Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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|
0.720 | GeneticVariation | BEFREE | Application of the Movement Disorder Society prodromal criteria in healthy G2019S-LRRK2 carriers. | 29603409 | 2018 |
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|
A | 0.720 | CausalMutation | CLINVAR | Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling. | 28103901 | 2017 |
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|
A | 0.720 | CausalMutation | CLINVAR | Disease penetrance of late-onset parkinsonism: a meta-analysis. | 25330418 | 2014 |
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|
A | 0.720 | CausalMutation | CLINVAR | Parkinson disease phenotype in Ashkenazi Jews with and without LRRK2 G2019S mutations. | 24243757 | 2013 |
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|
A | 0.720 | CausalMutation | CLINVAR | Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls. | 18213618 | 2008 |
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|
A | 0.720 | CausalMutation | CLINVAR | Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity. | 17200152 | 2007 |
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|
0.720 | GeneticVariation | BEFREE | The objective of this study was to assess performance characteristics of G2019S as a clinical test for PD in the setting of typical movement disorder clinics in the United States. | 17020475 | 2006 |
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|
A | 0.720 | CausalMutation | CLINVAR | LRRK2 gene in Parkinson disease: mutation analysis and case control association study. | 16157901 | 2005 |
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|
A | 0.720 | CausalMutation | CLINVAR | Clinical traits of LRRK2-associated Parkinson's disease in Ireland: a link between familial and idiopathic PD. | 16102999 | 2005 |
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|
A | 0.720 | CausalMutation | CLINVAR | Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. | 15541309 | 2004 |