| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
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0.810 | GeneticVariation | BEFREE | Using flow cytometry we measured surface expression of CD40 and CD86 in B cells from 68 patients and 162 healthy controls that were genotyped for the multiple sclerosis associated single nucleotide polymorphisms (SNPs) rs4810485, which maps within the CD40 gene, and rs9282641, which maps within the CD86 gene. | 29361022 | 2018 |
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A | 0.810 | GeneticVariation | GWASCAT | Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. | 24076602 | 2013 |
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0.810 | GeneticVariation | GWASDB | Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. | 22190364 | 2011 |
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|
0.040 | GeneticVariation | BEFREE | We investigated the cell specific gene and protein expression variation controlled by the CD40 genetic variant(s) associated with MS, i.e. the T-allele at rs1883832. | 26068105 | 2015 |
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|
0.040 | GeneticVariation | BEFREE | Our investigation revealed that CT individuals in rs1883832 locus of CD40 possessed almost 1.5-fold higher risk for MS than CC individuals (OR = 1.44; 95%CI = 1.03-2.1; p = 0.032), while this risk for TT individuals was almost 2.5-fold higher (OR = 2.36; 95%CI = 1.19-4.78; p = 0.014). | 24912008 | 2014 |
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0.040 | GeneticVariation | BEFREE | From our analysis, we can speculate that the association between rs1883832 and MS was induced by LD, whereas rs6074022 was a marker in stronger LD with the functional variant or was the functional variant itself. | 23613777 | 2013 |
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0.040 | GeneticVariation | BEFREE | The impact of CD40 rs1883832 on MS and CD risk points to a common signaling shared by these autoimmune conditions. | 20634952 | 2010 |
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0.040 | GeneticVariation | BEFREE | Genotyping of rs1883832C>T was performed in 1564 MS, 1102 CD and 969 ulcerative colitis (UC) Spanish patients and in 2948 ethnically matched controls by TaqMan chemistry. | 20634952 | 2010 |