Gene: HLA-DRA ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3135388
rs3135388
HLA-DRA
0.890 GeneticVariation BEFREE DNA was extracted from blood in order to analyse EBV and HHV-6 viral load by quantitative real-time polymerase chain reaction and to genotype MS-related single nucleotide polymorphisms (rs3135388, rs2248359 and rs12368653) when possible. 29996002

2018
dbSNP: rs3135388
rs3135388
HLA-DRA
0.890 GeneticVariation BEFREE Presence of the rs3135388 polymorphism tagging the major MS risk allele HLA-DRB1*15:01 allele was determined as well. 28130760

2017
dbSNP: rs3135388
rs3135388
HLA-DRA
0.890 GeneticVariation BEFREE We genotyped a cohort of 1033 MS patients and 644 healthy controls with a consistent genetic background for the 57 non-MHC variants reported to be associated with MS by the first large GWAS as well as the HLA DRB1*1501 tagging SNP rs3135388. 26011527

2015
dbSNP: rs3135388
rs3135388
HLA-DRA
0.890 GeneticVariation BEFREE Our findings show for the first time that the rs3135388</span> polymorphism is a strong risk factor for MS in the Slovak population. 25958306

2015
dbSNP: rs3135388
rs3135388
HLA-DRA
A 0.890 GeneticVariation GWASCAT Genetic variants are major determinants of CSF antibody levels in multiple sclerosis. 25616667

2015
dbSNP: rs3135388
rs3135388
HLA-DRA
0.890 GeneticVariation BEFREE Our results indicate that the distribution of the rs3135388 gene polymorphism is a risk factor for MS susceptibility in the Czech female population. 23186557

2013
dbSNP: rs3135388
rs3135388
HLA-DRA
0.890 GeneticVariation BEFREE We analyzed the allelic and genotype frequency of VDR rs2228570, rs731236, and HLADRB1*1501 (rs3135388) in 303 patients with MS and 310 healthy controls, using TaqMan Assays. 23840333

2013
dbSNP: rs3135388
rs3135388
HLA-DRA
0.890 GeneticVariation BEFREE We observed a trend for association of rs3135388 (HLA-DRB1*1501, p < 0.01), rs7090530 (IL2RA, p < 0.026) and rs1841770 (ZIC1, p < 0.017) with a younger age at MS onset and of rs12044852 (CD58, p < 0.035) with shorter time to reach EDSS6. 22411505

2012
dbSNP: rs3135388
rs3135388
HLA-DRA
0.890 GeneticVariation BEFREE In quantitative terms, the MS-risk AA genotype carriers of rs3135388 were associated with 15.7-, 5.2- and 8.3-fold higher expression of DQB1, DRB5 and DRB1, respectively, than the non-risk GG carriers. 22253788

2012
dbSNP: rs3135388
rs3135388
HLA-DRA
A 0.890 GeneticVariation GWASDB Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. 19525953

2009
dbSNP: rs3135388
rs3135388
HLA-DRA
A 0.890 GeneticVariation GWASCAT Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. 19525953

2009
dbSNP: rs3135388
rs3135388
HLA-DRA
0.890 GeneticVariation BEFREE The tag SNP for HLA-DRB1*1501, rs3135388, is significantly associated with multiple sclerosis susceptibility: cost-effective high-throughput detection by real-time PCR. 19433080

2009
dbSNP: rs3135388
rs3135388
HLA-DRA
A 0.890 GeneticVariation GWASCAT Risk alleles for multiple sclerosis identified by a genomewide study. 17660530

2007
dbSNP: rs3135388
rs3135388
HLA-DRA
A 0.890 GeneticVariation GWASDB Risk alleles for multiple sclerosis identified by a genomewide study. 17660530

2007
dbSNP: rs3129871
rs3129871
HLA-DRA
0.800 GeneticVariation GWASDB Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles. 23472185

2013
dbSNP: rs3129871
rs3129871
HLA-DRA
0.800 GeneticVariation GWASCAT Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles. 23472185

2013
dbSNP: rs3129871
rs3129871
HLA-DRA
0.800 GeneticVariation GWASDB Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis. 20598377

2010
dbSNP: rs2395182
rs2395182
HLA-DRA
0.700 GeneticVariation GWASDB Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis. 20598377

2010
dbSNP: rs3129882
rs3129882
HLA-DRA
0.700 GeneticVariation GWASDB Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis. 20598377

2010
dbSNP: rs3129872
rs3129872
HLA-DRA
0.700 GeneticVariation GWASDB Risk alleles for multiple sclerosis identified by a genomewide study. 17660530

2007
dbSNP: rs3129877
rs3129877
HLA-DRA
0.700 GeneticVariation GWASDB Risk alleles for multiple sclerosis identified by a genomewide study. 17660530

2007
dbSNP: rs3135392
rs3135392
HLA-DRA
0.700 GeneticVariation GWASDB Risk alleles for multiple sclerosis identified by a genomewide study. 17660530

2007
dbSNP: rs3177928
rs3177928
HLA-DRA
0.700 GeneticVariation GWASDB Risk alleles for multiple sclerosis identified by a genomewide study. 17660530

2007
dbSNP: rs7194
rs7194
HLA-DRA
0.700 GeneticVariation GWASDB Risk alleles for multiple sclerosis identified by a genomewide study. 17660530

2007
dbSNP: rs9268645
rs9268645
HLA-DRA
0.700 GeneticVariation GWASDB Risk alleles for multiple sclerosis identified by a genomewide study. 17660530

2007