Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2104286
rs2104286
0.900 GeneticVariation BEFREE We observed that MS-associated <i>IL2RA</i> SNPs rs2104286 and rs11256593 are associated with expression of CD25 in CD4<sup>+</sup> but not CD8<sup>+</sup> T cells. 31242590

2019

dbSNP: rs2104286
rs2104286
0.900 GeneticVariation BEFREE The gene polymorphisms at the loci of IL2RA rs2104286 and rs12722489 are closely associated with susceptibility to MS in the Han and Hui nationalities. 30352019

2018

dbSNP: rs2104286
rs2104286
0.900 GeneticVariation BEFREE Our meta-analysis suggests that the rs2104286 A allele is associated with increased MS risk in both Caucasians and Asians, whereas the rs12722489 C allele is associated with elevated MS risk in Caucasians but not in Asians. 29648897

2018

dbSNP: rs2104286
rs2104286
0.900 GeneticVariation BEFREE Correlations were strongest in HCs suggesting that immunological alterations may obscure the role of the IL2RA SNP rs2104286 in established MS. 28511943

2017

dbSNP: rs2104286
rs2104286
0.900 GeneticVariation BEFREE Although not statistically significant, the effect of IL2RA (rs2104286) in patients without a family history of MS indicates that the genetic components for familial and sporadic disease are perhaps distinct. 24770783

2014

dbSNP: rs2104286
rs2104286
A 0.900 GeneticVariation GWASCAT Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. 24076602

2013

dbSNP: rs2104286
rs2104286
0.900 GeneticVariation BEFREE IL2RA gene polymorphism rs2104286 A>G seen in multiple sclerosis is associated with intermediate uveitis: possible parallel pathways? 21911588

2011

dbSNP: rs2104286
rs2104286
0.900 GeneticVariation BEFREE Genome-wide association studies have identified an association between two intronic single nucleotide polymorphisms (SNPs), rs12722489 and rs2104286, in the interleukin-2 receptor alpha-chain gene (IL2RA) and susceptibility to multiple sclerosis (MS). 21239413

2011

dbSNP: rs2104286
rs2104286
0.900 GeneticVariation GWASDB Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. 22190364

2011

dbSNP: rs2104286
rs2104286
0.900 GeneticVariation BEFREE It was concluded that both of the IL2RA gene polymorphisms, rs2104286 and rs12722489, were associated with increased susceptibility to MS. 22117963

2011

dbSNP: rs2104286
rs2104286
0.900 GeneticVariation BEFREE Here, we show that the IL2RA genotypes differentially affects soluble IL-2RA (sIL-2RA) levels in MS cases vs healthy controls; the two variants associated with MS (rs12722489 and rs2104286) account for 15 and 18% of the total variance in log(10)-transformed sIL-2RA concentration in control subjects but less so in subjects with MS (2 and 5%), suggesting that perturbations associated with disease or treatment may influence sIL-2RA levels in subjects with MS. 19155502

2009

dbSNP: rs2104286
rs2104286
T 0.900 GeneticVariation GWASDB Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. 19525953

2009

dbSNP: rs2104286
rs2104286
T 0.900 GeneticVariation GWASCAT Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. 19525953

2009

dbSNP: rs2104286
rs2104286
0.900 GeneticVariation BEFREE We replicated the association of only one (rs2104286) of the two IL2RA SNPs identified in the recently performed genome-wide association study of MS. 19125193

2009

dbSNP: rs2104286
rs2104286
0.900 GeneticVariation GWASDB Risk alleles for multiple sclerosis identified by a genomewide study. 17660530

2007