Gene: CLEC16A ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7200786
rs7200786
CLEC16A
A 0.800 GeneticVariation GWASDB Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. 21833088

2011
dbSNP: rs7200786
rs7200786
CLEC16A
A 0.800 GeneticVariation GWASCAT Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. 21833088

2011
dbSNP: rs11865121
rs11865121
CLEC16A
C 0.800 GeneticVariation GWASCAT Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. 19525953

2009
dbSNP: rs11865121
rs11865121
CLEC16A
C 0.800 GeneticVariation GWASDB Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. 19525953

2009
dbSNP: rs12708716
rs12708716
CLEC16A
0.710 GeneticVariation GWASDB Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. 21833088

2011
dbSNP: rs12708716
rs12708716
CLEC16A
0.710 GeneticVariation BEFREE In combined analyses, SNP rs12708716 gave the strongest association signal in MS (P=5.3 x 10⁻⁸, odds ratio 1.18, 95% confidence interval=1.11-1.25), and was found to be superior to the other SNP associations in conditional logistic regression analyses. 21179112

2011
dbSNP: rs6498160
rs6498160
CLEC16A
T 0.700 GeneticVariation GWASCAT Overexpression of the Cytokine BAFF and Autoimmunity Risk. 28445677

2017
dbSNP: rs6498168
rs6498168
CLEC16A
T 0.700 GeneticVariation GWASCAT Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation. 27386562

2016
dbSNP: rs12927355
rs12927355
CLEC16A
G 0.700 GeneticVariation GWASCAT Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. 24076602

2013
dbSNP: rs11860603
rs11860603
CLEC16A
0.700 GeneticVariation GWASDB Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. 19525953

2009
dbSNP: rs7184083
rs7184083
CLEC16A ; LOC105371081
0.700 GeneticVariation GWASDB Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. 19525953

2009
dbSNP: rs6498169
rs6498169
CLEC16A
0.030 GeneticVariation BEFREE Association of SNPs rs6498169 and rs10984447 with multiple sclerosis in Saudi patients: a model of the usefulness of familial aggregates in identifying genetic linkage in a multifactorial disease. 22492128

2012
dbSNP: rs6498169
rs6498169
CLEC16A
0.030 GeneticVariation BEFREE The described association of rs6498169 with MS was replicated in MS and RA cohorts. 19221398

2010
dbSNP: rs6498169
rs6498169
CLEC16A
0.030 GeneticVariation BEFREE Independent genome-wide association studies highlighted the function of CLEC16A/KIAA0350 polymorphisms modifying the risk to either multiple sclerosis (rs6498169) or type 1 diabetes (rs2903692). 19337309

2009
dbSNP: rs725613
rs725613
CLEC16A
0.020 GeneticVariation BEFREE We could replicate the finding for SNP rs725613 and were able to show for the first time the association of rs2041670, rs2080272 and rs998592 with MS. 20849399

2011
dbSNP: rs725613
rs725613
CLEC16A
0.020 GeneticVariation BEFREE In these Sardinian samples, allele A of rs725613 is positively associated not only with T1D (odds ratio=1.15, P one-tail=5.1 x 10(-3)) but also, and with a comparable effect size, with MS (odds ratio=1.21, P one-tail 6.7 x 10(-5)). 18946483

2009
dbSNP: rs8056098
rs8056098
CLEC16A
0.010 GeneticVariation BEFREE Three SNPs linked to MS clinical severity showed a significant association between the genotype and either the proportion of active lesions (rs2234978/FAS and rs11957313/KCNIP1) or the proportion of mixed active/inactive lesions (rs8056098/CLEC16A). 31228212

2020
dbSNP: rs2041670
rs2041670
CLEC16A
0.010 GeneticVariation BEFREE We could replicate the finding for SNP rs725613 and were able to show for the first time the association of rs2041670, rs2080272 and rs998592 with MS. 20849399

2011
dbSNP: rs2080272
rs2080272
CLEC16A
0.010 GeneticVariation BEFREE We could replicate the finding for SNP rs725613 and were able to show for the first time the association of rs2041670, rs2080272 and rs998592 with MS. 20849399

2011
dbSNP: rs998592
rs998592
CLEC16A
0.010 GeneticVariation BEFREE We could replicate the finding for SNP rs725613 and were able to show for the first time the association of rs2041670, rs2080272 and rs998592 with MS. 20849399

2011
dbSNP: rs1465201414
rs1465201414
CLEC16A
0.010 GeneticVariation BEFREE Rs4774 (missense +1614G/C; G500A) was associated with MS (P = 4.9 x 10(-3)), particularly in DRB1*1501 +individuals (P = 1 x 10(-4)). 20211854

2010
dbSNP: rs2903692
rs2903692
CLEC16A
0.010 GeneticVariation BEFREE Independent genome-wide association studies highlighted the function of CLEC16A/KIAA0350 polymorphisms modifying the risk to either multiple sclerosis (rs6498169) or type 1 diabetes (rs2903692). 19337309

2009