|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results showed that the minor alleles of rs3765524, rs2274223, and rs10509670 were associated with increased risk of EC and GC.
|
30931333 |
2019 |
|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings indicated that the PLCE1 rs2274223 variant might serve as a promising genetic biomarker of esophageal and gastric cancer in East Asians.
|
30784231 |
2019 |
|
rs2294008
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU).
|
31839644 |
2019 |
|
rs2294008
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that both rs2294008 (CT vs. CC, OR = 1.55, 95% CI = 1.20-1.99, <i>P</i><0.001 and CT+TT vs. CC, OR = 1.38, 95% CI = 1.09-1.74, <i>P</i>=0.008) and rs2976392 (GA vs. GG, OR = 1.61, 95% CI = 1.25-2.07, <i>P</i><0.001 and GA+AA vs. GG, OR = 1.52, 95% CI = 1.20-1.92, <i>P</i><0.001) were associated with an increased gastric cancer.
|
31416884 |
2019 |
|
rs2976392
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that both rs2294008 (CT vs. CC, OR = 1.55, 95% CI = 1.20-1.99, <i>P</i><0.001 and CT+TT vs. CC, OR = 1.38, 95% CI = 1.09-1.74, <i>P</i>=0.008) and rs2976392</span> (GA vs. GG, OR = 1.61, 95% CI = 1.25-2.07, <i>P</i><0.001 and GA+AA vs. GG, OR = 1.52, 95% CI = 1.20-1.92, <i>P</i><0.001) were associated with an increased gastric cancer.
|
31416884 |
2019 |
|
rs4986790
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129).
|
31516756 |
2019 |
|
rs751402
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129).
|
31516756 |
2019 |
|
rs763780
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129).
|
31516756 |
2019 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the case-control study, rs1042522 (<i>TP53</i>) was associated with a stronger risk for developing gastric cancer in the sample stratified for diffuse subtype patients when compared to the risk observed for the total cases; CTC haplotype (rs699947/rs833061/rs2010963 <i>VEGFA</i>) was associated with risk while rs699947 was associated with protection for gastric malignancy in the total sample.
|
30551681 |
2018 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
5-fluorouracil (5-Fu) metabolism associated enzyme, methylenetetrahydrofolate reductase (MTHFR)'s polymorphism C677T can affect enzyme activity and a series of studies have been performed to examine the association of this MTHFR polymorphism with the clinical outcomes of gastric cancer (GC) patients treated with 5-Fu based chemotherapies.
|
29581785 |
2018 |
|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic variants of rs2274223 in PLCE1 at 10q23.33 (per G allele: odds ratio (OR) = 1.26, 95% confidence interval (CI): 1.16-1.38, P = 6.51 × 10<sup>-8</sup>), rs10052657 in PDE4D at 5q11.2 (per C allele: OR = 1.12, 95% CI: 1.01-1.25, P = 3.28 × 10<sup>-2</sup>) and rs671 in ALDH2 at 12q24.12 (per A-allele: OR = 0.83, 95% CI: 0.75-0.91, P = 1.14 × 10<sup>-4</sup>) were significantly associated with GC risk.
|
30202044 |
2018 |
|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that rs2274223 A>G in PLCE1 was associated with increased GC survival in both training set (P = .011), which was independently replicated in validation set 1 (P = .045), but not in validation set 2.
|
29983348 |
2018 |
|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results of subgroup analysis showed that the rs2274223 polymorphism was associated with higher risk for esophageal cancer and gastric cancer relative to colorectal cancer and head and neck cancer.
|
30619753 |
2018 |
|
rs2275913
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The pooled estimate revealed an association between IL-17A rs2275913 polymorphism and the risk of GC under all genetic models (A vs. G, OR 1.187, 95% CI 1.086-1.297, P < 0.001; GA vs. GG, OR 1.108, 95% CI 1.008-1.218, P = 0.033; AA vs. GG, OR 1.484, 95% CI 1.236-1.781, P < 0.001), while no evidence of association was found with IL-17A rs3748067 or IL-17F rs763780 polymorphisms.
|
29860554 |
2018 |
|
rs2294008
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conducted a case-control association study of <i>H. pylori</i>-infected gastritis and gastric cancer. rs2294008 was associated with the progression to chronic active gastritis (<i>P =</i> 9.4 × 10<sup>-5</sup>; odds ratio = 3.88, TT + TC vs CC genotype), but not with <i>H. pylori</i> infection <i>per se</i> nor with the progression from active gastritis to gastric cancer.
|
29423095 |
2018 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, we did not find any association of polymorphism of XRCC1 Arg399Gln (OR = 1.56; 95% CI: 0.32-7.82) and XPD Lys751Gln (OR = 0.46; CI: 0.10-2.19) with GC risk in the study population.
|
30225185 |
2018 |
|
rs4072037
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study confirms the protective effect of MUC1 rs40</span>72037 polymorphism on the risk of GC under the dominant model.
|
28489708 |
2018 |
|
rs751402
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis indicates that the XPG rs751402 polymorphism may be a risk factor for GC in the Chinese population.
|
29148016 |
2018 |
|
rs763780
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The pooled estimate revealed an association between IL-17A rs2275913 polymorphism and the risk of GC under all genetic models (A vs. G, OR 1.187, 95% CI 1.086-1.297, P < 0.001; GA vs. GG, OR 1.108, 95% CI 1.008-1.218, P = 0.033; AA vs. GG, OR 1.484, 95% CI 1.236-1.781, P < 0.001), while no evidence of association was found with IL-17A rs3748067 or IL-17F rs763780 polymorphisms.
|
29860554 |
2018 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis showed there was no association between hOGG1 rs1052133 and GC.
|
28415729 |
2017 |
|
rs11614913
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results demonstrated that miR-196a2 rs11614913 was significantly associated with a decreased cancer risk, in particular with a decreased risk for colorectal cancer and gastric cancer, or for Asian population subgroup.
|
29371991 |
2017 |
|
rs2294008
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, subtype-specific associations were observed for gastric cardia adenocarcinomas at MUC1/TRIM46/1q22 rs2070803 [HRAA versus GA+GG = 2.16; 95% confidence interval (CI) = 1.24-3.78; P = 0.0068] and LTA/TNF/6p21.33 rs1799724 (HRTT+CT versus CC = 1.30; 95% CI = 1.07-1.57; P = 0.0077), and for diffuse-type GC at PSCA/8q24.3 rs2294008 (HRTT versus CT+CC = 1.99; 95% CI = 1.33-2.97; P = 7.8E-04).
|
29028942 |
2017 |
|
rs2294008
|
|
|
0.100 |
GeneticVariation |
BEFREE |
PSCA rs2294008/rs2976392 showed a significant, multiplicative interaction with H. pylori infection in risk of GC.
|
28220687 |
2017 |
|
rs2910164
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A significant association was found between rs2910164</span> and GC risk under all genetic models (CC vs. GG, OR = 0.76, 95% CI = 0.66-0.87; CC vs. GC+GG, OR = 0.84, 95% CI = 0.71-0.99; CC+GC vs. GG, OR = 0.82, 95% CI = 0.73-0.91) for the total data.
|
26202478 |
2017 |
|
rs2976392
|
|
|
0.100 |
GeneticVariation |
BEFREE |
PSCA rs2294008/rs2976392 showed a significant, multiplicative interaction with H. pylori infection in risk of GC.
|
28220687 |
2017 |