|
rs738409
|
|
|
0.040 |
GeneticVariation |
BEFREE |
I148M variant of PNPLA3 increases the susceptibility to non-alcoholic fatty liver disease caused by obesity and metabolic disorders.
|
26765961 |
2016 |
|
rs738409
|
|
|
0.040 |
GeneticVariation |
BEFREE |
I148M variant in PNPLA3 reduces central adiposity and metabolic disease risks while increasing nonalcoholic fatty liver disease.
|
26148225 |
2015 |
|
rs738409
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In Inter99, we analyzed associations of rs738409 with components of the WHO-defined metabolic syndrome (n = 5,847) and traits related to metabolic disease (n = 5,663).
|
22792295 |
2012 |
|
rs738409
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The lack of a relationship with visceral obesity and the inverse correlation with CIMT suggest that fatty liver associated with the minor G allele of the PNPLA3 rs738409 polymorphism may not be linked to metabolic disorders.
|
20826584 |
2010 |
|
rs854560
|
|
|
0.020 |
GeneticVariation |
BEFREE |
L55M polymorphism, like exposure to tobacco smoke and overweight, disorders PON1 status and lipid profile parameters; therefore, it could be a crucial risk factor for the development of many metabolic disorders.
|
30618305 |
2019 |
|
rs8192678
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Linking Metabolic Disease With the PGC-1α Gly482Ser Polymorphism.
|
29186342 |
2018 |
|
rs2059806
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Thus, it was found that the INSR rs2059806 SNP is also associated with pre-eclampsia phenotypes in two independent cohorts suggesting that genetic susceptibility may be implicated in the link between pre-eclampsia and subsequent vascular and metabolic diseases.
|
28117222 |
2017 |
|
rs4994
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The aim of this study was to determine the relationship between PPAR gamma-2 (Pro12Ala, C1431T) and ADRB3 (Trp64Arg) polymorphisms and serum adipocytokines (adiponectin, visfatin, and resistin) and metabolic disorders in 176 postmenopausal women with increased body mass (BMI ≥ 25 kg m(-2)).
|
27246401 |
2016 |
|
rs2059806
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The INSR rs2059806 SNP previously associated with adult vascular and metabolic diseases is also associated with SGA pregnancies.
|
26089371 |
2015 |
|
rs1801282
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Thus, PPARγ2 rs1801282 polymorphism may play a significant role in the development of metabolic disorders in HIV/HCV coinfected patients, and might have an influence on the cardiovascular risk.
|
25159899 |
2014 |
|
rs854560
|
|
|
0.020 |
GeneticVariation |
BEFREE |
None of the variants of the Leu55Met PON1 polymorphism was associated with more frequent occurrence of PCOS or metabolic disorders, including insulin resistance.
|
20334584 |
2010 |
|
rs1801282
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the PPARG Pro12Ala polymorphism might represent a genetic susceptibility factor for preterm birth and constitute a link between preterm birth and metabolic diseases later in life.
|
17259396 |
2007 |
|
rs8192678
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our findings confirm that sex and age should be considered when investigating the influence of the PPARGC1A Gly482Ser polymorphism on metabolic disease.
|
16474966 |
2006 |
|
rs4994
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results suggest that the Trp64Arg mutation is not a major determinant of metabolic disorders (type 2 diabetes, obesity) and chronic complications of type 2 diabetes in a Dutch population.
|
11213599 |
2001 |
|
rs10830963
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study found that MTNR1A rs2119882 and MTNR1B rs10830963 could increase the risk for PCOS and cause glycolipid metabolism disorder in PCOS patients.
|
30664204 |
2019 |
|
rs182052
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, the results indicate that minor A allele of rs182052 of the <i>ADIPOQ</i> gene is significantly associated with a decrease in serum adiponectin levels, and two SNPs (rs182052 and rs266729) of the <i>ADIPOQ</i> gene are significantly associated with cardiovascular and metabolic diseases.
|
31561637 |
2019 |
|
rs2119882
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study found that MTNR1A rs2119882 and MTNR1B rs10830963 could increase the risk for PCOS and cause glycolipid metabolism disorder in PCOS patients.
|
30664204 |
2019 |
|
rs2331841
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data first suggest that SNPs in the rs2331841 site of the <i>MC4R</i> gene are closely related to obesity and its related metabolic disorders in Chinese Northern Han populations.
|
31781208 |
2019 |
|
rs266729
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, the results indicate that minor A allele of rs182052 of the <i>ADIPOQ</i> gene is significantly associated with a decrease in serum adiponectin levels, and two SNPs (rs182052 and rs266729) of the <i>ADIPOQ</i> gene are significantly associated with cardiovascular and metabolic diseases.
|
31561637 |
2019 |
|
rs1799883
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to determine whether FABP2 (Ala54Thr) and MTTP (-493 G/T) genetic polymorphisms are associated with metabolic disorders in Mexican subjects.
|
29338565 |
2018 |
|
rs6265
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Plasma BDNF levels and a functional <i>BDNF</i> Val66Met (rs6265) polymorphism were reported to be associated with PTSD, as well as with increased body mass index (BMI) and dyslipidaemia in healthy subjects and patients with cardio-metabolic diseases, but these results are controversial.
|
30542302 |
2018 |
|
rs9939609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No direct relationships were demonstrated between MetS and the gene polymorphisms analyzed in our study except for the <i>FTO</i> rs9939609, whose A allele and A/A genotype seemed to predispose to metabolic disorders.
|
30271660 |
2018 |
|
rs1267969615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of the study was to investigate the association between ACE (I/D) and AGT (M235T) gene polymorphisms and cardiovascular and metabolic disorders in the acromegaly.
|
28712073 |
2017 |
|
rs150924946
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, this study also correlated novel variant p.K108E with psychiatric disease, identified known variant p.I299V as a potential risk factor for metabolic disease in Latinos, linked variant p.G602 with type 2 diabetes, and identified p.G602S as a predictor of diabetes risk in African Americans.
|
28663758 |
2017 |
|
rs16139
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A gain-of-function polymorphism in human neuropeptide Y (<i>NPY</i>) gene (rs16139) associates with metabolic disorders and earlier onset of type 2 diabetes (T2D).
|
28468933 |
2017 |