Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1917799
rs1917799
0.030 GeneticVariation BEFREE An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 rs1917799 polymorphism was observed for the risk of gastric cancer (P interaction = 0.026); and interaction effects of pri-let-7a-1 rs10739971 polymorphism with PGC rs6458238 polymorphism (P interaction = 0.012) and PGC rs9471643 polymorphism (P interaction = 0.039) were observed for the risk of atrophic gastritis. 24586594

2014

dbSNP: rs1917799
rs1917799
0.030 GeneticVariation BEFREE ERCC6 rs1917799 GG genotype might be associated with increased GC risk in Chinese, especially in males. 24289633

2013

dbSNP: rs1917799
rs1917799
0.030 GeneticVariation BEFREE ERCC6 rs1917799 also showed a significant interaction with ERCC8 rs158916 to reduce gastric cancer risk. 28562347

2017

dbSNP: rs12155758
rs12155758
0.020 GeneticVariation BEFREE Although rs12155758 and rs9297976 were also found associated with GC, this association appeared to be due to linkage disequilibrium with rs2294008. 21681742

2012

dbSNP: rs12155758
rs12155758
0.020 GeneticVariation BEFREE SNP rs12155758 was not associated with risk of gastric preneoplastic lesions, but we confirmed its association with higher GC risk (OR 1.95; 95% CI 1.29-2.97 for dominant model). 24023815

2013

dbSNP: rs36012910
rs36012910
0.020 GeneticVariation BEFREE The rs36012910 allele G was associated with an increased risk of G</span>C compared to the rs36012910 allele A. 23053986

2012

dbSNP: rs36012910
rs36012910
0.020 GeneticVariation BEFREE Lastly, a systematic review on 7 studies for 17 SNPs suggested that rs36012910, rs7560488 and rs6087990 might have a potential effect on GC initiation. 27789275

2016

dbSNP: rs4460629
rs4460629
0.020 GeneticVariation BEFREE Two SNPs at 1q22, rs4072037 and rs4460629, were significantly associated with a reduced risk of GC, best fitting the dominant genetic model. 22938415

2012

dbSNP: rs4460629
rs4460629
0.020 GeneticVariation BEFREE Recently, a genome-wide association study of gastric cancer (GC) reported the significant association of seven genetic variants (rs4072037 and rs4460629 on 1q22; rs753724, rs11187842, rs3765524, rs2274223, and rs3781264 on 10q23) with GC in a Chinese population. 22740136

2012

dbSNP: rs7560488
rs7560488
0.020 GeneticVariation BEFREE Our results suggest that the genetic variations in the DNMT3A1 promoter contribute to the susceptibility to GC and also provide an insight that tagSNP rs7560488 T>C may be a promising biomarker for predicting GC genetic susceptibility and a valuable information in GC pathogenesis. 24667323

2014

dbSNP: rs7560488
rs7560488
0.020 GeneticVariation BEFREE Lastly, a systematic review on 7 studies for 17 SNPs suggested that rs36012910, rs7560488 and rs6087990 might have a potential effect on GC initiation. 27789275

2016

dbSNP: rs889312
rs889312
0.020 GeneticVariation BEFREE Cox regression analysis, log-rank test and Kaplan-Meier method were used to explore the link between MAP3K1 rs889312 variant and overall survival (OS) of GC. 31686841

2019

dbSNP: rs889312
rs889312
0.020 GeneticVariation BEFREE Considering steroid hormone-mediated signaling pathways have an important role in the progression of gastric cancer, we hypothesized that MAP3K1 rs889312 may be associated with survival outcomes in gastric cancer. 24759887

2014

dbSNP: rs10116253
rs10116253
0.010 GeneticVariation BEFREE Individuals carrying CC genotype of rs10116253 and TT genotype of rs1927911 had a significantly decreased risk of GC (adjusted OR=0.33, 95% CI 0.18-0.60, P<0.001 and adjusted OR=0.37, 95% CI 0.21-0.67, P=0.001 respectively), compared with TT genotype of rs10116253 and CC genotype of rs1927911. 24365597

2014

dbSNP: rs10484761
rs10484761
0.010 GeneticVariation BEFREE Genetic variation rs10484761 on 6p21.1 derived from a genome-wide association study is associated with gastric cancer survival in a Chinese population. 24325909

2014

dbSNP: rs10811474
rs10811474
0.010 GeneticVariation BEFREE ASSET analyses identified four SNPs significantly associated with multiple cancers: rs3731239 (CDKN2A intronic) with ESCC, GC and BC (P = 3.96 × 10(-) (4)); rs10811474 (3' of IFNW1) with RCC and BrC (P = 0.001); rs12683422 (LINGO2 intronic) with RCC and BC (P = 5.93 × 10(-) (4)) and rs10511729 (3' of ELAVL2) with LC and BrC (P = 8.63 × 10(-) (4)). 25239644

2014

dbSNP: rs10983755
rs10983755
0.010 GeneticVariation BEFREE Using a case-control study, we analyzed the genotypic distribution of TLR4 rs10983755 (-2081G/A) and rs11536878 in a Chinese population and investigated the effect of their interactions with Helicobacter pylori infection on susceptibility to gastric cancer (GC) and atrophic gastritis (AG). 25084512

2014

dbSNP: rs11040869
rs11040869
0.010 GeneticVariation BEFREE Meanwhile, minor allele homozygotes of rs3793964 and rs11040869 were significantly associated with a decreased risk of non-cardia gastric cancer when compared with their major allele homozygotes. 24935372

2014

dbSNP: rs11088680
rs11088680
0.010 GeneticVariation BEFREE INSL3 rs10421916 and rs11088680 had both a 0.8-fold decreased OR for gastric cancer (95% CIs = 0.7-0.97; and 0.7-0.9, respectively). 23028900

2012

dbSNP: rs12083239
rs12083239
0.010 GeneticVariation BEFREE MFSD2A rs12083239 GC genotype and TRIT1 rs2172362 or rs230310 homozygous genotype were associated with Lauren's classification (GC versus GG, adjusted OR, 1.69; GC versus GG/CC, adjusted OR, 1.74) and tumor site (rs2172362: CC versus CT, adjusted OR, 1.71; CC/TT versus CT, adjusted OR, 1.62; rs230310: CC versus CT, adjusted OR, 1.75; CC/TT versus CT, adjusted OR, 1.67) of gastric cancer, respectively. 23349019

2013

dbSNP: rs12521436
rs12521436
0.010 GeneticVariation BEFREE Finally, we made a joint effect analysis of rs12521436, rs33388 and rs4912913 on risk of gastric cancer (<i>P<sub>Trend</sub></i> =2.83×10<sup>-5</sup>). 29285253

2017

dbSNP: rs12615966
rs12615966
0.010 GeneticVariation BEFREE Additionally, genetic model analyses showed that rs2689154 was associated with a reduced risk of GC</span> under the recessive model (adjusted OR = 0.46, 95% CI: 0.22-0.98, P = 0.037), and rs12615966 in FOXF1 was associated with an increased risk of GC in both the dominant and log-additive models after adjusted for age and gender (adjusted OR = 1.36, 95% CI: 1.02-1.81, P = 0.033; adjusted OR = 1.36, 95% CI: 1.05-1.75, P = 0.018, respectively). 28404937

2017

dbSNP: rs12826786
rs12826786
0.010 GeneticVariation BEFREE No statistically significant differences were found in the allele or genotype distributions of the HOTAIR rs12826786 C>T polymorphism among GC and healthy control subjects (P > 0.05). 28342055

2017

dbSNP: rs13361189
rs13361189
0.010 GeneticVariation BEFREE In contrast, the rs13361189 IRGM polymorphism was not associated with susceptibility to gastric cancer. 22713085

2012

dbSNP: rs1887427
rs1887427
0.010 GeneticVariation BEFREE The JAK2 gene rs2230724 and rs1887427 polymorphisms are associated with an increased risk of gastric cancer in a Chinese Han population. 23717640

2013