 and rs2289590) and AURKC (rs11084490) are associated with a higher risk of GC susceptibility. 31521144

2019

dbSNP: rs10889677
rs10889677
0.030 GeneticVariation BEFREE The <i>let-7</i>-related polymorphism rs3811463 in <i>LIN28A</i> is associated with the susceptibility to gastric cancer and the <i>let-7</i>-related polymorphism rs10889677 in <i>IL23R</i> is associated with the prognosis of gastric cancer. 30833806

2019

dbSNP: rs16999593
rs16999593
0.030 GeneticVariation BEFREE Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129). 31516756

2019

dbSNP: rs2296147
rs2296147
0.030 GeneticVariation BEFREE None of the examined loci were statistically associated with GC risk, although rs2296147 was marginally associated with GC risk (<i>P</i> = 0.050). 31558863

2019

dbSNP: rs5744174
rs5744174
0.030 GeneticVariation BEFREE TLR5 rs5744174 C/C genotype was associated with GC, lower IgG anti <i>H. pylori</i> response and a higher <i>H. pylori</i> flagellin A abundance and motility.In a subset of patients with AAG, <i>H. pylori</i> strains showed a reduction of the flagellin A abundance and a moderate motility compared with strains from GC patients, a prerequisite for active colonization of the deeper layers of the mucosa, host immune response and inflammation. 31083432

2019

dbSNP: rs13428812
rs13428812
0.020 GeneticVariation BEFREE The present case-control study examined the associations between single nucleotide polymorphisms (rs6733868 and rs13428812) in <i>DNMT3A</i> and cancer susceptibility in 343 patients with gastric cancer and 708 subjects without gastric malignancies on upper gastro-duodenal endoscopy. 30867787

2019