rs28493229
|
|
|
0.890 |
GeneticVariation |
BEFREE |
SNP rs28493229 in ITPKC was associated with KD and coronary artery complications.
|
29214786 |
2018 |
rs28493229
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Functional single-nucleotide polymorphisms (SNPs) in inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) (rs28493229) and caspase-3 (CASP3) (rs113420705; formerly rs72689236) are associated with susceptibility to Kawasaki's disease (KD).
|
21987091 |
2013 |
rs28493229
|
|
|
0.890 |
GeneticVariation |
BEFREE |
The meta-analyses first revealed significant risk for CALs in KD patients carrying risk allele of rs11340705, and the association of rs28493229 with KD was not observed in the Han Chinese.
|
23456091 |
2013 |
rs28493229
|
|
|
0.890 |
GeneticVariation |
BEFREE |
The inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) gene rs28493229 was recently found to be associated with the risk for KD in the Japanese population, suggesting that the ITPKC gene may contribute to KD susceptibility.
|
22361738 |
2012 |
rs28493229
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Recently, a single nucleotide polymorphism (SNP) of the inositol 1,4,5-triphosphate kinase C (ITPKC), rs28493229, was found to passively confer susceptibility for Kawasaki syndrome (KS) and subsequent coronary arterial lesions.
|
22498790 |
2012 |
rs28493229
|
|
|
0.890 |
GeneticVariation |
BEFREE |
This meta-analysis reveals that the functional polymorphism rs28493229 in ITPKC significantly contributes to the risk of KD.
|
23065250 |
2012 |
rs28493229
|
|
|
0.890 |
GeneticVariation |
BEFREE |
in a cohort from a population with the world's third highest incidence of KD, we demonstrated that the C-allele of ITPKC SNP rs28493229 is associated with KD susceptibility and BCG scar reactivation during the acute phase, although its frequency is lower than that in the Japanese cohort (22.6%), suggesting this SNP contributes to KD susceptibility through induced hyperimmune function reflected in the BCG reactivation.
|
20805785 |
2011 |
rs28493229
|
|
|
0.890 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.
|
22081228 |
2011 |
rs28493229
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Taken together, our results indicated that C-allele of ITPKC SNP rs284</span>93229 is associated with the susceptibility and aneurysm formation in KD patients in a Taiwanese population.
|
21533171 |
2011 |
rs28493229
|
|
|
0.890 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.
|
22081228 |
2011 |
rs28493229
|
|
|
0.890 |
GeneticVariation |
BEFREE |
In conclusion, we did not find a statistically significant association between the ITPKC gene SNP rs28493229 and KD or CALs in Taiwanese children.
|
20045869 |
2010 |
rs1801274
|
|
|
0.880 |
GeneticVariation |
BEFREE |
We performed a genetic association analysis in several KD subgroups categorized by clinical characteristics using the KD-associated variants of the B lymphoid tyrosine kinase (<i>BLK</i>; rs6993775) and Fc gamma receptor II a (<i>FCGR2A</i>; rs1801274) in a large number of case (n=1,011) and control (n=4,533) samples.
|
30468029 |
2019 |
rs1801274
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Now, we show in 1,028 European KD patients that the <i>FCGR2C</i>-ORF haplotype, although nearly absent in Asians, was more strongly associated with susceptibility to KD than rs1801274 in Europeans.
|
30949161 |
2019 |
rs1801274
|
|
|
0.880 |
GeneticVariation |
BEFREE |
In a meta-analysis with 1,461 cases and 5,302 controls, a very strong association of KD with the nonsynonymous SNP rs1801274 (p.His167Arg, previously assigned as p.His131Arg) in FCGR2A was confirmed in males (OR = 1.48, P = 1.43 × 10-7), but not in the females (OR = 1.17, P = 0.055).
|
28886140 |
2017 |
rs1801274
|
|
A |
0.880 |
GeneticVariation |
GWASCAT |
The present study demonstrates that p.His167Arg, a KD-associated FCGR2A variant, acts as a susceptibility gene in males only.
|
28886140 |
2017 |
rs1801274
|
|
|
0.880 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrates that the FCGR2A rs1801274 G-allele confers susceptibility to KD and UC.
|
27270653 |
2016 |
rs1801274
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Compared with their respective wild type counterparts, rs1801274 AG+GG genotypes and rs3818298 TC+CC genotypes were nominally associated with the reduced risk of KD (OR = 0.77, 95% CI = 0.59-0.99, P = 0.045; OR = 0.74, 95% CI = 0.56-0.98, P = 0.038).
|
25645453 |
2015 |
rs1801274
|
|
|
0.880 |
GeneticVariation |
BEFREE |
These results further confirm that rs1801274 in the FCGR2A gene is significantly associated with increased risk of KD.
|
25093412 |
2014 |
rs1801274
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Significant susceptibility to CALs was found in KD patients with high-risk genotypes at both rs1801274 and rs2857151.
|
23456091 |
2013 |
rs1801274
|
|
|
0.880 |
GeneticVariation |
BEFREE |
We also replicated the association of a functional SNP of FCGR2A (rs1801274, P = 1.6 × 10(-6)) identified in a recently reported GWAS of Kawasaki disease.
|
22446962 |
2012 |
rs1801274
|
|
A |
0.880 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.
|
22081228 |
2011 |
rs1801274
|
|
A |
0.880 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.
|
22081228 |
2011 |
rs2736340
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Stratification analysis by diseases suggested FAM167A-BLK rs2736340 had a positive association with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and Kawasaki disease, primary Sjogren's syndrome (pSS), primary antiphosholipid syndrome (APS), and myositis.
|
27105348 |
2016 |
rs2254546
|
|
|
0.820 |
GeneticVariation |
BEFREE |
In conclusion, rs2254546 polymorphism might significantly contribute to the risk of KD.
|
24577620 |
2014 |
rs2254546
|
|
|
0.820 |
GeneticVariation |
BEFREE |
As a result, the risk alleles of rs1801274 and rs2254546 were observed significant effect on KD with higher frequencies in 358 patients than those in 815 controls.
|
23456091 |
2013 |