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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Second, MTHFR C677T polymorphism, which affects the blood homocysteine levels, was used as an instrumental variable to calculate the risk and estimate the association of gastric cancer with this single nucleotide polymorphism (SNP).
|
27196483 |
2016 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
5-fluorouracil (5-Fu) metabolism associated enzyme, methylenetetrahydrofolate reductase (MTHFR)'s polymorphism C677T can affect enzyme activity and a series of studies have been performed to examine the association of this MTHFR polymorphism with the clinical outcomes of gastric cancer (GC) patients treated with 5-Fu based chemotherapies.
|
29581785 |
2018 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis supports an association between the MTHFR C677T polymorphism and increased risk of esophageal and stom</span>ach cancer, especially among Asians.
|
24744129 |
2014 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
However, in meta-analyses odds ratio for MTHFR c.677C>T homozygotes versus noncarriers were 1.07 (95% CI: 1.01-1.12) for any cancer, 1.77 (1.17-2.68) for esophagus cancer, 1.40 (1.19-1.66) for gastric cancer and 0.85 (0.77-0.94) for colorectal cancer.
|
20473868 |
2011 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
These results suggest that the MTHFR C677T and A1298C polymorphisms by themselves do not play an important role in the etiology of stomach cancer in the Korean population.
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16158971 |
2005 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Overall, the ORs under five contrast models indicated that the MTHFR C6</span>77T variant was positively associated with gastric cancer risk (ORT vs. C = 1.21, 95% CI 1.10–1.34, P(OR) < 0.001; OR(TT vs. CC) = 1.47, 95% CI 1.22–1.76, P(OR) < 0.001; OR(TC vs. CC) = 1.20, 95% CI 1.03-1.40, P(OR) = 0.022; OR(TT + TC vs. CC) = 1.27, 95% CI 1.10-1.47, P(OR) = 0.001; OR(TT vs. CC + TC) = 1.29, 95% CI 1.15-1.46, P(OR) < 0.001).
|
24122207 |
2014 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
The authors performed a meta-analysis and individual data pooled analysis of case-control studies that examined the association between C677T and A1298C polymorphisms (the former being associated with low folate serum levels) and gastric cancer (meta-analyses: 16 studies, 2,727 cases and 4,640 controls for C677T and seven studies, 1,223 cases and 2,015 controls for A1298C; pooled analyses: nine studies, 1,540 cases and 2,577 controls for C677T and five studies, 1,146 cases and 1,549 controls for A1298C).
|
18162478 |
2008 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Recently, methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) mutations were discovered to be associated with childhood acute lymphoblastic leukemia (ALL), as well as colon cancer, lymphoma, esophageal and stomach cancer.
|
16886608 |
2006 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The MTHFR C677T frequencies of CC, CT, and TT genotypes were 35.2%, 47.5%, and 17.3% among stomach cancer, 34%, 50.5%, and 15.5% in colorectal cancer, and 31.8%, 50.7%, and 17.5% in the controls, respectively.
|
20504332 |
2010 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
C677T, A1298C and G1793A) and their haplotypes are associated with the risk of gastric cancer.
|
15643524 |
2005 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
Decrease in gastric cancer susceptibility by MTHFR C677T polymorphism in Ardabil Province, Iran.
|
23934457 |
2013 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest that the MTHFR C677T and MTHFR A1298C polymorphisms are related to gastric cancer susceptibility in the Chinese population.
|
24737431 |
2014 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
We found that the MTHFR C677T polymorphism was associated with colorectal cancer (P<0.04) but not with gastric cancer.
|
27823653 |
2016 |
|
rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
The MTHFR C677T polymorphism was demonstrated to significantly increase the susceptibility to gastric cancer (OR(T vs. C) = 1.21, 95% CI 1.10-1.34; OR(TT vs. CC )= 1.47, 95% CI 1.22-1.76; OR(TC vs. CC )= 1.20, 95% CI 1.03-1.40; OR(TT + TC vs. CC) = 1.27, 95% CI 1.10-1.47; OR(TT vs. CC + TC )= 1.29, 95% CI 1.15-1.46), whereas no significant correlation was observed when assessing the MTHFR A1298C polymorphism (OR(C vs. A )= 1.00, 95% CI 0.90-1.10; OR(CC vs. AA) = 0.99, 95% CI 0.75-1.31; OR(CA vs. AA )= 1.01, 95% CI 0.89-1.14; OR(CC + CA vs. AA) = 1.00, 95% CI 0.89-1.13; OR(CC vs. AA + CA) = 0.97, 95% CI 0.74-1.27).
|
23897558 |
2014 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T polymorphism and differential methylation status in gastric cancer: an association with Helicobacter pylori infection.
|
20957490 |
2010 |
|
rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
The evidence from our meta-analysis supports that TT genotype of MTHFR C677T polymorphism contributes to susceptibility to gastric cancer, but no significant association was detected for CC genotype of MTHFR A1298C.
|
20470942 |
2010 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
We performed a case-control study to examine the relationship between MTHFR C677T gene polymorphism (MTHFR677C/T) and gastric cancer susceptibility in at-risk populations in central Italy.
|
16094648 |
2006 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Assuming a very low prior probability of 0.000001, similar to a probability assumed for a randomly selected single-nucleotide polymorphism in a genome-wide association study, and statistical power to detect an OR of 1.5, 4 associations were considered noteworthy as denoted by an FPRP value <0.2: GSTM1 null and bladder cancer (OR, 1.5; 95% CI, 1.3-1.6; P = 1.9 x 10(-14)), NAT2 slow acetylator and bladder cancer (OR, 1.46; 95% CI, 1.26-1.68; P = 2.5 x 10(-7)), MTHFR C677T and gastric cancer (OR, 1.52; 95% CI, 1.31-1.77; P = 4.9 x 10(-8)), and GSTM1 null and acute leukemia (OR, 1.20; 95% CI, 1.14-1.25; P = 8.6 x 10(-15)).
|
18505952 |
2008 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
To clarify the influence of MTHFR C677T and A1298C polymorphisms on ga</span>stric cancer (GC), a meta-analysis of eight case-control studies (1,584/2,785 cases/controls) was carried out.
|
16758123 |
2006 |
|
rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T polymorphism is a risk factor for GC, and the A1298C polymorphism may be a protective factor against GC in eastern populations.
|
25170232 |
2014 |
|
rs1799782
|
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|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis aimed to summarize published data about the association between two SNPs of XRCC1 (Arg194Trp and Arg399Gln) and treatment outcomes of patients with advanced gastric cancer.
|
24465544 |
2014 |
|
rs1799782
|
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|
0.100 |
GeneticVariation |
BEFREE |
Our findings demonstrated that the genetic variant Arg280His in XRCC1 may contribute to cancer progression and that XRCC1 Arg194Trp variants may act as a favorable prognostic indicator of resected GC, particularly among the diffuse-type GC.
|
23425027 |
2013 |
|
rs1799782
|
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|
0.100 |
GeneticVariation |
BEFREE |
However, significant associations between Arg194Trp polymorphism and gastric cancer were found in Asian.
|
25335737 |
2014 |
|
rs1799782
|
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|
0.100 |
GeneticVariation |
BEFREE |
Polymorphic variants of base excision repair (APE1-D148E, XRCC1-R194W, XRCC1-R399Q and OGG1-S326C), nucleotide excision repair (XPC-PAT, XPA-23G>A, ERCC1-19007T>C and XPD-L751Q), recombination (XRCC3-T241M) and alkylation damage reversal (MGMT-L84F) were tested for their potential role in the development of GC by using logistic regression models.
|
20817763 |
2010 |
|
rs1799782
|
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|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the association between genetic polymorphisms of X-ray repair cross-complementing group 1 (XRCC1, Arg194Trp and Arg399Gln), adenosine diphosphate ribosyl transferase (ADPRT, Val762Ala), 8-oxoguanine DNA glycosylase (OGG1, Ser326Cys) and apurinic/apyrimidinic endonuclease 1 (APE1, Asp148Glu) and evolution of H.pylori-associated precancerous gastric lesions, a population-based cohort study was conducted in Linqu County, a high-risk area of gastric cancer in China.
|
19147860 |
2009 |