Gene: MAP2K1 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057519730
rs1057519730
MAP2K1
G 0.700 CausalMutation CLINVAR Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors. 22588879

2012
dbSNP: rs1057519732
rs1057519732
MAP2K1
T 0.700 CausalMutation CLINVAR MEK1 mutations confer resistance to MEK and B-RAF inhibition. 19915144

2009
dbSNP: rs1057519732
rs1057519732
MAP2K1
T 0.700 CausalMutation CLINVAR Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors. 22588879

2012
dbSNP: rs1057519732
rs1057519732
MAP2K1
T 0.700 CausalMutation CLINVAR Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. 22197931

2011
dbSNP: rs1057519733
rs1057519733
MAP2K1
A 0.700 CausalMutation CLINVAR MEK1 mutations confer resistance to MEK and B-RAF inhibition. 19915144

2009
dbSNP: rs1057519733
rs1057519733
MAP2K1
A 0.700 CausalMutation CLINVAR Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma. 23569304

2013
dbSNP: rs1057519733
rs1057519733
MAP2K1
A 0.700 CausalMutation CLINVAR Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. 22197931

2011
dbSNP: rs1057519734
rs1057519734
MAP2K1
T 0.700 CausalMutation CLINVAR Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. 22197931

2011
dbSNP: rs1057519734
rs1057519734
MAP2K1
T 0.700 CausalMutation CLINVAR Melanoma genome sequencing reveals frequent PREX2 mutations. 22622578

2012
dbSNP: rs1057519735
rs1057519735
MAP2K1 ; SNAPC5
C 0.700 CausalMutation CLINVAR Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. 22197931

2011