|
rs763780
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129).
|
31516756 |
2019 |
|
rs763780
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The pooled estimate revealed an association between IL-17A rs2275913 polymorphism and the risk of GC under all genetic models (A vs. G, OR 1.187, 95% CI 1.086-1.297, P < 0.001; GA vs. GG, OR 1.108, 95% CI 1.008-1.218, P = 0.033; AA vs. GG, OR 1.484, 95% CI 1.236-1.781, P < 0.001), while no evidence of association was found with IL-17A rs3748067 or IL-17F rs763780 polymorphisms.
|
29860554 |
2018 |
|
rs763780
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conducted a case-control study to investigate the role of interleukin-17A (IL-17A) rs2275913 G > A and IL-17F rs763780 T > C polymorphisms in the development of gastric cancer.
|
27525907 |
2016 |
|
rs763780
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Subgroup analysis by country revealed that the rs2275913 G>A and rs763780 T>C polymorphisms may be the main risk factor for gastric cancer in Chinese and Japanese populations.
|
25987798 |
2015 |
|
rs763780
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, our results suggest that the IL-17A rs3748067C>T and IL-17F rs763780 T>C polymorphisms play an important role in the risk of gastric cancer in a Chinese population.
|
26535650 |
2015 |
|
rs763780
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Subgroup analysis showed that rs2275913 GG (OR = 1.35, 95%CI = 1.05-1.73) and rs763780 TC (OR= 1.44, 95%CI = 1.20-1.75) genotypes were not significantly associated with increased risk of gastric cancer in Japanese populations.
|
26125910 |
2015 |
|
rs763780
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, IL-17A rs2275913 A/G polymorphism and IL-17F rs763780 C/T polymorphism might be associated with increased GC risk in Asians.
|
25500254 |
2015 |
|
rs763780
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta analysis reveal the IL-17A rs763780T>C gene polymorphism is involved in risk of gastric cancer but not other tumor types.
|
25338988 |
2014 |
|
rs763780
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs2275913G>A and rs763780T>C polymorphisms increase gastric cancer risk, and interact with H. pylori infection and subsites.
|
24218334 |
2014 |
|
rs763780
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, no significant positive signals were observed in the association analysis of the rs3748067 and rs763780 polymorphisms with the risk of gastric cancer in IL-17A and IL-17F, respectively.
|
25374195 |
2014 |