Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1800693
rs1800693
TNFRSF1A
0.880 GeneticVariation BEFREE Genetic polymorphism (rs1800693) of TNFRSF1A (type 1 tumour necrosis factor receptor) encodes a potentially anti-inflammatory soluble truncated form of the p55 receptor, which is associated with predisposition to multiple sclerosis but protection against ankylosing spondylitis (AS). 29535371

2019
dbSNP: rs1800693
rs1800693
TNFRSF1A
0.880 GeneticVariation BEFREE In conclusion, our results provide support for a sex- and HLA-DRB1*15:01-independent association of TNFRSF1A rs1800</span>693 SNP with MS susceptibility, but not with age at disease onset, severity or rate of disability accumulation. 30009568

2018
dbSNP: rs1800693
rs1800693
TNFRSF1A
0.880 GeneticVariation BEFREE The MS disease aetiology is unknown, though a polymorphism of the TNFRSF1A gene, rs1800693, is known to confer an increased risk for MS. 29034884

2017
dbSNP: rs1800693
rs1800693
TNFRSF1A
C 0.880 GeneticVariation GWASCAT Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation. 27386562

2016
dbSNP: rs1800693
rs1800693
TNFRSF1A
0.880 GeneticVariation BEFREE The TNF-α inverse association with relapse was only present among persons carrying the wild-type of the functional SNP rs1800693 in TNFRSF1A that has been previously associated with MS risk. 24790215

2015
dbSNP: rs1800693
rs1800693
TNFRSF1A
0.880 GeneticVariation BEFREE The MS rs1800693(G) susceptibility allele affects the magnitude of monocyte responses to TNF-α stimulation, and the TNF pathway may be one network in which the effect of multiple MS genes becomes integrated. 24174586

2013
dbSNP: rs1800693
rs1800693
TNFRSF1A
G 0.880 GeneticVariation GWASCAT Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. 24076602

2013
dbSNP: rs1800693
rs1800693
TNFRSF1A
0.880 GeneticVariation BEFREE TNFRSF1A polymorphisms rs1800693 and rs4149584 in patients with multiple sclerosis. 23624563

2013
dbSNP: rs1800693
rs1800693
TNFRSF1A
0.880 GeneticVariation BEFREE This indicates that the clinical experience with these drugs parallels the disease association of rs1800693, and that the MS-associated TNFR1 variant mimics the effect of TNF-blocking drugs. 22801493

2012
dbSNP: rs1800693
rs1800693
TNFRSF1A
G 0.880 GeneticVariation GWASDB Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. 21833088

2011
dbSNP: rs1800693
rs1800693
TNFRSF1A
G 0.880 GeneticVariation GWASCAT Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. 21833088

2011
dbSNP: rs1800693
rs1800693
TNFRSF1A
0.880 GeneticVariation BEFREE In the recently published meta-analysis of multiple sclerosis genome-wide association studies De Jager et al. identified three single nucleotide polymorphisms associated to MS: rs17824933 (CD6), rs1800693 (TNFRSF1A) and rs17445836 (61.5 kb from IRF8). 21552549

2011
dbSNP: rs1800693
rs1800693
TNFRSF1A
C 0.880 GeneticVariation GWASDB Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. 19525953

2009
dbSNP: rs1800693
rs1800693
TNFRSF1A
C 0.880 GeneticVariation GWASCAT Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. 19525953

2009