|
rs10004195
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We concluded that TLR-1 rs4833095 and TLR10 rs10004195 confer susceptibility to development of gastroduodenal disease, especially GC in H.pylori disease.
|
26559190 |
2015 |
|
rs10022537
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped four selected, potentially functional CD133 SNPs (rs2240688A>C, rs7686732C>G, rs10022537T>A, and rs3130C>T) and used logistic regression analysis for associations of these SNPs with GC risk and Cox hazards regression analysis for survival.
|
24302553 |
2015 |
|
rs1002765
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found that let-7e rs8111742 and miR-4795 rs1002765 were associated with the risk of gastric cancer in the H. pylori-positive subgroup.
|
28067243 |
2017 |
|
rs1002765
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the miRNAs SNPs (let-7e rs8111742 and miR-4795 rs1002765) might have more superior efficiency when combined with PGC SNPs and/or H. pylori for GC or AG risk than a single SNP on its own.
|
26988755 |
2016 |
|
rs10052016
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After combining these two studies, we found that the G allele of rs10052016 (at 132 kb upstream of TERT) was significantly associated with a decreased risk of gastric cancer (OR = 0.76, 95% CI = 0.67-0.87, P = 5.35 × 10(-5)).
|
23901064 |
2013 |
|
rs10052657
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic variants of rs2274223 in PLCE1 at 10q23.33 (per G allele: odds ratio (OR) = 1.26, 95% confidence interval (CI): 1.16-1.38, P = 6.51 × 10<sup>-8</sup>), rs10052657 in PDE4D at 5q11.2 (per C allele: OR = 1.12, 95% CI: 1.01-1.25, P = 3.28 × 10<sup>-2</sup>) and rs671 in ALDH2 at 12q24.12 (per A-allele: OR = 0.83, 95% CI: 0.75-0.91, P = 1.14 × 10<sup>-4</sup>) were significantly associated with GC risk.
|
30202044 |
2018 |
|
rs10074991
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Most notably, subjects with a homozygous minor allele in SNP rs10074991 showed 2.15 times the risk of gastric cancer</span> as subjects without a minor allele.
|
25024613 |
2014 |
|
rs10074991
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Haplotype analysis indicated A-G-C-T-C-G haplotype (rs6882903, rs10074991, rs13361707, rs3805490, rs154268 and rs461404) is associated with increased risk of g</span>astric cancer (OR = 1.29, 95%CI: 1.02-1.62, p = 0.035).
|
30253744 |
2018 |
|
rs10088390
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, haplotype analysis showed that the A rs1127379 G rs10088390 haplotype conferred a risk effect for gastric cancer.
|
27739564 |
2017 |
|
rs1011445550
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Survivin -31C/G polymorphism and gastric cancer risk in a Brazilian population.
|
21161671 |
2011 |
|
rs10116253
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying CC genotype of rs10116253 and TT genotype of rs1927911 had a significantly decreased risk of GC (adjusted OR=0.33, 95% CI 0.18-0.60, P<0.001 and adjusted OR=0.37, 95% CI 0.21-0.67, P=0.001 respectively), compared with TT genotype of rs10116253 and CC genotype of rs1927911.
|
24365597 |
2014 |
|
rs1016343
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the stratification analyses, the recessive model indicated that the rs1016343 TT genotype was significantly associated with decreased GC risk in individuals aged <60 years showing lymph node metastasis (LNM)-negative results.
|
31288430 |
2019 |
|
rs1042028
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The prognostic significance of the SULT1A1 Arg213His polymorphism with respect to staging, differentiation and histological type of gastric cancer was also evaluated.
|
16137826 |
2005 |
|
rs10421916
|
|
|
0.010 |
GeneticVariation |
BEFREE |
INSL3 rs10421916 and rs11088680 had both a 0.8-fold decreased OR for gastric cancer (95% CIs = 0.7-0.97; and 0.7-0.9, respectively).
|
23028900 |
2012 |
|
rs1042229
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Homozygous K alleles of rs1042229 were associated with stomach cancer (Odds ratio [OR]=1.62, confidence interval [CI]=1.05-2.48, p=0.028).
|
21216225 |
2011 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The p53 R72P seems not to be a potential risk factor for development of GC among Iranian patients, but our data suggest that MDM2 SNP309 might modify the risk related to GC.
|
25227851 |
2014 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that the polymorphisms of P53 (rs1042522) and MDM2 (rs2279744) are associated with gastric cancer risk, whereas no significant association was observed between variant genotype of other two polymorphisms (MDM4 rs1380576 and Hausp rs1529916) and gastric cancer risk.
|
25479941 |
2015 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that p53 Arg72Pro polymorphism is associated with increased risk of gastric cancer in Asians.
|
22780299 |
2012 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, a significant association was detected between the p53 Arg72Pro polymorphism and GC risk (Pro-allele vs. Arg-allele: OR=1.05, 95%CI=1.01-1.08; Pro/Pro vs. Arg/Arg: OR=1.13, 95%CI=1.04-1.22).
|
22901123 |
2012 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The purpose of this study was to examine the role of the miR-34b/c rs4938723 and TP53 Arg72Pro polymorphisms in the susceptibility of gastric cancer.
|
25658980 |
2015 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Aiming to evaluate the associations between host cell proliferation-related genetic polymorphisms and gastric cancer susceptibility, we reviewed the related studies published until 15 September 2008 and quantitatively summarized the associations of the most widely studied polymorphisms (TP53 Arg72Pro, L-myc EcoRI) using meta-analysis.
|
19536170 |
2009 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that Pro allele in P53 Arg72Pro is significantly associated with the increased risks of digestive tract cancers, especially for Asians, and for gastric cancer, colorectal cancer and gallbladder and pancreatic cancer.
|
21376265 |
2011 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that TP53 rs1042522 polymorphism might contribute to the susceptibility of gastric cancer under the dominant model, especially in Eastern Asians.
|
24534481 |
2014 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The purpose of the present hospital-based case-control study was to investigate the association between the miR-34b/c rs4938723 and TP53 Arg72Pro polymorphisms and the risk of gastric cancer.
|
25190020 |
2014 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests the Pro variant of TP53 Arg72Pro contributes to gastric cancer risk in Asians.
|
22631671 |
2012 |