|
rs2973644
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found rs2973644 was significantly associated with increased risk of myopia (odds ratio [OR]: 1.26; 95% confidence intervals [CI]: 1.06-1.49; P = 0.009). furthermore, rs339501 (OR: 1.73; 95% CI: 1.18-2.53; P = 0.005), rs2973644 (OR: 1.57; 95% CI: 1.13-2.19; P = 0.007), and rs79002828 (OR: 1.83; 95% CI: 1.20-2.77; P = 0.005) were significantly associated with increased risk of high myopia in young children.
|
31021460 |
2019 |
|
rs4373767
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk allele T of <i>ZC3H11B</i> SNP rs4373767 was significantly associated with high myopia (OR=1.39, p=0.007) and extreme myopia (OR=1.34, p=0.013) when compared with controls, whereas <i>ZFHX1B</i> rs13382811 (allele T, OR=1.33, p=0.018) and <i>SNTB1</i> rs7839488 (allele G, OR=1.71, p=8.44E-05) were significantly associated with extreme myopia only.
|
31300455 |
2019 |
|
rs747797174
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Myopia disease mouse models: a missense point mutation (S673G) and a protein-truncating mutation of the <i>Zfp644</i> mimic human disease phenotype.
|
30834109 |
2019 |
|
rs748448196
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Myopia disease mouse models: a missense point mutation (S673G) and a protein-truncating mutation of the <i>Zfp644</i> mimic human disease phenotype.
|
30834109 |
2019 |
|
rs7839488
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk allele T of <i>ZC3H11B</i> SNP rs4373767 was significantly associated with high myopia (OR=1.39, p=0.007) and extreme myopia (OR=1.34, p=0.013) when compared with controls, whereas <i>ZFHX1B</i> rs13382811 (allele T, OR=1.33, p=0.018) and <i>SNTB1</i> rs7839488 (allele G, OR=1.71, p=8.44E-05) were significantly associated with extreme myopia only.
|
31300455 |
2019 |
|
rs79002828
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found rs2973644 was significantly associated with increased risk of myopia (odds ratio [OR]: 1.26; 95% confidence intervals [CI]: 1.06-1.49; P = 0.009). furthermore, rs339501 (OR: 1.73; 95% CI: 1.18-2.53; P = 0.005), rs2973644 (OR: 1.57; 95% CI: 1.13-2.19; P = 0.007), and rs79002828 (OR: 1.83; 95% CI: 1.20-2.77; P = 0.005) were significantly associated with increased risk of high myopia in young children.
|
31021460 |
2019 |
|
rs11873439
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our two-stage genome-wide association study of myopic maculopathy identifies a susceptibility locus at rs11873439 in an intron of CCDC102B (P = 1.77 × 10<sup>-12</sup> and P<sub>corr</sub> = 1.61 × 10<sup>-10</sup>).
|
29725004 |
2018 |
|
rs200329677
|
|
|
0.010 |
GeneticVariation |
BEFREE |
WNT7B SNPs located in the same genomic region that includes rs9330813 have previously been associated with CCT in Latinos but with other ocular quantitative traits related to myopia (corneal curvature and axial length) in a Japanese population (rs10453441 and rs200329677).
|
29847655 |
2018 |
|
rs2071754
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of tagging SNPs rs2071754 and rs644242 with extreme myopia could not withstand multiple correction (rs2071754: OR=1.25, P value=0.031; rs644242: OR=1.33, P value=0.032).
|
29436400 |
2018 |
|
rs8027411
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Persons with combinations of genotypes rs634990 CC and rs8027411 GT have 2.7 times higher odds to have myopia.
|
29793445 |
2018 |
|
rs9330813
|
|
|
0.010 |
GeneticVariation |
BEFREE |
WNT7B SNPs located in the same genomic region that includes rs9330813 have previously been associated with CCT in Latinos but with other ocular quantitative traits related to myopia (corneal curvature and axial length) in a Japanese population (rs10453441 and rs200329677).
|
29847655 |
2018 |
|
rs6469937
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association between either of these two SNPs alone and myopia did not replicate significantly in the combined cohorts of European descent, providing only suggestive results (<i>p</i><sub>allelic</sub> = 0.0088 for rs13382811 and <i>p</i><sub>allelic</sub> = 0.0319 for rs6469937).
|
28848321 |
2017 |
|
rs11743810
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four tSNPs (rs11743810 in the EGR1 gene; rs2571575, rs9321170, and rs1889891 in the LAMA2 gene) were selected, according to the HapMap database (http://hapmap.ncbi.nlm.nih.gov), and were genotyped using the ligase detection reaction (LDR) approach for 167 Han Chinese nuclear families with extremely highly myopic offspring (<-10.0 diopters) and an independent group with 485 extremely highly myopic cases (<-10.0 diopters) and 499 controls.
|
26984843 |
2016 |
|
rs1889891
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four tSNPs (rs11743810 in the EGR1 gene; rs2571575, rs9321170, and rs1889891 in the LAMA2 gene) were selected, according to the HapMap database (http://hapmap.ncbi.nlm.nih.gov), and were genotyped using the ligase detection reaction (LDR) approach for 167 Han Chinese nuclear families with extremely highly myopic offspring (<-10.0 diopters) and an independent group with 485 extremely highly myopic cases (<-10.0 diopters) and 499 controls.
|
26984843 |
2016 |
|
rs5742632
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A nonsignificant association of the IGF-1 gene rs5742632 polymorphism with the two myopia groups was also observed.
|
27167306 |
2016 |
|
rs669676
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that in the univariate analysis that both single-nucleotide polymorphisms in COL8A1 gene (rs13095226 and rs669676) together with age, sex and hypertension were significantly associated with myopic CNV development in Spanish patients (p<0.05).
|
27643879 |
2016 |
|
rs9321170
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four tSNPs (rs11743810 in the EGR1 gene; rs2571575, rs9321170, and rs1889891 in the LAMA2 gene) were selected, according to the HapMap database (http://hapmap.ncbi.nlm.nih.gov), and were genotyped using the ligase detection reaction (LDR) approach for 167 Han Chinese nuclear families with extremely highly myopic offspring (<-10.0 diopters) and an independent group with 485 extremely highly myopic cases (<-10.0 diopters) and 499 controls.
|
26984843 |
2016 |
|
rs1867315
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Before controlling for false discovery rate, the frequency of the rs1867315 C/C genotype compared with healthy controls was lower in the myopia group (p = 0.006) and in myopia patients without macular degeneration (p = 0.019).
|
23834555 |
2015 |
|
rs11218544
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study indicated that the 11q24.1 genomic region, and particularly the rs11218544 polymorphism, has a genetic association with the development of myopia.
|
24672220 |
2014 |
|
rs12716080
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the CTNND2 gene, neither rs6885224 nor rs12716080 was significantly associated with myopia {rs6885224: [OR and 95%CI: 1.051 (0.795-1.391), p=0.725], rs12716080: [OR and 95%CI: 1.173 (0.990-1.390), p=0.065]}.
|
24672220 |
2014 |
|
rs3026393
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five PAX6 SNPs, rs3026354, rs667773, rs2071754, rs644242, and rs3026393, were meta-analyzed in high myopia and two, rs667773 and rs644242, in extreme myopia.
|
24637479 |
2014 |
|
rs10462070
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three FGF10 SNPs in complete linkage disequilibrium--rs339501, rs12517396, and rs10462070--were associated with extreme myopia in the Japanese population, and the risk allele of rs339501 differed from the previous Chinese population.
|
24265547 |
2013 |
|
rs12517396
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three FGF10 SNPs in complete linkage disequilibrium--rs339501, rs12517396, and rs10462070--were associated with extreme myopia in the Japanese population, and the risk allele of rs339501 differed from the previous Chinese population.
|
24265547 |
2013 |
|
rs12603825
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We demonstrated a marginal association of the PEDF SNP, rs12603825, with myopic CNV in extremely myopic patients.
|
23722394 |
2013 |
|
rs10033900
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One SNP (rs10033900) in the CFI gene, which encodes a protein involved in the inflammatory pathway, was significantly associated with myopic CNV in multivariate analysis after correction for multiple testing.
|
22678500 |
2012 |