|
rs1892901
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings indicated that functional SNP rs1892901 in FOSL1 might affect the expression of FOSL1, and ultimately increase the risk of gastric cancer.
|
28169308 |
2017 |
|
rs1924966
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two novel variants, rs1924966 and rs115797771, were associated with ESCC risk (P = 1.37 × 10(-10) and P = 2.32 × 10(-10), respectively) and were also associated with risk of gastric cardia cancer (P = 0.0003 and P = 0.0018, respectively) but not gastric cancer and colorectal cancer.
|
26315552 |
2015 |
|
rs2178146
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results confirmed that rs2689154 in MIPEPP2 was significantly decreased GC risk, but rs12615966 in LOC284998 was significantly increased GC risk, and rs2178146 in FOXF1 was associated with increased CRC risk in the Han Chinese population.
|
28404937 |
2017 |
|
rs26160
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, none of the four polymorphisms or their haplotypes achieved significant differences in their distributions between gastric cancer cases and controls, and interestingly, in the subgroup analysis of gastric cancer, we found that CA genotype of rs26160 and CG genotype of rs17690554 were associated with the risk of diffuse gastric cancer, compared with their wild genotypes (OR = 2.98, 95 % CI: 1.60-5.53; OR = 2.10, 95 % CI: 1.14-3.85, respectively, P < 0.05).
|
22535324 |
2012 |
|
rs2689154
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, genetic model analyses showed that rs2689154 was associated with a reduced risk of GC under the recessive model (adjusted OR = 0.46, 95% CI: 0.22-0.98, P = 0.037), and rs12615966 in FOXF1 was associated with an increased risk of GC in both the dominant and log-additive models after adjusted for age and gender (adjusted OR = 1.36, 95% CI: 1.02-1.81, P = 0.033; adjusted OR = 1.36, 95% CI: 1.05-1.75, P = 0.018, respectively).
|
28404937 |
2017 |
|
rs398652
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, RTL-related rs621559 and rs398652 genetic variants are significantly associated with GC risk.
|
27797826 |
2017 |
|
rs4145643
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CDK1 rs4145643, FAS rs6586161, and FAS rs1468063 in the AKT signaling pathway presented significant genetic effects on gastric cancer (OR = 0.81 (95% CI: 0.66-0.99) for CDK1 rs4145643; OR = 1.27 (95% CI: 1.03-1.58) for FAS rs6586161; OR = 1.29 (95% CI: 1.03-1.56) for FAS rs1468063; Cochran Q statistics > 0.10).
|
23042672 |
2012 |
|
rs4733616
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study suggests that the SNP rs4733616 is associated with susceptibility to poorly differentiated gastric cancer in Venezuelans.
|
25939847 |
2015 |
|
rs4912913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, we made a joint effect analysis of rs12521436, rs33388 and rs4912913 on risk of gastric cancer (<i>P<sub>Trend</sub></i> =2.83×10<sup>-5</sup>).
|
29285253 |
2017 |
|
rs917997
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among 11 candidate single nucleotide polymorphisms (SNPs), subjects carrying IL-18RAP rs917997 AA genotype were associated with risk of GC [adjusted odds ratio (OR) = 1.83, 95 % confidence interval (CI) 1.14-2.92] or chronic atrophic gastritis (CAG; OR = 1.55, 95 % CI 1.07-2.24).
|
26358252 |
2016 |
|
rs9502893
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, a shared susceptibility locus rs9502893 was found to have significant protective effect against CRC (p = 0.010; OR = 0.80) and GC (p = 0.0003; OR = 0.74).
|
26383524 |
2016 |
|
rs9564966
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggested that the rs9564966 G > A polymorphism may be a potential biomarker to predict the survival of Chinese patients with GC.
|
30537204 |
2019 |
|
rs9981660
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, we found that TFF2 rs3814896 AG+GG genotypes in people aged ≤ 50 years and TFF3 rs9981660 AG+AA genotypes in younger males with diffuse-type GC were associated with higher levels of TFF2 and TFF3 mRNA respectively.
|
23933418 |
2013 |
|
rs1045642
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In this preliminary data, the association with MDR1 C3435T polymorphism and risk for developing H. pylori-related gastric cancer and peptic ulcer in Japanese was low.
|
18644389 |
2008 |
|
rs1045642
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Generally, indels rs34743033 and rs16430 were genotyped by PCR and polyacrylamide gel electrophoresis assay and SNPs rs2032582 and rs1045642 were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay in 110 Chinese AGC patients post-chemotherapy.
|
28074308 |
2017 |
|
rs1045642
|
|
|
0.040 |
GeneticVariation |
BEFREE |
This meta-analysis suggested that the MDR1 C3435T polymorphism is not associated with susceptibility to GC and PU.
|
24815441 |
2014 |
|
rs1045642
|
|
|
0.040 |
GeneticVariation |
BEFREE |
No correlation was observed between the C3435T polymorphism of the MDR1 gene and GC risk or prognosis in the population studied.
|
22641402 |
2012 |
|
rs2032582
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate the impacts of gene variations on survival outcomes of advanced gastric cancer (AGC) patients treated with 5‑fluorouracil (5-FU)-based chemotherapy, we analyzed the associations of 2 indels of the TS gene rs34743033 (double or triple tandem repeats of a 28 bp sequence in 5'-UTR, denoted as 2R or 3R allele) and rs16430 (a 6 bp variation at 1494 bp in 3'-UTR, denoted as ins6 or del6 allele) and 2 single nucleotide polymorphisms (SNPs) of ABCB1gene rs2032582 in exon 21 and rs1045642 in exon 26, with clinical outcomes after 5‑FU treatment.
|
28074308 |
2017 |
|
rs1305398818
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To study the possible mechanisms of S100P enhanced the chemosensitivity to oxaliplatin in gastric cancer cell lines.
|
23736016 |
2013 |
|
rs505922
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four variants (including rs505922) in ABO, and allelic blood group A (AO+AA, odds ratio=1.84, 95%CI=1.20-2.80) were associated with diffuse-type GC; however, conditional models with other ABO variants indicated that the associations were largely due to allelic blood group A.
|
24947433 |
2015 |
|
rs6586161
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CDK1 rs4145643, FAS rs6586161, and FAS rs1468063 in the AKT signaling pathway presented significant genetic effects on gastric cancer (OR = 0.81 (95% CI: 0.66-0.99) for CDK1 rs4145643; OR = 1.27 (95% CI: 1.03-1.58) for FAS rs6586161; OR = 1.29 (95% CI: 1.03-1.56) for FAS rs1468063; Cochran Q statistics > 0.10).
|
23042672 |
2012 |
|
rs11896604
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Under additive model and recessive model, rs11125529, rs12615793, rs843711, rs11896604, and rs17045754 also activated the risk of GC (P < 0.05).
|
28415712 |
2017 |
|
rs6713088
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the minor alleles of rs6713088, rs11125529, rs12615793, rs843711, rs11896604, rs843706 and rs17045754 significantly stimulated the risk of GC, and homozygous alleles of above SNPs except rs6713088 were also found increasing the GC risk (P < 0.05).
|
28415712 |
2017 |
|
rs17045754
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Under additive model and recessive model, rs11125529, rs12615793, rs843711, rs11896604, and rs17045754 also activated the risk of GC (P < 0.05).
|
28415712 |
2017 |
|
rs843706
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further results of haplotype analysis founds that the haplotypes "TTCTAATG" (rs1682111, rs843752, rs10439478, rs843645, rs11125529, rs12615793, rs843711, and rs11896604) and "AC" (rs843706 and rs17045754) were more frequency among patients with GC, on the contrary, the haplotypes "CG" had a protective role in the GC risk (P < 0.05).
|
28415712 |
2017 |