rs401681
|
|
|
0.860 |
GeneticVariation |
BEFREE |
In a multivariable model that included only the most statistically significant findings from univariable modeling and adjusted for pigmentary phenotype, back nevi, and baseline features, we found TERT/CLPTM1L rs401681 (P = 0.004), TYRP1 rs2733832 (P = 0.006), MTAP rs1335510 (P = 0.0005), TYR rs10830253 (P = 0.003), and MX2 rs45430 (P = 0.008) to be significantly associated with multiple primary melanoma, while NCOA6 rs4911442 approached significance (P = 0.06).
|
25837821 |
2015 |
rs401681
|
|
|
0.860 |
GeneticVariation |
BEFREE |
In the melanoma dataset, two pancreatic cancer susceptibility variants were associated: NR5A2 (rs12029406; OR, 1.39; 95% CI, 1.01-1.92; P = 0.04) and CLPTM1L-TERT (rs401681; OR, 1.16; 95% CI, 1.01-1.34; P = 0.04).
|
24642353 |
2014 |
rs401681
|
|
|
0.860 |
GeneticVariation |
BEFREE |
We also obtained significant results when we tested the association between rs401681 variant (TERT-CLPTM1L locus) with melanoma risk (Odds ratio, OR; 95% confidence interval, CI=1.24 (1.08-1.43); p-value, 3×10(-3)).
|
25457634 |
2014 |
rs401681
|
|
|
0.860 |
GeneticVariation |
BEFREE |
These findings suggested that rs401681 C allele was a low-penetrance risk allele for the development of cancers of lung, bladder, prostate and basal cell carcinoma, but a potential protective allele for melanoma and pancreatic cancer.
|
23226346 |
2012 |
rs401681
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Also, the SNP rs401681 in the TERT-CLPTM1L locus was replicated for the association with melanoma risk.
|
21116649 |
2011 |
rs401681
|
|
A |
0.860 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies three new melanoma susceptibility loci.
|
21983787 |
2011 |
rs401681
|
|
A |
0.860 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies three new melanoma susceptibility loci.
|
21983787 |
2011 |
rs401681
|
|
|
0.860 |
GeneticVariation |
BEFREE |
We evaluated the association between single nucleotide polymorphism (SNP) rs401681 (C > T) and mean telomere length, using quantitative real-time PCR, in blood-extracted DNA collected from 11,314 cancer-free participants from the Sisters in Breast Screening study, the Melanoma and Pigmented Lesions Evaluative Study melanoma family study, and the SEARCH Breast, Colorectal, Melanoma studies.
|
20570912 |
2010 |
rs45430
|
|
|
0.820 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (SNP), rs45430, in an intron of the MX2 gene, was previously reported as a novel melanoma susceptibility locus in genome-wide association studies.
|
31660681 |
2019 |
rs45430
|
|
T |
0.820 |
GeneticVariation |
GWASCAT |
Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma.
|
28212542 |
2017 |
rs45430
|
|
|
0.820 |
GeneticVariation |
BEFREE |
In a multivariable model that included only the most statistically significant findings from univariable modeling and adjusted for pigmentary phenotype, back nevi, and baseline features, we found TERT/CLPTM1L rs401681 (P = 0.004), TYRP1 rs2733832 (P = 0.006), MTAP rs1335510 (P = 0.0005), TYR rs10830253 (P = 0.003), and MX2 rs45430 (P = 0.008) to be significantly associated with multiple primary melanoma, while NCOA6 rs4911442 approached significance (P = 0.06).
|
25837821 |
2015 |
rs3219090
|
|
|
0.820 |
GeneticVariation |
BEFREE |
We confirmed the proposed role of rs3219090, located on the PARP1 gene, and rs12203592, located on the IRF4 gene, as protective to MM along the same lines as have previous genome-wide associated works.
|
23537197 |
2013 |
rs3219090
|
|
|
0.820 |
GeneticVariation |
BEFREE |
We also show evidence suggesting that melanoma associates with 1q42.12 (rs3219090, P = 9.3 × 10(-8)).
|
21983785 |
2011 |
rs3219090
|
|
C |
0.820 |
GeneticVariation |
GWASDB |
We also show evidence suggesting that melanoma associates with 1q42.12 (rs3219090, P = 9.3 × 10(-8)).
|
21983785 |
2011 |
rs3219090
|
|
C |
0.820 |
GeneticVariation |
GWASCAT |
We also show evidence suggesting that melanoma associates with 1q42.12 (rs3219090, P = 9.3 × 10(-8)).
|
21983785 |
2011 |
rs45430
|
|
|
0.820 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies three new melanoma susceptibility loci.
|
21983787 |
2011 |
rs45430
|
|
|
0.820 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies three new melanoma susceptibility loci.
|
21983787 |
2011 |
rs1801516
|
|
|
0.810 |
GeneticVariation |
GWASCAT |
Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma.
|
28212542 |
2017 |
rs7023329
|
|
|
0.810 |
GeneticVariation |
GWASCAT |
Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma.
|
28212542 |
2017 |
rs910873
|
|
A |
0.810 |
GeneticVariation |
GWASCAT |
Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma.
|
28212542 |
2017 |
rs17119461
|
|
|
0.810 |
GeneticVariation |
BEFREE |
In the PanScan data, initial associations were found with melanoma susceptibility variants in NCOA6 [rs4911442; OR, 1.32; 95% confidence interval (CI), 1.03-1.70; P = 0.03], YWHAZP5 (rs17119461; OR, 2.62; 95% CI, 1.08-6.35; P = 0.03), and YWHAZP5 (rs17119490; OR, 2.62; 95% CI, 1.08-6.34; P = 0.03), TYRP1 (P = 0.04), and IFNA13 (P = 0.04).
|
24642353 |
2014 |
rs4698934
|
|
|
0.810 |
GeneticVariation |
BEFREE |
The SNP rs4698934 was nominally significantly associated with melanoma risk.
|
24980573 |
2014 |
rs4698934
|
|
|
0.810 |
GeneticVariation |
GWASDB |
The SNP rs4698934 was nominally significantly associated with melanoma risk.
|
24980573 |
2014 |
rs4698934
|
|
|
0.810 |
GeneticVariation |
GWASCAT |
The SNP rs4698934 was nominally significantly associated with melanoma risk.
|
24980573 |
2014 |
rs1801516
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Finally, rs1801516, located on the ATM gene, showed a trend towards a protective role in MM similar to the one firstly described in a GWAS study.
|
23537197 |
2013 |