|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that the polymorphisms of P53 (rs1042522) and MDM2 (rs2279744) are associated with gastric cancer risk, whereas no significant association was observed between variant genotype of other two polymorphisms (MDM4 rs1380576 and Hausp rs1529916) and gastric cancer risk.
|
25479941 |
2015 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that p53 Arg72Pro polymorphism is associated with increased risk of gastric cancer in Asians.
|
22780299 |
2012 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, a significant association was detected between the p53 Arg72Pro polymorphism and GC risk (Pro-allele vs. Arg-allele: OR=1.05, 95%CI=1.01-1.08; Pro/Pro vs. Arg/Arg: OR=1.13, 95%CI=1.04-1.22).
|
22901123 |
2012 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The purpose of this study was to examine the role of the miR-34b/c rs4938723 and TP53 Arg72Pro polymorphisms in the susceptibility of gastric cancer.
|
25658980 |
2015 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Aiming to evaluate the associations between host cell proliferation-related genetic polymorphisms and gastric cancer susceptibility, we reviewed the related studies published until 15 September 2008 and quantitatively summarized the associations of the most widely studied polymorphisms (TP53 Arg72Pro, L-myc EcoRI) using meta-analysis.
|
19536170 |
2009 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that Pro allele in P53 Arg72Pro is significantly associated with the increased risks of digestive tract cancers, especially for Asians, and for gastric cancer, colorectal cancer and gallbladder and pancreatic cancer.
|
21376265 |
2011 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that TP53 rs1042522 polymorphism might contribute to the susceptibility of gastric cancer under the dominant model, especially in Eastern Asians.
|
24534481 |
2014 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The purpose of the present hospital-based case-control study was to investigate the association between the miR-34b/c rs4938723 and TP53 Arg72Pro polymorphisms and the risk of gastric cancer.
|
25190020 |
2014 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests the Pro variant of TP53 Arg72Pro contributes to gastric cancer risk in Asians.
|
22631671 |
2012 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the case-control study, rs1042522 (<i>TP53</i>) was associated with a stronger risk for developing gastric cancer in the sample stratified for diffuse subtype patients when compared to the risk observed for the total cases; CTC haplotype (rs699947/rs833061/rs2010963 <i>VEGFA</i>) was associated with risk while rs699947 was associated with protection for gastric malignancy in the total sample.
|
30551681 |
2018 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To clarify any association between the hOGG1 Ser326Cys polymorphism and susceptibility to gastric cancer.
|
22799296 |
2012 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our result could explain the association between hOGG1 Ser326Cys polymorphism and GC risk.
|
22294108 |
2012 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Lack of association between the hOGG1 gene Ser326Cys polymorphism and gastric cancer risk: evidence from a case-control study and a meta-analysis.
|
26600527 |
2015 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the association between genetic polymorphisms of X-ray repair cross-complementing group 1 (XRCC1, Arg194Trp and Arg399Gln), adenosine diphosphate ribosyl transferase (ADPRT, Val762Ala), 8-oxoguanine DNA glycosylase (OGG1, Ser326Cys) and apurinic/apyrimidinic endonuclease 1 (APE1, Asp148Glu) and evolution of H.pylori-associated precancerous gastric lesions, a population-based cohort study was conducted in Linqu County, a high-risk area of gastric cancer in China.
|
19147860 |
2009 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
hOGG1 Ser326Cys polymorphism, interaction with environmental exposures, and gastric cancer risk in Japanese populations.
|
15596047 |
2004 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To investigate the association between Ser326Cys human oxoguanine glycosylase 1 (hOGG1) polymorphism and atrophic gastritis and gastric cancer after Helicobacter pylori (H. pylori) eradication.
|
20845517 |
2010 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No significant association was found for either allele or genotype with gastric cancer (odds ratio [OR]=0.96; 95% confidence interval [95% CI]: 0.82-1.13; P=0.66), and this was also the case after combining 326Ser/Cys and 326Ser/Ser genotypes together (OR=0.87; 95% CI: 0.63-1.20; P=0.40), or 326Cys/Cys and 326Ser/Cys together (OR=1.03; 95% CI: 0.87-1.22; P=0.72).
|
22471492 |
2011 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Taken together, the results suggest that the hOGG1 Ser326Cys polymorphism may contribute to susceptibility to gastric cancer.
|
22343785 |
2012 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphic variants of base excision repair (APE1-D148E, XRCC1-R194W, XRCC1-R399Q and OGG1-S326C), nucleotide excision repair (XPC-PAT, XPA-23G>A, ERCC1-19007T>C and XPD-L751Q), recombination (XRCC3-T241M) and alkylation damage reversal (MGMT-L84F) were tested for their potential role in the development of GC by using logistic regression models.
|
20817763 |
2010 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The significant effects of hOGG1 Ser326Cys polymorphism on colorectal, breast, bladder, prostate, esophageal, and gastric cancer were not detected.
|
22114677 |
2011 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis showed there was no association between hOGG1 rs1052133 and GC.
|
28415729 |
2017 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We examined the distribution of the hOGG1 Ser326Cys polymorphism and its presumed correlation with gastric cancer risk in two case-control studies of different ethnic groups in São Paulo, Brazil.
|
11448535 |
2001 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although smokers and high salted tea drinkers themselves were at higher risk for gastric cancer (OR=8.975, P=0.0001; OR=14.778, P=0.0001), interaction with OGG1 Ser326Cys did not further modulate the risk.
|
20593951 |
2010 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This variant decreased the gene promoter activity by approximately 17.8% (P = 0.041) and exhibited a synergistic effect with the missense mutation p.Ser326Cys of hOGG1 by enhancing susceptibility to gastric cancers.
|
21822670 |
2011 |
|
rs1052133
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis provided evidence that hOGG1 S326C genetic polymorphism was not associated with increased risk of gastric cancer.
|
22296498 |
2012 |