rs920778
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (SNP) rs920778 in the HOTAIR gene, has been recurrently studied for susceptibility to many cancers including oesophageal cancer, gastric cancer, lung cancer, and hepatocellular carcinoma.
|
31759985 |
2020 |
rs2758339
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study indicates that the SOD2 polymorphism (rs2758339, rs5746136) is associated with increased risk of gastric cancer, especially in smoker individuals.
|
30242560 |
2020 |
rs5746136
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study indicates that the SOD2 polymorphism (rs2758339, rs5746136) is associated with increased risk of gastric cancer, especially in smoker individuals.
|
30242560 |
2020 |
rs8193
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs8193 is statistically associated with the risk of malignancy, lymph node spread and stage of gastric cancer in Iranian population.
|
31376327 |
2020 |
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Collectively, this meta-analysis demonstrated that <i>CTLA-4</i> rs5742909 and <i>PLCE1</i> rs2274223 polymorphisms may confer susceptibility to GC, especially for East Asians.
|
31767616 |
2019 |
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results showed that the minor alleles of rs3765524, rs2274223, and rs10509670 were associated with increased risk of EC and GC.
|
30931333 |
2019 |
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings indicated that the PLCE1 rs2274223 variant might serve as a promising genetic biomarker of esophageal and gastric cancer in East Asians.
|
30784231 |
2019 |
rs2294008
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU).
|
31839644 |
2019 |
rs2294008
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that both rs2294008 (CT vs. CC, OR = 1.55, 95% CI = 1.20-1.99, <i>P</i><0.001 and CT+TT vs. CC, OR = 1.38, 95% CI = 1.09-1.74, <i>P</i>=0.008) and rs2976392 (GA vs. GG, OR = 1.61, 95% CI = 1.25-2.07, <i>P</i><0.001 and GA+AA vs. GG, OR = 1.52, 95% CI = 1.20-1.92, <i>P</i><0.001) were associated with an increased gastric cancer.
|
31416884 |
2019 |
rs2976392
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that both rs2294008 (CT vs. CC, OR = 1.55, 95% CI = 1.20-1.99, <i>P</i><0.001 and CT+TT vs. CC, OR = 1.38, 95% CI = 1.09-1.74, <i>P</i>=0.008) and rs2976392</span> (GA vs. GG, OR = 1.61, 95% CI = 1.25-2.07, <i>P</i><0.001 and GA+AA vs. GG, OR = 1.52, 95% CI = 1.20-1.92, <i>P</i><0.001) were associated with an increased gastric cancer.
|
31416884 |
2019 |
rs4986790
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129).
|
31516756 |
2019 |
rs751402
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129).
|
31516756 |
2019 |
rs763780
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129).
|
31516756 |
2019 |
rs1801282
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129).
|
31516756 |
2019 |
rs2094258
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The increase in C alleles of rs2094258 [hazard ratio (HR) = 1.19, 95% confidence interval (CI): 1.02-1.45, <i>P</i> = 0.037] were associated with the long-term survival of GC cases.
|
31558863 |
2019 |
rs895819
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Our results find that rs895819 contributed to occurrence of gastric cancer in co-dominant model in Chinese population.
|
31054359 |
2019 |
rs1800796
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The stratified analysis showed that rs1</span>800796</span> G allele carriers (GG/CG) were associated with an increased risk of gastri</span>c cancer in the following subgroups: age >64 years old (OR<sub>adjusted</sub> = 1.67, 95% CI = 1.17-2.39), female (OR<sub>adjusted</sub> = 1.82, 95% CI = 1.09-3.05), positive for <i>H. pylori</i> infection (OR<sub>adjusted</sub> = 1.54, 95% CI = 1.07-2.22), non-cardiac gastric cancer (OR<sub>adjusted</sub> = 1.53, 95% CI = 1.15-2.04), stage T3-T4 tumor (OR<sub>adjusted</sub> = 1.41, 95% CI = 1.06-1.88), and gastric cancer with median to high differentiation (OR<sub>adjusted</sub> = 1.45, 95% CI = 1.08-1.96).
|
31312381 |
2019 |
rs1800871
|
|
|
0.040 |
GeneticVariation |
BEFREE |
SNPs in TGFβ (- 509 C/T, rs1800469) and IL-10 (- 819 C/T, rs1800871) promoters were associated with a lower risk for GC in a Mexican population.
|
31092242 |
2019 |
rs4938723
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The findings did not support an association between rs4938723 variant and digestive tract as well as gastric cancer.
|
30203457 |
2019 |
rs1047972
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our results revealed that AURKA (rs1047972 and rs911160), AURKB (rs2241909 and rs2289590) and AURKC (rs11084490) are associated with a higher risk of GC susceptibility.
|
31521144 |
2019 |
rs10889677
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The <i>let-7</i>-related polymorphism rs3811463 in <i>LIN28A</i> is associated with the susceptibility to gastric cancer and the <i>let-7</i>-related polymorphism rs10889677 in <i>IL23R</i> is associated with the prognosis of gastric cancer.
|
30833806 |
2019 |
rs16999593
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129).
|
31516756 |
2019 |
rs2296147
|
|
|
0.030 |
GeneticVariation |
BEFREE |
None of the examined loci were statistically associated with GC risk, although rs2296147 was marginally associated with GC risk (<i>P</i> = 0.050).
|
31558863 |
2019 |
rs5744174
|
|
|
0.030 |
GeneticVariation |
BEFREE |
TLR5 rs5744174 C/C genotype was associated with GC, lower IgG anti <i>H. pylori</i> response and a higher <i>H. pylori</i> flagellin A abundance and motility.In a subset of patients with AAG, <i>H. pylori</i> strains showed a reduction of the flagellin A abundance and a moderate motility compared with strains from GC patients, a prerequisite for active colonization of the deeper layers of the mucosa, host immune response and inflammation.
|
31083432 |
2019 |
rs13428812
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The present case-control study examined the associations between single nucleotide polymorphisms (rs6733868 and rs13428812) in <i>DNMT3A</i> and cancer susceptibility in 343 patients with gastric cancer and 708 subjects without gastric malignancies on upper gastro-duodenal endoscopy.
|
30867787 |
2019 |