| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
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0.070 | GeneticVariation | BEFREE | Asp299Gly and Thr399Ile polymorphisms in TLR4 have been associated with a variety of inflammatory and infectious conditions including gastric cancer. | 24295404 | 2014 |
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0.070 | GeneticVariation | BEFREE | To investigate toll-like receptor 2 (TLR2) -196 to -174 del, and TLR4 (+896A/G rs4986790 and +1196C/T rs4986791) polymorphisms at risk of chronic gastritis and gastric cancer in a Brazilian population and association of gastric lesions with risk factors such as smoking, alcohol intake and Helicobacter pylori infection. | 22468087 | 2012 |
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0.070 | GeneticVariation | BEFREE | It seems to be that Asp299Gly and Thr399Ile are related to increased risk of precancerous gastric lesions, and, possibly, gastric cancer. | 21081146 | 2011 |
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0.070 | GeneticVariation | BEFREE | Our results demonstrated that TLR-4 Thr399Ile polymorphism is linked with an increased susceptibility to gastric cancer. | 18826495 | 2008 |
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0.070 | GeneticVariation | BEFREE | TLR4/D299G/T399I polymorphisms were more frequent in duodenal ulcer and showed a trend in gastric cancer, when compared with non-atrophic gastritis. | 18755634 | 2008 |
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0.070 | GeneticVariation | BEFREE | The host response to H. pylori has been related to genetic polymorphisms that influence both innate and adaptive immune responses.Our aim was to investigate whether the presence of the TLR4 Asp299Gly, TLR4 Thr399Ile and IL-8-251 A/T polymorphisms had any influence in the development of distal GC in a Mexican population. | 17462092 | 2007 |
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0.070 | GeneticVariation | BEFREE | We investigated the effects of common polymorphisms of TLR4 Asp299Gly, Thr399Ile and CD14 promoter -C159T on the risk of gastric cancer including its subtypes and clinicopathologic features. | 19847953 | 2007 |