|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
No significant association between the IL7RA C/T (rs6897932) and IL12B A1188C (rs3212227) gene polymorphisms and MS susceptibility was observed.
|
30069682 |
2018 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This study suggested that the IL7R C allele was associated with an increased risk of MS and larger-scale studies of populations are needed to explore the roles played by the IL7R T244I polymorphism during the pathogenesis of MS.
|
27188999 |
2016 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
It was demonstrated that the IL7R T244I polymorphism was associated with susceptibility to MS.
|
27456877 |
2016 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Moreover, we revealed for the first time that rs6897932 in IL7Ra gene is associated with the progression of MS, evaluated by MSSS scores.
|
25903732 |
2015 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The study suggested that among Chinese Han population in southeastern China, the variant of IL-7RA (rs6897932) was associated with NMO especially NMO-IgG positive patients while the variant of IL-7 (rs1520333) with MS patients.
|
26608987 |
2015 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The T-allele in the single nucleotide polymorphism rs6897932 in the gene encoding the IL-7 receptor α (IL7RA) is associated with reduced risk of autoimmune diseases including multiple sclerosis and also affects the course of HIV infection.
|
25421942 |
2015 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In addition, the significant association between PrMS and rs6897932 indicates that IL7R may not be disease-causing but a determinant of disease course.
|
24770783 |
2014 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In addition, whereas no association was found between the alternative splicing SNP, rs6897932, and MS, a significant link was found between the promoter SNP, rs11567685, and MS.
|
24166352 |
2014 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Former studies demonstrated the single nucleotide polymorphism (SNP) rs6897932 C/T in the IL-7 receptor (IL-7R) gene was associated with susceptibility to autoimmune diseases, including multiple sclerosis and type I diabetes.
|
24242875 |
2014 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A meta‑analysis on the association between rs6897932</span> and the risk of MS was also performed.
|
24337176 |
2014 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The IL-7Rα single nucleotide polymorphism rs6897932 is associated with an increased risk for multiple sclerosis (MS).
|
22262655 |
2012 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The levels of sIL-7Rα increased dose-dependent upon rs6897932 [C] risk allele carriership in both HCs and MS. Next, we hypothesized that lower sIL-7Rα could result in a higher mIL-7Rα to soluble IL-7Rα ratio.
|
22914435 |
2012 |
|
rs6897932
|
|
G |
0.900 |
GeneticVariation |
GWASDB |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This revealed an association between IL7R T244I and MS (P < 0.00001 for the C-allele and the C/C genotype; P = 0.0004 for the C/C + C/T genotype), no heterogeneity was observed (allele C: P = 0.07; genotype C/C: P = 0.10).
|
21161391 |
2011 |
|
rs6897932
|
|
G |
0.900 |
GeneticVariation |
GWASCAT |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Homozygosity for the IL7R exon 6 rs6897932 C allele is associated with a higher risk for MS in our Dutch population.
|
21543551 |
2011 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
For MS, one of the first discoveries to emerge in this new era was the association with rs6897932[T244I] in the interleukin-7 receptor alpha chain (IL7RA) gene (Gregory et al. in Nat Genet 39(9):1083-1091, 2007; International Multiple Sclerosis Genetics Consortium in N Engl J Med 357(9):851-862, 2007; Lundmark in Nat Genet 39(9):1108-1113, 2007), a discovery that was accompanied by functional data that suggest this variant is likely to be causative rather than a surrogate proxy (Gregory et al. in Nat Genet 39(9):1083-1091, 2007).
|
20112030 |
2010 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Interleukin 7 receptor alpha polymorphism rs6897932 and susceptibility to multiple sclerosis in the Western Balkans.
|
20194581 |
2010 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We replicated the association of exon 6 variation (rs6897932) in IL7RA with MS.
|
19231135 |
2009 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The C allele of a single nucleotide polymorphism (SNP), rs6897932, located in the interleukin-7 receptor alpha chain (IL7RA) was recently found to be associated with multiple sclerosis and Type I diabetes.
|
19744146 |
2009 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These findings in our sample support previous reported association studies between IL7RA rs6897932 and MS.
|
18721276 |
2008 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
It is estimated that the C allele of a single nucleotide polymorphism, rs6897932, within the alternative spliced exon 6 of IL7RA is involved in about 30% of MS cases.
|
18461312 |
2008 |
|
rs6897932
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Risk alleles for multiple sclerosis identified by a genomewide study.
|
17660530 |
2007 |
|
rs6897932
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Risk alleles for multiple sclerosis identified by a genomewide study.
|
17660530 |
2007 |
|
rs6881706
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
|
24076602 |
2013 |