|
rs4149584
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The SMR for R92Q in our pediatric MS population was 4.6 (95% CI 1.7-10.0), 7.0 (95% CI 2.6-15.2), and 13.6 (95% CI 5.0-29.7), depending on reference population.
|
28927886 |
2018 |
|
rs4149584
|
|
|
0.100 |
GeneticVariation |
BEFREE |
On the other hand, no association could be found between rs4149584 and MS risk (GA + AA vs. GG: pcorr = 1.00; OR = 1.25; 95% CI = 0.71-2.21).
|
30009568 |
2018 |
|
rs4149584
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Serum levels of sTNF-R1 and mRNA expression levels of the full-length receptor were significantly increased in patients with MS carrying the R92Q mutation (p = 0.003 and p = 0.011, respectively), but similarly distributed among rs1800693 genotypes; cell surface TNF-R1 expression in T cells did not differ between rs4149584 and rs1800693 genotypes.
|
23624563 |
2013 |
|
rs4149584
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Using archival serum samples and freshly isolated monocytes from patients with MS and healthy subjects, we evaluated the effects of rs1800693(G) and a second risk allele, R92Q, on immune function.
|
24174586 |
2013 |
|
rs4149584
|
|
|
0.100 |
GeneticVariation |
BEFREE |
R92Q mutation was more frequent in MS patients as compared to controls.
|
21567205 |
2012 |
|
rs4149584
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Patients with the autoinflammatory disease Tumour Necrosis Factor receptor-associated periodic syndrome (TRAPS) who suffer from demyelinating disease have been described, and one of the milder TRAPS mutations (R92Q in the TNFRSF1A gene) has been suggested as a risk factor for multiple sclerosis (MS).
|
21565411 |
2011 |
|
rs4149584
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The TNFRSF1A R92Q mutation behaves as a genetic risk factor for MS and other inflammatory diseases, including TRAPS.
|
22059991 |
2011 |
|
rs4149584
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Concurrent TNFRSF1A R92Q and pyrin E230K mutations in a child with multiple sclerosis.
|
20876156 |
2010 |
|
rs4149584
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A genome-wide association study has identified the R92Q variant of the TNFRSF1A gene as a new susceptibility locus for multiple sclerosis.
|
19794511 |
2009 |
|
rs4149584
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Twenty TNFRSF1A R92Q carriers had MS according to the McDonald criteria, and 1 had clinically isolated syndrome.
|
19029521 |
2008 |
|
rs4149584
|
|
|
0.100 |
GeneticVariation |
BEFREE |
All R92Q heterozygotes had similar symptoms, including arthralgias/arthritis, myalgias, urticarial rash, and severe fatigue, which began before the onset of MS.
|
17665448 |
2007 |